Pre_GI: BLASTP Hits

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Query: NC_008262:297960:302918 Clostridium perfringens SM101, complete genome

Start: 302918, End: 303595, Length: 678

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:332500:335081335081335758678Clostridium perfringens str. 13, complete genomeuracil-DNA glycosylase1e-128458
NC_008261:304000:306730306730307407678Clostridium perfringens ATCC 13124, complete genomeuracil-DNA glycosylase2e-128457
NC_015634:2933712:294106829410682941754687Bacillus coagulans 2-6 chromosome, complete genomeuracil-DNA glycosylase7e-87319
NC_016023:1501553:151616715161671516853687Bacillus coagulans 36D1 chromosome, complete genomeuracil-DNA glycosylase3e-86318
NC_016894:3329562:333335633333563334054699Acetobacterium woodii DSM 1030 chromosome, complete genomeuracil-DNA glycosylase6e-77286
NC_014387:1528000:154689615468961547576681Butyrivibrio proteoclasticus B316 chromosome 1, complete genomeuracil-DNA glycosylase Ung13e-75281
NC_013766:417991:428301428301429011711Listeria monocytogenes 08-5578 chromosome, complete genomeuracil-DNA glycosylase6e-66250
NC_013768:418000:428322428322429032711Listeria monocytogenes 08-5923, complete genomeuracil-DNA glycosylase6e-66250
NC_003210:403743:414095414095414760666Listeria monocytogenes EGD-e, complete genomeuracil-DNA glycosylase8e-66249
NC_013891:353625:363558363558364220663Listeria seeligeri serovar 1/2b str. SLCC3954, complete genomeuracil-DNA glycosylase2e-65248
NC_013508:2870954:287126828712682871963696Edwardsiella tarda EIB202, complete genomeuracil-DNA glycosylase8e-65246
NC_012660:1579204:158275315827531583445693Pseudomonas fluorescens SBW25 chromosome, complete genomeuracil-DNA glycosylase3e-64244
CP002516:1196000:121749212174921218181690Escherichia coli KO11, complete genomeuracil-DNA glycosylase9e-64243
NC_021150:1322000:132616513261651326863699Azotobacter vinelandii CA6, complete genomeuracil-DNA glycosylase8e-64243
NC_012560:1322000:132615313261531326851699Azotobacter vinelandii DJ, complete genomeuracil-DNA glycosylase8e-64243
NC_012912:1200000:122044912204491221135687Dickeya zeae Ech1591, complete genomeuracil-DNA glycosylase6e-64243
NC_016818:3736213:373835337383533739033681Rahnella aquatilis CIP 78.65 = ATCC 33071 chromosome, completeuracil-DNA glycosylase4e-63240
NC_010102:283364:304340304340305029690Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein8e-63239
NC_010278:398521:407911407911408588678Actinobacillus pleuropneumoniae serovar 3 str. JL03 chromosome,uracil-DNA glycosylase3e-62238
NC_010939:405477:430793430793431470678Actinobacillus pleuropneumoniae serovar 7 str. AP76, completeuracil-DNA glycosylase3e-62238
NC_009053:393700:403081403081403758678Actinobacillus pleuropneumoniae L20, complete genomeuracil-DNA glycosylase3e-62238
NC_015061:3725921:372592137259213726601681Rahnella sp. Y9602 chromosome, complete genomeuracil-DNA glycosylase8e-62236
NC_012214:1117325:113717511371751137858684Erwinia pyrifoliae Ep1/96, complete genomeUracil-DNA-glycosylase2e-61235
NC_015224:3587500:358828535882853588971687Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,uracil-DNA glycosylase2e-61234
NC_008800:1090000:112267311226731123359687Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,uracil-DNA glycosylase3e-61234
NC_020064:3609844:361057636105763611259684Serratia marcescens FGI94, complete genomeUracil-DNA glycosylase4e-61234
NC_017027:1329708:132970813297081330376669Pasteurella multocida subsp. multocida str. HN06 chromosome,uracil-DNA glycosylase9e-59226
NC_008309:502983:521400521400522071672Haemophilus somnus 129PT, complete genomeuracil-DNA glycosylase (UDG)4e-58224
