Pre_GI: BLASTN Hits

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Query: NC_008262:1721496 Clostridium perfringens SM101, complete genome

Start: 1721496, End: 1740213, Length: 18718

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_008262:90400090400092609922100Clostridium perfringens SM101, complete genome02401BLASTN svgBLASTP svg
NC_008262:784878*78487882991045033Clostridium perfringens SM101, complete genome02375BLASTN svgBLASTP svg
NC_010723:28738862873886289437620491Clostridium botulinum E3 str. Alaska E43, complete genome1e-66262BLASTN svgBLASTP svg
NC_010674:30495003049500307069321194Clostridium botulinum B str. Eklund 17B, complete genome3e-64254BLASTN svgBLASTP svg
NC_008262:20256992025699204408118383Clostridium perfringens SM101, complete genome1e-57232BLASTN svgBLASTP svg
NC_020291:50931385093138512061727480Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome8e-40172BLASTN svgBLASTP svg
NC_010516:34660003466000348809922100Clostridium botulinum B1 str. Okra, complete genome1e-38168BLASTN svgBLASTP svg
NC_020291:18105271810527182940518879Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome5e-38167BLASTN svgBLASTP svg
NC_004557:363628*36362838772724100Clostridium tetani E88, complete genome2e-22115BLASTN svgBLASTP svg
NC_020291:58088565808856585259243737Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome9e-1279.8BLASTN svgBLASTP svg
NC_012225:17752641775264179439519132Brachyspira hyodysenteriae WA1, complete genome1e-1075.8BLASTN svgBLASTP svg
NC_014614:35674635674640601049265Clostridium sticklandii, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_013171:312500*31250033387921380Anaerococcus prevotii DSM 20548, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_014330:1957725*1957725197782020096Brachyspira pilosicoli 95/1000 chromosome, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_012472:3625800*3625800364898123182Bacillus cereus 03BB102, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_008600:36110383611038362982518788Bacillus thuringiensis str. Al Hakam, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_007644:20998782099878212213022253Moorella thermoacetica ATCC 39073, complete genome1e-0765.9BLASTN svgBLASTP svg
NC_008593:555463*55546357939123929Clostridium novyi NT, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_014614:1259236*1259236127792218687Clostridium sticklandii, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_014150:26170722617072264049123420Brachyspira murdochii DSM 12563 chromosome, complete genome9e-0660BLASTN svgBLASTP svg