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Query: NC_008262:2824503:2847557 Clostridium perfringens SM101, complete genome

Start: 2847557, End: 2848198, Length: 642

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011899:1437981:145379614537961454437642Halothermothrix orenii H 168, complete genomeProtein of unknown function (DUF1121)5e-61233
NC_013517:2633574:264991926499192650557639Sebaldella termitidis ATCC 33386, complete genomeprotein of unknown function DUF11211e-48192
NC_014365:2888897:290339129033912904032642Desulfarculus baarsii DSM 2075 chromosome, complete genomeprotein of unknown function DUF11214e-48191
NC_015152:1230995:123491712349171235597681Spirochaeta sp. Buddy chromosome, complete genomehypothetical protein8e-45179
NC_017068:1143515:117305811730581173687630Selenomonas ruminantium subsp. lactilytica TAM6421, completehypothetical protein2e-43175
NC_009617:3360990:336383733638373364484648Clostridium beijerinckii NCIMB 8052 chromosome, complete genomehypothetical protein5e-42171
NC_014377:210888:231089231089231739651Thermosediminibacter oceani DSM 16646 chromosome, complete genomehypothetical protein4e-42171
NC_015425:841754:846729846729847376648Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein4e-41167
NC_014392:2311243:231400323140032314641639Caldicellulosiruptor obsidiansis OB47 chromosome, complete genomehypothetical protein8e-40163
NC_011661:1542335:155173815517381552379642Dictyoglomus turgidum DSM 6724, complete genomeprotein of unknown function DUF11211e-39163
NC_011297:1357947:136735513673551367996642Dictyoglomus thermophilum H-6-12, complete genomehypothetical protein1e-39163
NC_014657:2236193:225591922559192256557639Caldicellulosiruptor owensensis OL chromosome, complete genomehypothetical protein1e-39162
NC_014624:551510:556650556650557285636Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein3e-33141
NC_016048:2873669:288620428862042886881678Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein2e-27122
NC_018607:2472250:249508424950842495713630Brachyspira pilosicoli B2904 chromosome, complete genomehypothetical protein4e-27121
NC_019908:1565500:158679815867981587427630Brachyspira pilosicoli P43/6/78 chromosome, complete genomehypothetical protein4e-27120
NC_016048:2167440:217320221732022173807606Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein1e-25116
NC_014166:1179335:118123211812321181882651Arcobacter nitrofigilis DSM 7299 chromosome, complete genomehypothetical protein1e-25116
NC_017187:1511567:151156715115671512166600Arcobacter butzleri ED-1, complete genomehypothetical protein6e-25114
NC_014011:527681:533853533853534506654Aminobacterium colombiense DSM 12261 chromosome, complete genomeprotein of unknown function DUF11214e-24111
NC_006395:161455:180213180213180869657Haloarcula marismortui ATCC 43049 plasmid pNG700, completehypothetical protein6e-1270.9
NC_015589:2281054:228551622855162286153638Desulfotomaculum ruminis DSM 2154 chromosome, complete genome9e-0857
NC_015949:428923:442443442443442730288Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomehypothetical protein4e-0754.7