Pre_GI: BLASTP Hits

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Query: NC_008262:381323:388411 Clostridium perfringens SM101, complete genome

Start: 388411, End: 389760, Length: 1350

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008261:381297:3859853859853873341350Clostridium perfringens ATCC 13124, complete genomeTldD/PmbA family protein0860
NC_010674:426256:4459544459544472971344Clostridium botulinum B str. Eklund 17B, complete genomeTldD/PmbA family protein1e-97357
NC_010723:420025:4407604407604421031344Clostridium botulinum E3 str. Alaska E43, complete genomeTldD/PmbA family protein5e-96352
NC_020291:552104:5682575682575696001344Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeTldD/PmbA family protein5e-96352
NC_016641:5808113:5809721580972158110641344Paenibacillus terrae HPL-003 chromosome, complete genomeZn-dependent protease9e-73274
NC_015707:826649:8468988468988482231326Thermotoga thermarum DSM 5069 chromosome, complete genomepeptidase U62 modulator of DNA gyrase1e-58227
NC_013642:505518:5244775244775257841308Thermotoga naphthophila RKU-10, complete genomepeptidase U62 modulator of DNA gyrase3e-58226
NC_010730:1519458:1530420153042015317481329Sulfurihydrogenibium sp. YO3AOP1, complete genomepeptidase U62 modulator of DNA gyrase3e-58226
NC_013894:543901:5456305456305469521323Thermocrinis albus DSM 14484 chromosome, complete genomepeptidase U62 modulator of DNA gyrase8e-53208
NC_011978:1812000:1813092181309218143961305Thermotoga neapolitana DSM 4359, complete genomePmbA-related protein2e-47190
NC_013410:3192836:3208124320812432094521329Fibrobacter succinogenes subsp. succinogenes S85 chromosome,peptidase U62 modulator of DNA gyrase2e-36153
NC_015216:2276929:2291858229185822931621305Methanobacterium sp. AL-21 chromosome, complete genomepeptidase U62 modulator of DNA gyrase1e-34147
NC_010003:1242846:1249401124940112507351335Petrotoga mobilis SJ95, complete genomepeptidase U62 modulator of DNA gyrase2e-34147
NC_014658:620819:6216416216416229331293Methanothermus fervidus DSM 2088 chromosome, complete genomepeptidase u62 modulator of DNA gyrase8e-34145
NC_003552:4054908:4054908405490840562271320Methanosarcina acetivorans C2A, complete genomePmbA/TldD family protein1e-33144
NC_013457:979102:9916979916979930401344Vibrio sp. Ex25 chromosome 2, complete genomepredicted Zn-dependent protease2e-31137
NC_006833:902744:9174909174909188241335Wolbachia endosymbiont strain TRS of Brugia malayi, completeInactivated homolog of predicted Zn-dependent protease, PmbA3e-31136
NC_017277:2746421:2759506275950627608461341Synechocystis sp. PCC 6803, complete genomehypothetical protein1e-30134
NC_017052:2745420:2758505275850527598451341Synechocystis sp. PCC 6803 substr. PCC-N, complete genomehypothetical protein1e-30134
NC_017039:2745432:2758517275851727598571341Synechocystis sp. PCC 6803 substr. PCC-P, complete genomehypothetical protein1e-30134
NC_000911:2747604:2760689276068927620291341Synechocystis sp. PCC 6803, complete genomehypothetical protein1e-30134
NC_014006:63000:8400884008853541347Sphingobium japonicum UT26S chromosome 1, complete genomeputative Zn-dependent protease PmbA2e-30134
NC_010003:1242846:1247989124798912494011413Petrotoga mobilis SJ95, complete genomepeptidase U62 modulator of DNA gyrase1e-29131
NC_013771:684966:7096017096017109411341Cyanobacterium UCYN-A, complete genomepredicted Zn-dependent protease-like protein1e-29130
NC_012559:1663214:1664482166448216655791098Laribacter hongkongensis HLHK9, complete genomePmbA6e-29129
NC_017517:867595:8880708880708894011332Neisseria meningitidis M01-240355 chromosome, complete genomeprotein PmbA2e-28127
NC_017515:1429317:1429317142931714306481332Neisseria meningitidis M04-240196 chromosome, complete genomeprotein PmbA2e-28127
NC_003112:844000:8650308650308663611332Neisseria meningitidis MC58, complete genomepmbA protein2e-28127
