Pre_GI: BLASTP Hits

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Query: NC_008262:297960:321257 Clostridium perfringens SM101, complete genome

Start: 321257, End: 322606, Length: 1350

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008261:304000:3265183265183278671350Clostridium perfringens ATCC 13124, complete genome[Fe] hydrogenase0850
NC_010516:3845942:3867259386725938686081350Clostridium botulinum B1 str. Okra, complete genome[Fe] hydrogenase1e-134479
NC_009698:3647955:3669220366922036705691350Clostridium botulinum A str. Hall chromosome, complete genome[Fe] hydrogenase3e-134478
NC_014328:2203437:2203437220343722047831347Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative Iron only hydrogenase large subunit1e-126453
NC_007907:960104:9669189669189681951278Desulfitobacterium hafniense Y51, complete genomehypothetical protein6e-89328
NC_020134:2832857:2836197283619728375851389Clostridium stercorarium subsp. stercorarium DSM 8532, completehydrogenase large subunit domain protein5e-78291
NC_015425:2389400:2403109240310924045931485Clostridium botulinum BKT015925 chromosome, complete genomeFe-hydrogenase large subunit family protein5e-55215
NC_008593:2136759:2146548214654821480321485Clostridium novyi NT, complete genomeFe-hydrogenase large subunit family protein2e-52206
NC_009495:3502000:3512133351213335136291497Clostridium botulinum A str. ATCC 3502 chromosome, complete genome[Fe] hydrogenase6e-51202
NC_009697:3463736:3488121348812134896141494Clostridium botulinum A str. ATCC 19397 chromosome, complete[Fe] hydrogenase5e-51202
NC_015958:1983815:2002191200219120037321542Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomehydrogenase large subunit domain-containing protein5e-51202
NC_017297:3594000:3604382360438236058751494Clostridium botulinum F str. 230613 chromosome, complete genome[Fe] hydrogenase6e-51201
NC_009699:3581376:3605767360576736072601494Clostridium botulinum F str. Langeland chromosome, complete genome[Fe] hydrogenase6e-51201
NC_004557:2552418:2556219255621925577031485Clostridium tetani E88, complete genomeperiplasmic [Fe] hydrogenase 19e-51201
NC_015389:1298689:1320798132079813223511554Coriobacterium glomerans PW2 chromosome, complete genomehydrogenase large subunit domain protein1e-50201
NC_010520:3580000:3589336358933635908291494Clostridium botulinum A3 str. Loch Maree, complete genome[Fe] hydrogenase4e-50199
NC_012563:3729817:3754207375420737557001494Clostridium botulinum A2 str. Kyoto, complete genome[Fe] hydrogenase4e-49196
NC_020291:491000:5095775095775110641488Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeferredoxin hydrogenase4e-48192
NC_009617:385000:3941173941173956071491Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeferredoxin hydrogenase3e-47189
NC_010674:370629:3876673876673891511485Clostridium botulinum B str. Eklund 17B, complete genomeiron-dependent hydrogenase5e-47189
NC_010723:371741:3830613830613845451485Clostridium botulinum E3 str. Alaska E43, complete genomeiron-dependent hydrogenase1e-46187
NC_014824:133065:1464801464801479161437Ruminococcus albus 7 plasmid pRUMAL01, complete sequencehydrogenase large subunit domain protein2e-44180
NC_013203:472679:4744474744474760421596Atopobium parvulum DSM 20469, complete genomeFerredoxin hydrogenase1e-43177
NC_014364:3500041:3519450351945035209641515Spirochaeta smaragdinae DSM 11293 chromosome, complete genomehydrogenase large subunit domain protein7e-43175
NC_006138:2683545:2717282271728227187331452Desulfotalea psychrophila LSv54, complete genomesimilar to hydrogenase3e-41170
NC_010001:109893:1200331200331214871455Clostridium phytofermentans ISDg, complete genomeFerredoxin hydrogenase2e-40167
NC_010424:448865:4541674541674556241458Candidatus Desulforudis audaxviator MP104C, complete genomehydrogenase large subunit domain protein9e-37154
NC_010644:485966:5097615097615111971437Elusimicrobium minutum Pei191, complete genomehydrogenase large subunit1e-34147
NC_010320:671699:6831316831316848731743Thermoanaerobacter sp. X514 chromosome, complete genomeputative PAS/PAC sensor protein1e-26121
NC_010321:244371:2530382530382547711734Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completehydrogenase1e-26121
NC_015958:1983815:1989439198943919911661728Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomeputative PAS/PAC sensor protein4e-26119
