Pre_GI: BLASTP Hits

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Query: NC_008262:654000:667786 Clostridium perfringens SM101, complete genome

Start: 667786, End: 668325, Length: 540

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008261:676000:689535689535690074540Clostridium perfringens ATCC 13124, complete genomehydrolase, NUDIX family1e-98358
NC_003366:728859:742291742291742764474Clostridium perfringens str. 13, complete genomehypothetical protein5e-84309
NC_021182:93000:107333107333107872540Clostridium pasteurianum BC1, complete genomeZn-finger containing NTP pyrophosphohydrolase3e-58224
NC_015425:2690448:273035727303572730866510Clostridium botulinum BKT015925 chromosome, complete genomeMutT/nudix family protein1e-57222
NC_008593:2457594:249607124960712496568498Clostridium novyi NT, complete genomeMutT/nudix family protein, putative1e-56219
NC_009495:38000:423844238442872489Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehydrolase, NUDIX family1e-49195
NC_009697:38000:423994239942887489Clostridium botulinum A str. ATCC 19397 chromosome, completeNUDIX family hydrolase1e-49195
NC_009698:38000:423994239942887489Clostridium botulinum A str. Hall chromosome, complete genomeNUDIX family hydrolase1e-49195
NC_010516:42475:424754247542963489Clostridium botulinum B1 str. Okra, complete genomehydrolase, NUDIX family6e-48189
NC_010520:35845:365933659337081489Clostridium botulinum A3 str. Loch Maree, complete genomehydrolase, NUDIX family6e-48189
NC_012563:36000:367983679837286489Clostridium botulinum A2 str. Kyoto, complete genomehydrolase, NUDIX family6e-48189
NC_009699:33452:377413774138229489Clostridium botulinum F str. Langeland chromosome, complete genomeNUDIX family hydrolase6e-48189
NC_017297:33519:378093780938297489Clostridium botulinum F str. 230613 chromosome, complete genomeNUDIX family hydrolase6e-48189
NC_012658:35500:363743637436862489Clostridium botulinum Ba4 str. 657 chromosome, complete genomeNUDIX family hydrolase2e-47187
NC_014833:3161257:317073831707383171259522Ruminococcus albus 7 chromosome, complete genomeNUDIX hydrolase2e-22105
NC_013740:15401:317913179132318528Acidaminococcus fermentans DSM 20731, complete genomeNUDIX hydrolase2e-1995.1
NC_016641:2225779:224222422422242242724501Paenibacillus terrae HPL-003 chromosome, complete genomeNTP pyrophosphohydrolase2e-1788.2
NC_004603:3080614:310703431070343107816783Vibrio parahaemolyticus RIMD 2210633 chromosome I, completeNADH pyrophosphatase6e-1786.7
NC_015565:2827444:283094928309492831737789Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completeNADH pyrophosphatase4e-1684.3
NC_007681:1007375:100825610082561009041786Methanosphaera stadtmanae DSM 3091, complete genomeNudC2e-1582
NC_009654:4253431:427188342718834272701819Marinomonas sp. MWYL1, complete genomeNAD(+) diphosphatase5e-1580.9
NC_014387:719245:738820738820739314495Butyrivibrio proteoclasticus B316 chromosome 1, complete genomeNUDIX domain-containing protein1e-1479.3
NC_014632:567289:572739572739573566828Ilyobacter polytropus DSM 2926 chromosome, complete genomeNAD(+) diphosphatase3e-1478.2
NC_007759:2179000:220455322045532205386834Syntrophus aciditrophicus SB, complete genomeNTP pyrophosphohydrolase containing a Zn-finger N4e-1270.9
NC_016629:3789554:383169938316993832574876Desulfovibrio africanus str. Walvis Bay chromosome, completeNAD(+) diphosphatase1e-1169.3
NC_015311:1612366:163950216395021640278777Prevotella denticola F0289 chromosome, complete genomeNUDIX family hydrolase3e-1168.2
NC_012984:2681548:269025426902542691078825Lactobacillus plantarum JDM1, complete genomepyrophosphatase (putative)3e-0961.2
NC_008618:1704462:1704462170446217055591098Bifidobacterium adolescentis ATCC 15703, complete genomehypothetical protein2e-0858.9
NC_012814:1599241:1601283160128316023921110Bifidobacterium animalis subsp. lactis Bl-04, complete genomehypothetical protein2e-0858.5
NC_014656:1161188:1161188116118811624801293Bifidobacterium longum subsp. longum BBMN68 chromosome, completenpy12e-0858.5
NC_017215:1605917:1605917160591716070261110Bifidobacterium animalis subsp. lactis CNCM I-2494 chromosome,NAD(+) diphosphatase2e-0858.5
NC_015067:459626:4871204871204884121293Bifidobacterium longum subsp. longum JCM 1217, complete genomehypothetical protein3e-0858.2
NC_004307:1108325:1108325110832511096171293Bifidobacterium longum NCC2705, complete genomehypothetical protein with N-terminal similarity to NADH pyrophosphatase3e-0858.2
NC_014169:515957:5343915343915356831293Bifidobacterium longum subsp. longum JDM301 chromosome, completeNUDIX hydrolase3e-0857.8
NC_011593:2288993:2290920229092022922121293Bifidobacterium longum subsp. infantis ATCC 15697 chromosome,NUDIX hydrolase4e-0857.8
NC_008702:4064470:406845240684524068979528Azoarcus sp. BH72, complete genomeconserved hypothetical protein9e-0856.6
NC_008781:3365468:336876133687613369294534Polaromonas naphthalenivorans CJ2, complete genomeNUDIX hydrolase2e-0652
NC_008212:2865737:288655428865542887075522Haloquadratum walsbyi DSM 16790, complete genomeADP-ribose pyrophosphatase4e-0651.2
NC_006347:5027580:504657650465765047100525Bacteroides fragilis YCH46, complete genomeputative mutT family protein1e-0549.7