NC_017512:760000:7795607795607808911332Neisseria meningitidis WUE 2594, complete genomeputative PmbA-like protein2e-28127
NC_003116:988000:1008771100877110101021332Neisseria meningitidis Z2491, complete genomehypothetical protein2e-28127
NC_017505:841496:8620538620538633841332Neisseria meningitidis alpha710 chromosome, complete genomePmbA protein8e-28125
NC_010120:788000:8082748082748096051332Neisseria meningitidis 053442, complete genomepmbA protein7e-28125
NC_014540:2908912:2921753292175329231111359Burkholderia sp. CCGE1003 chromosome 2, complete sequencepeptidase U62 modulator of DNA gyrase7e-28125
NC_007354:569321:5878725878725892061335Ehrlichia canis str. Jake, complete genomePeptidase U62, modulator of DNA gyrase7e-28125
NC_006831:664000:6782586782586796251368Ehrlichia ruminantium str. Gardel, complete genomePmbA protein homolog1e-27124
NC_015942:2544407:2546427254642725478721446Acidithiobacillus ferrivorans SS3 chromosome, complete genomepeptidase U62 modulator of DNA gyrase7e-27122
NC_005295:689500:7027857027857041521368Ehrlichia ruminantium str. Welgevonden, complete genomeputative PmbA protein1e-26121
NC_006832:668913:6826316826316839981368Ehrlichia ruminantium str. Welgevonden, complete genomePmbA protein homolog1e-26121
NC_013407:1610221:1630496163049616317491254Methanocaldococcus vulcanius M7, complete genomepeptidase U62 modulator of DNA gyrase3e-26120
NC_008261:381297:3845843845843859691386Clostridium perfringens ATCC 13124, complete genomeTldD/PmbA family protein2e-26120
NC_007799:647514:6535166535166548621347Ehrlichia chaffeensis str. Arkansas, complete genomepmbA protein2e-26120
NC_006624:1952554:1951190195119019525571368Thermococcus kodakarensis KOD1, complete genomezinc-dependent protease, TldD/PmbA family7e-26118
NC_008262:381323:3870103870103883951386Clostridium perfringens SM101, complete genometldD protein truncated2e-25117
NC_016641:5808113:5811068581106858124621395Paenibacillus terrae HPL-003 chromosome, complete genomepeptidase u62 modulator of DNA gyrase2e-25117
NC_007513:1126914:1133461113346111348281368Synechococcus sp. CC9902, complete genomepossible modulator of DNA gyrase5e-25115
NC_011979:1683964:1705965170596517073471383Geobacter sp. FRC-32, complete genomepeptidase U62 modulator of DNA gyrase6e-25115
NC_016816:1545354:1549725154972515511821458Pantoea ananatis LMG 5342, complete genomeantibiotic maturation peptidase1e-24114
NC_016051:1385490:1405654140565414070151362Thermococcus sp. AM4 chromosome, complete genomeTldD/PmbA family zinc-dependent protease2e-24113
NC_009465:224564:2295482295482309751428Candidatus Vesicomyosocius okutanii HA, complete genomePmbA/TldD family DNA gyrase modulator3e-24113
NC_016816:1545354:1548358154835815497071350Pantoea ananatis LMG 5342, complete genomemicrocin-processing peptidase 15e-24112
NC_014122:842560:8550218550218562501230Methanocaldococcus infernus ME chromosome, complete genomepeptidase U62 modulator of DNA gyrase7e-24112
NC_014910:1200605:1203139120313912045601422Alicycliphilus denitrificans BC chromosome, complete genomepeptidase u62 modulator of DNA gyrase9e-24111
NC_011978:1812000:1814393181439318158081416Thermotoga neapolitana DSM 4359, complete genomeTldD protein1e-23111
NC_013642:505518:5230925230925244801389Thermotoga naphthophila RKU-10, complete genomepeptidase U62 modulator of DNA gyrase2e-23110
NC_009708:483253:5033115033115046511341Yersinia pseudotuberculosis IP 31758 chromosome, complete genomepeptidase PmbA3e-23109
NC_003413:1448377:1470356147035614716841329Pyrococcus furiosus DSM 3638, complete genomehypothetical protein4e-23109
NC_003143:4105754:4125645412564541269851341Yersinia pestis CO92, complete genomePutative modulator of DNA gyrase9e-23108
NC_009381:321577:3414693414693428091341Yersinia pestis Pestoides F chromosome, complete genomepeptidase PmbA9e-23108