NC_010519:2033980:203398020339802034651672Haemophilus somnus 2336 chromosome, complete genomeuracil-DNA glycosylase4e-58224
NC_013410:3017983:303614630361463036823678Fibrobacter succinogenes subsp. succinogenes S85 chromosome,uracil-DNA glycosylase6e-58223
NC_007520:407627:410938410938411636699Thiomicrospira crunogena XCL-2, complete genomeuracil-DNA glycosylase6e-56217
NC_014752:1063506:108428010842801084939660Neisseria lactamica ST-640, complete genomelipoprotein7e-56216
NC_005061:594500:606597606597607262666Candidatus Blochmannia floridanus, complete genomeuracil-DNA glycosylase1e-55216
NC_014909:619407:619407619407620075669Candidatus Blochmannia vafer str. BVAF chromosome, complete genomeuracil-DNA glycosylase2e-55215
NC_011035:829945:834633834633835292660Neisseria gonorrhoeae NCCP11945 chromosome, complete genomeuracil-DNA glycosylase2e-55215
NC_018644:637497:658184658184658861678Alpha proteobacterium HIMB59 chromosome, complete genomeUracil-DNA glycosylase5e-55214
NC_015696:798000:809814809814810470657Francisella sp. TX077308 chromosome, complete genomeUracil-DNA glycosylase, family 14e-55214
NC_010120:1065833:108730810873081087967660Neisseria meningitidis 053442, complete genomeuracil-DNA glycosylase6e-55213
NC_010336:1282265:129662612966261297282657Francisella philomiragia subsp. philomiragia ATCC 25017, completeuracil-DNA glycosylase6e-54210
NC_008601:1560482:157643415764341577096663Francisella tularensis subsp. novicida U112, complete genomeuracil DNA glycosylase7e-54210
NC_010677:353839:356562356562357224663Francisella tularensis subsp. mediasiatica FSC147, complete genomeuracil-DNA glycosylase2e-53209
NC_008245:1625715:164167216416721642334663Francisella tularensis subsp. tularensis FSC 198, complete genomeUracil-DNA glycosylase2e-53209
NC_006570:1625909:164186616418661642528663Francisella tularensis subsp. tularensis Schu 4, complete genomeuracil-DNA glycosylase2e-53209
NC_009257:338994:341865341865342527663Francisella tularensis subsp. tularensis WY96-3418 chromosome,uracil-DNA glycosylase2e-53209
NC_016933:1702500:171761617176161718278663Francisella tularensis TIGB03 chromosome, complete genomeUracil-DNA glycosylase family 12e-53209
NC_016937:1625752:164170916417091642371663Francisella tularensis subsp. tularensis TI0902 chromosome,Uracil-DNA glycosylase family 12e-53209
NC_008369:514995:514995514995515657663Francisella tularensis subsp. holarctica OSU18, complete genomeuracil-DNA glycosylase1e-52206
NC_009749:510266:513136513136513798663Francisella tularensis subsp. holarctica FTA, complete genomeuracil-DNA glycosylase1e-52206
NC_007880:508407:511277511277511939663Francisella tularensis subsp. holarctica, complete genomeUracil-DNA glycosylase1e-52206
NC_015510:1234500:125429912542991254964666Haliscomenobacter hydrossis DSM 1100 chromosome, complete genomeUracil-DNA glycosylase5e-49194
NC_008609:206313:218706218706219341636Pelobacter propionicus DSM 2379, complete genomeuracil-DNA glycosylase9e-49193
NC_014169:1740243:176019717601971760886690Bifidobacterium longum subsp. longum JDM301 chromosome, completeuracil-DNA glycosylase6e-45180
NC_008752:620802:639828639828640553726Acidovorax avenae subsp. citrulli AAC00-1, complete genomeuracil-DNA glycosylase4e-43174
NC_014643:609544:629218629218629892675Rothia dentocariosa ATCC 17931 chromosome, complete genomeuracil-DNA glycosylase5e-43174
NC_009480:1261961:128211712821171282803687Clavibacter michiganensis subsp. michiganensis NCPPB 382, completeuracil-DNA glycosylase1e-42172
NC_013174:73948:967849678497476693Jonesia denitrificans DSM 20603, complete genomeuracil-DNA glycosylase6e-40164
NC_007777:3962000:397759539775953978273679Frankia sp. CcI3, complete genome7e-1580.9