NC_014377:532816:5487185487185504181701Thermosediminibacter oceani DSM 16646 chromosome, complete genomeNAD(P)-dependent iron-only hydrogenase catalytic subunit3e-24113
NC_019978:7535:2927929279309671689Halobacteroides halobius DSM 5150, complete genomeiron only hydrogenase large subunit4e-22106
NC_014824:133065:1436251436251453011677Ruminococcus albus 7 plasmid pRUMAL01, complete sequenceputative PAS/PAC sensor protein1e-20100
NC_015519:2605709:2613464261346426154431980Tepidanaerobacter sp. Re1 chromosome, complete genomehydrogenase, Fe-only4e-2099.8
NC_020291:2701149:2703814270381427051871374Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome[FeFe] hydrogenase, group A5e-2099.4
NC_016012:879972:8821658821658839011737Candidatus Arthromitus sp. SFB-rat-Yit, complete genomeiron hydrogenase5e-2099.4
NC_010001:109893:1227551227551244881734Clostridium phytofermentans ISDg, complete genomeputative PAS/PAC sensor protein1e-1998.2
NC_013385:1758383:1778719177871917804701752Ammonifex degensii KC4, complete genomehydrogenase, Fe-only1e-1997.8
NC_012778:207415:2259602259602276421683Eubacterium eligens ATCC 27750, complete genomeNADH dehydrogenase I chain G3e-1996.7
NC_019978:2260395:2284480228448022862071728Halobacteroides halobius DSM 5150, complete genomehydrogenase, Fe-only6e-1995.9
NC_013385:1758383:1776695177669517784311737Ammonifex degensii KC4, complete genomehydrogenase, Fe-only7e-1995.5
NC_014328:773095:7859367859367873241389Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeFe-Fe hydrogenase 22e-1894.4
NC_008261:2920999:2926027292602729277451719Clostridium perfringens ATCC 13124, complete genomeiron hydrogenase6e-1892.4
NC_011830:2177187:2194046219404621974983453Desulfitobacterium hafniense DCB-2, complete genomehydrogenase, Fe-only2e-1790.5
NC_015578:1038588:1043196104319610449471752Treponema primitia ZAS-2 chromosome, complete genomeferredoxin 23e-1790.5
NC_011837:830436:8416928416928430921401Clostridium kluyveri NBRC 12016, complete genomehypothetical protein3e-1790.1
NC_009706:830461:8417448417448431171374Clostridium kluyveri DSM 555 chromosome, complete genomeFe-Fe hydrogenase 23e-1790.1
NC_015949:2327500:2327610232761023294811872Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomemethyl-accepting chemotaxis sensory transducer3e-1790.1
NC_016048:1602500:1603093160309316047871695Oscillibacter valericigenes Sjm18-20, complete genomeputative uptake hydrogenase subunit HupA3e-1790.1
NC_016627:1485799:1518304151830415200791776Clostridium clariflavum DSM 19732 chromosome, complete genomehydrogenase, Fe-only4e-1789.7
NC_015589:2555000:2555101255510125568131713Desulfotomaculum ruminis DSM 2154 chromosome, complete genomePAS fold domain-containing protein5e-1789.4
NC_010001:109893:1154371154371171401704Clostridium phytofermentans ISDg, complete genomehydrogenase, Fe-only6e-1789.4
NC_007503:1383255:1383255138325513854532199Carboxydothermus hydrogenoformans Z-2901, complete genomesigma-54 dependent transcriptional regulator1e-1688.6
NC_004663:107019:1132011132011149671767Bacteroides thetaiotaomicron VPI-5482, complete genomeNADH:ubiquinone oxidoreductase subunit1e-1584.3
NC_010334:1701957:1701957170195717031891233Shewanella halifaxensis HAW-EB4, complete genomehydrogenase, Fe-only2e-1584.3
NC_013315:3689422:3708153370815337095291377Clostridium difficile CD196 chromosome, complete genomehydrogenase4e-1582.8
NC_007519:64157:7582175821770861266Desulfovibrio alaskensis G20 chromosome, complete genomeferredoxin hydrogenase3e-1480.1
NC_013740:2141523:2158428215842821601581731Acidaminococcus fermentans DSM 20731, complete genomehydrogenase, Fe-only1e-1378.2
NC_016584:3826300:3826300382630038291252826Desulfosporosinus orientis DSM 765 chromosome, complete genomesignal transduction histidine kinase5e-1375.9
NC_014328:2203437:2216007221600722179231917Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative transcriptional regulator6e-1375.9
NC_015425:2072703:2098141209814121000301890Clostridium botulinum BKT015925 chromosome, complete genometranscriptional regulator4e-1273.2
NC_015577:3735558:3735558373555837376452088Treponema azotonutricium ZAS-9 chromosome, complete genome4Fe-4S binding domain-containing protein3e-1170.1
NC_016627:1485799:1512139151213915134731335Clostridium clariflavum DSM 19732 chromosome, complete genomeiron only hydrogenase large subunit4e-0963.2
NC_011661:938754:9431119431119444421332Dictyoglomus turgidum DSM 6724, complete genomeFe-S cluster domain protein4e-0756.6