NC_014029:4057696:4077587407758740789271341Yersinia pestis Z176003 chromosome, complete genomePutative modulator of DNA gyrase9e-23108
NC_017154:3997810:4017701401770140190411341Yersinia pestis D106004 chromosome, complete genomePutative modulator of DNA gyrase9e-23108
NC_017168:1729922:1749813174981317511531341Yersinia pestis A1122 chromosome, complete genomepeptidase PmbA9e-23108
NC_005070:1144777:1186170118617011875341365Synechococcus sp. WH 8102, complete genomepossible modulator of DNA gyrase6e-23108
NC_009655:866281:8695768695768709311356Actinobacillus succinogenes 130Z chromosome, complete genomepeptidase U62 modulator of DNA gyrase6e-23108
NC_015633:2919501:2937237293723729386821446Vibrio anguillarum 775 chromosome chromosome I, complete sequenceMicrocin-processing peptidase 26e-23108
NC_007973:2773427:2795043279504327964101368Ralstonia metallidurans CH34 chromosome 1, complete sequencepeptidase U62, modulator of DNA gyrase2e-22107
NC_005071:835005:8407428407428421301389Prochlorococcus marinus str. MIT 9313, complete genomepossible modulator of DNA gyrase2e-22107
NC_008312:1725763:1740339174033917417961458Trichodesmium erythraeum IMS101, complete genomepeptidase U62, modulator of DNA gyrase9e-22105
NC_015222:2136657:2160899216089921623741476Nitrosomonas sp. AL212 chromosome, complete genomepeptidase U62 modulator of DNA gyrase9e-22105
NC_003552:4054908:4056220405622040575751356Methanosarcina acetivorans C2A, complete genomePmbA/TldD family protein6e-22105
NC_013416:939668:9554379554379568851449Aggregatibacter actinomycetemcomitans D11S-1, complete genomeTldD6e-22105
NC_016051:1385490:1407021140702114083281308Thermococcus sp. AM4 chromosome, complete genomeTldD/PmbA family zinc-dependent protease2e-21103
NC_013209:2782500:2799102279910228005591458Acetobacter pasteurianus IFO 3283-01, complete genomeDNA gyrase modulator TldD7e-21102
NC_017100:2782303:2798894279889428003511458Acetobacter pasteurianus IFO 3283-03, complete genomeDNA gyrase modulator TldD7e-21102
NC_017108:2779303:2796231279623127976881458Acetobacter pasteurianus IFO 3283-12, complete genomeDNA gyrase modulator TldD7e-21102
NC_017111:2779321:2796249279624927977061458Acetobacter pasteurianus IFO 3283-32, complete genomeDNA gyrase modulator TldD7e-21102
NC_017121:2781000:2797651279765127991081458Acetobacter pasteurianus IFO 3283-07, complete genomeDNA gyrase modulator TldD7e-21102
NC_017125:2782283:2798874279887428003311458Acetobacter pasteurianus IFO 3283-22, complete genomeDNA gyrase modulator TldD7e-21102
NC_017146:2782325:2798916279891628003731458Acetobacter pasteurianus IFO 3283-26, complete genomeDNA gyrase modulator TldD7e-21102
NC_017150:2689920:2706848270684827083051458Acetobacter pasteurianus IFO 3283-01-42C, complete genomeDNA gyrase modulator TldD7e-21102
NC_006677:2042387:2044485204448520458161332Gluconobacter oxydans 621H, complete genomePmbA protein7e-21102
NC_000961:1366000:1387847138784713891841338Pyrococcus horikoshii OT3, complete genomehypothetical protein5e-21102
NC_010723:420025:4393744393744407561383Clostridium botulinum E3 str. Alaska E43, complete genomeTldD protein5e-21102
NC_004347:4211241:4231892423189242332351344Shewanella oneidensis MR-1, complete genomepmba protein3e-20100
NC_015707:826649:8455138455138469011389Thermotoga thermarum DSM 5069 chromosome, complete genomemicrocin-processing peptidase 22e-20100
NC_014540:2908912:2923270292327029247541485Burkholderia sp. CCGE1003 chromosome 2, complete sequencepeptidase U62 modulator of DNA gyrase4e-2099.8
NC_005955:427142:4405774405774419951419Bartonella quintana str. Toulouse, complete genometldD protein4e-2099.4
NC_014323:3195178:3210664321066432120371374Herbaspirillum seropedicae SmR1 chromosome, complete genomeZn-dependent protease TLDE protein5e-2099.4
