Pre_GI: BLASTP Hits

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Query: NC_008262:67711:72186 Clostridium perfringens SM101, complete genome

Start: 72186, End: 73361, Length: 1176

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:64908:6939969399705651167Clostridium perfringens str. 13, complete genomehypothetical protein0706
NC_008261:64678:6917069170703361167Clostridium perfringens ATCC 13124, complete genomemajor facilitator family transporter0706
NC_008593:2457594:2493438249343824946161179Clostridium novyi NT, complete genomeMajor Facilitator Superfamily protein2e-75283
NC_009495:38000:4596045960470931134Clostridium botulinum A str. ATCC 3502 chromosome, complete genomemajor facilitator superfamily protein3e-75282
NC_010516:42475:4607546075471841110Clostridium botulinum B1 str. Okra, complete genomemajor facilitator superfamily protein1e-74280
NC_012658:35500:3997439974410831110Clostridium botulinum Ba4 str. 657 chromosome, complete genomemajor facilitator superfamily protein2e-74280
NC_012563:36000:4039840398415071110Clostridium botulinum A2 str. Kyoto, complete genomemajor facilitator superfamily protein4e-74278
NC_009697:38000:4599945999471081110Clostridium botulinum A str. ATCC 19397 chromosome, completemajor facilitator superfamily protein4e-74278
NC_009698:38000:4599945999471081110Clostridium botulinum A str. Hall chromosome, complete genomemajor facilitator superfamily protein4e-74278
NC_009699:33452:4134141341424501110Clostridium botulinum F str. Langeland chromosome, complete genomemajor facilitator superfamily protein4e-74278
NC_017297:33519:4140941409425181110Clostridium botulinum F str. 230613 chromosome, complete genomemajor facilitator superfamily protein4e-74278
NC_010520:35845:4019040190412991110Clostridium botulinum A3 str. Loch Maree, complete genomemajor facilitator superfamily protein2e-73276
NC_015425:2690448:2727546272754627286491104Clostridium botulinum BKT015925 chromosome, complete genomemajor facilitator superfamily protein5e-73275
NC_021182:4058873:4058873405887340600871215Clostridium pasteurianum BC1, complete genomefucose permease1e-67257
NC_021182:4058873:4069005406900540701741170Clostridium pasteurianum BC1, complete genomefucose permease8e-56218
NC_010506:774455:7929327929327942091278Shewanella woodyi ATCC 51908, complete genomemajor facilitator superfamily MFS_11e-0964.3
NC_021066:5342127:5348290534829053494531164Raoultella ornithinolytica B6, complete genomeMFS-type transporter4e-0962.8
NC_011899:1437981:1441448144144814427251278Halothermothrix orenii H 168, complete genomemajor facilitator superfamily MFS_18e-0962
NC_010003:1242846:1258581125858112597201140Petrotoga mobilis SJ95, complete genomemajor facilitator superfamily MFS_19e-0858.2
NC_011837:238160:2399242399242411261203Clostridium kluyveri NBRC 12016, complete genomehypothetical protein1e-0757.8
NC_009706:238160:2399242399242410841161Clostridium kluyveri DSM 555 chromosome, complete genometransporter protein2e-0757.4
NC_015500:1204501:1216765121676512179251161Treponema brennaborense DSM 12168 chromosome, complete genomemajor facilitator superfamily MFS_12e-0757.4
NC_013440:1698047:1701854170185417030771224Haliangium ochraceum DSM 14365, complete genomemajor facilitator superfamily MFS_11e-0654.7
NC_010001:4520979:4537867453786745390541188Clostridium phytofermentans ISDg, complete genomemajor facilitator superfamily MFS_12e-0654.3
NC_015564:4727630:1109411094124101317Amycolicicoccus subflavus DQS3-9A1 chromosome, complete genomemajor facilitator superfamily transporter3e-0653.5
NC_016641:5671186:5699024569902457002201197Paenibacillus terrae HPL-003 chromosome, complete genomemajor facilitator superfamily protein4e-0653.1
NC_007604:1183497:1195317119531711964921176Synechococcus elongatus PCC 7942, complete genomehypothetical protein6e-0652.4
NC_010003:449192:4547234547234559071185Petrotoga mobilis SJ95, complete genomemajor facilitator superfamily MFS_16e-0652.4
NC_006576:414696:4243134243134254881176Synechococcus elongatus PCC 6301, complete genomehypothetical protein8e-0652
NC_013169:805124:8215848215848227801197Kytococcus sedentarius DSM 20547, complete genomearabinose efflux permease family protein9e-0651.6