Pre_GI: BLASTP Hits

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Query: NC_008262:67711:84152 Clostridium perfringens SM101, complete genome

Start: 84152, End: 84952, Length: 801

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:2556457:256989825698982570698801Clostridium perfringens str. 13, complete genomehypothetical protein2e-153541
NC_020291:6216000:622888162288816229693813Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein2e-123441
NC_010723:3530000:356882235688223569640819Clostridium botulinum E3 str. Alaska E43, complete genomeprotein YqfL2e-108392
NC_010674:3674739:371179637117963712614819Clostridium botulinum B str. Eklund 17B, complete genomeprotein YqfL4e-107387
NC_004557:81362:813628136282177816Clostridium tetani E88, complete genomehypothetical protein9e-101366
NC_012658:3923546:394437939443793945188810Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein2e-99361
NC_012563:4101000:412184441218444122653810Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein7e-99360
NC_010516:3903867:392467739246773925486810Clostridium botulinum B1 str. Okra, complete genomehypothetical protein7e-99360
NC_010520:3938490:395931739593173960126810Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein7e-99360
NC_009495:3832500:385332438533243854133810Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein7e-99360
NC_009697:3809044:382985838298583830667810Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein7e-99360
NC_009698:3706154:372696837269683727777810Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein7e-99360
NC_009699:3940984:396180239618023962611810Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein7e-99360
NC_017297:3939328:395949739594973960306810Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein7e-99360
NC_014328:4546390:456506045650604565875816Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative ATP/GTP-binding protein7e-96350
NC_007907:3472494:348720534872053488026822Desulfitobacterium hafniense Y51, complete genomehypothetical protein2e-57222
NC_006270:2591317:261037726103772611189813Bacillus licheniformis ATCC 14580, complete genomehypothetical protein1e-55216
NC_006322:2592176:261123626112362612048813Bacillus licheniformis ATCC 14580, complete genomehypothetical protein1e-55216
NC_007644:626992:629855629855630739885Moorella thermoacetica ATCC 39073, complete genomeProtein of unknown function DUF2999e-55213
NC_013198:1538792:157170715717071572537831Lactobacillus rhamnosus GG, complete genomephosphotransferase1e-52206
NC_007168:454000:462645462645463475831Staphylococcus haemolyticus JCSC1435, complete genomehypothetical protein2e-45182
NC_013171:342714:380026380026380856831Anaerococcus prevotii DSM 20548, complete genomeprotein of unknown function DUF2991e-42173
NC_013939:492959:506775506775507626852Deferribacter desulfuricans SSM1, complete genomehypothetical protein6e-40164
NC_013943:2431643:243562124356212436430810Denitrovibrio acetiphilus DSM 12809 chromosome, complete genomehypothetical protein6e-39160
NC_008346:410940:412896412896413726831Syntrophomonas wolfei subsp. wolfei str. Goettingen, completehypothetical protein1e-36153
NC_012108:2194251:221125922112592212242984Desulfobacterium autotrophicum HRM2, complete genomehypothetical protein6e-32137
NC_007797:1016456:102355910235591024401843Anaplasma phagocytophilum HZ, complete genomehypothetical protein2e-31135
NC_006833:806467:825671825671826489819Wolbachia endosymbiont strain TRS of Brugia malayi, completehypothetical protein4e-30131
NC_007798:260324:266964266964267776813Neorickettsia sennetsu str. Miyayama, complete genomehypothetical protein2e-28125
NC_013009:270000:278157278157278969813Neorickettsia risticii str. Illinois, complete genomehypothetical protein9e-27120
NC_015381:2859000:292610529261052926920816Burkholderia gladioli BSR3 chromosome 1, complete sequencehypothetical protein8e-26117
NC_012560:2315350:232233423223342323152819Azotobacter vinelandii DJ, complete genomehypothetical protein6e-2097.8
NC_021150:2315362:232234623223462323164819Azotobacter vinelandii CA6, complete genomehypothetical protein6e-2097.8
NC_008228:2068641:208192420819242082736813Pseudoalteromonas atlantica T6c, complete genomeprotein of unknown function DUF2996e-1994.7
NC_011901:3072817:307281730728173073716900Thioalkalivibrio sulfidophilus HL-EbGr7 chromosome, completehypothetical protein7e-1994.4
NC_007482:607365:629179629179629988810Pseudoalteromonas haloplanktis TAC125 chromosome II, completehypothetical protein8e-1890.9
NC_012691:2050957:205956620595662060387822Tolumonas auensis DSM 9187, complete genomeprotein of unknown function DUF2991e-1790.5
NC_015850:2451957:245654424565442457386843Acidithiobacillus caldus SM-1 chromosome, complete genomehypothetical protein2e-1789.7