NC_020291:552104:5668695668695682541386Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeprotein TldD5e-2099.4
NC_010674:426256:4445684445684459501383Clostridium botulinum B str. Eklund 17B, complete genomeTldD protein1e-1997.8
NC_005125:637333:6511216511216524251305Gloeobacter violaceus PCC 7421, complete genomehypothetical protein2e-1997.4
NC_000961:1366000:1386469138646913878451377Pyrococcus horikoshii OT3, complete genomehypothetical protein2e-1997.1
NC_008319:1167213:1182748118274811840941347Synechococcus sp. CC9311, complete genometldD/pmbA family protein3e-1996.7
NC_014323:3195178:3209126320912632106311506Herbaspirillum seropedicae SmR1 chromosome, complete genomeZn-dependent protease TldD protein3e-1996.7
NC_006624:1952554:1952554195255419538431290Thermococcus kodakarensis KOD1, complete genomezinc-dependent protease, TldD/PmbA family1e-1895.1
NC_012668:160357:1872221872221886671446Vibrio cholerae MJ-1236 chromosome 1, complete sequenceTldD protein probably a protease1e-1894.7
NC_007604:1145373:1145373114537311468421470Synechococcus elongatus PCC 7942, complete genomeputative modulator of DNA gyrase; TldD2e-1894
NC_006576:456569:4739624739624754311470Synechococcus elongatus PCC 6301, complete genomeputative modulator of DNA gyrase TldD2e-1894
NC_003413:1448377:1468976146897614703431368Pyrococcus furiosus DSM 3638, complete genomehypothetical TLDD protein6e-1892.4
NC_005877:864118:8785098785098798611353Picrophilus torridus DSM 9790, complete genomezinc metalloprotease8e-1892
NC_013457:979102:9930409930409944251386Vibrio sp. Ex25 chromosome 2, complete genomeputative TldD protein1e-1791.3
NC_013926:1166454:1183525118352511848261302Aciduliprofundum boonei T469 chromosome, complete genomepeptidase U62 modulator of DNA gyrase3e-1790.1
NC_008319:1167213:1184118118411811855631446Synechococcus sp. CC9311, complete genomeTldD protein4e-1789.7
NC_007513:1126914:1132046113204611334581413Synechococcus sp. CC9902, complete genomeputative modulator of DNA gyrase; TldD2e-1687.8
NC_012623:1563678:1572579157257915738081230Sulfolobus islandicus Y.N.15.51 chromosome, complete genomepeptidase U62 modulator of DNA gyrase2e-1584.3
NC_005071:835005:8392978392978407421446Prochlorococcus marinus str. MIT 9313, complete genomeputative modulator of DNA gyrase; TldD4e-1583.2
NC_002578:828000:8670538670538684201368Thermoplasma acidophilum DSM 1728, complete genomehypothetical protein5e-1582.8
NC_005070:1144777:1187537118753711889461410Synechococcus sp. WH 8102, complete genomeputative modulator of DNA gyrase; TldD2e-1377.8
NC_002578:828000:8684178684178697091293Thermoplasma acidophilum DSM 1728, complete genomehypothetical protein2e-1274.3
NC_005877:864118:8798138798138811261314Picrophilus torridus DSM 9790, complete genomePmbA protein6e-1272.4
NC_000854:50407:6254962549639971449Aeropyrum pernix K1, complete genomeprobable peptidase8e-1272
NC_015687:250768:2596462596462610731428Clostridium acetobutylicum DSM 1731 chromosome, complete genomeZn-dependent protease TldD1e-1171.6
NC_003030:249648:2596482596482610751428Clostridium acetobutylicum ATCC 824, complete genomePredicted Zn-dependent protease, TLDD ortholog1e-1171.6
NC_021182:93000:1342201342201356471428Clostridium pasteurianum BC1, complete genomeputative Zn-dependent protease-like protein3e-1170.1
NC_000854:50407:6401264012653611350Aeropyrum pernix K1, complete genomeprobable peptidase2e-1067.4
NC_013926:1166454:1184831118483111861951365Aciduliprofundum boonei T469 chromosome, complete genomepeptidase U62 modulator of DNA gyrase2e-0964.7
NC_015518:1638262:1643231164323116446041374Acidianus hospitalis W1 chromosome, complete genomepeptidase U62 modulator of DNA gyrase5e-0962.8
NC_012623:1563678:1571210157121015725861377Sulfolobus islandicus Y.N.15.51 chromosome, complete genomepeptidase U62 modulator of DNA gyrase1e-0861.6