Pre_GI: BLASTP Hits

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Query: NC_008262:2824503:2844984 Clostridium perfringens SM101, complete genome

Start: 2844984, End: 2845655, Length: 672

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014377:1943476:197040919704091971092684Thermosediminibacter oceani DSM 16646 chromosome, complete genometransposase IS3/IS911 family protein2e-53208
NC_014377:2033781:204929120492912049974684Thermosediminibacter oceani DSM 16646 chromosome, complete genome2e-51202
NC_016935:1636278:171309717130971713774678Paenibacillus mucilaginosus 3016 chromosome, complete genometransposase IS3/IS911 family protein1e-45182
NC_016935:2347691:242852924285292429206678Paenibacillus mucilaginosus 3016 chromosome, complete genometransposase IS3/IS911 family protein1e-45182
NC_016935:2503071:252415025241502524827678Paenibacillus mucilaginosus 3016 chromosome, complete genometransposase IS3/IS911 family protein1e-45182
NC_016935:3103430:312271331227133123390678Paenibacillus mucilaginosus 3016 chromosome, complete genometransposase IS3/IS911 family protein1e-45182
NC_016935:4038265:405431340543134054990678Paenibacillus mucilaginosus 3016 chromosome, complete genometransposase IS3/IS911 family protein1e-45182
NC_017068:2436960:244113124411312441802672Selenomonas ruminantium subsp. lactilytica TAM6421, completeputative transposase OrfA2e-43175
NC_012470:1390285:139911513991151399846732Streptococcus equi subsp. zooepidemicus, complete genometransposase9e-42169
NC_015589:814530:822886822886823569684Desulfotomaculum ruminis DSM 2154 chromosome, complete genometransposase IS3/IS911 family protein2e-41169
NC_015737:2288032:230300323030032303686684Clostridium sp. SY8519, complete genomehypothetical protein1e-36152
NC_015760:8914:253182531825995678Streptococcus salivarius CCHSS3, complete genometransposase1e-31136
NC_017337:2588331:259075025907502591505756Staphylococcus aureus subsp. aureus ED133 chromosome, completeputative insertion element protein5e-31134
NC_002952:2390668:239185323918532392608756Staphylococcus aureus subsp. aureus MRSA252, complete genomeputative insertion element protein9e-31133
NC_010999:561914:578205578205578933729Lactobacillus casei, complete genomeISSth1, transposase (Orf1), IS3 family3e-29128
NC_010610:1765000:177353517735351774149615Lactobacillus fermentum IFO 3956, complete genomeputative transposase2e-24112
NC_010610:1765000:178341617834161784108693Lactobacillus fermentum IFO 3956, complete genomeCOG29632e-24112
NC_004567:1089231:108923110892311089578348Lactobacillus plantarum WCFS1, complete genometransposase, fragment (putative)1e-1789.7
NC_004567:1089231:110490811049081105195288Lactobacillus plantarum WCFS1, complete genomehypothetical protein9e-1270.5
NC_014500:2688095:270154727015472702068522Dickeya dadantii 3937 chromosome, complete genomeISEch2 OrfA2e-0859.3
NC_015697:256000:2562112562112576291419Lactobacillus reuteri SD2112 chromosome, complete genomeIS3 family transposase ISLasa5a2e-0755.8
NC_015275:654959:669678669678670256579Clostridium lentocellum DSM 5427 chromosome, complete genometransposase IS3/IS911 family protein2e-0755.8
NC_015697:1814128:1853485185348518550411557Lactobacillus reuteri SD2112 chromosome, complete genomeIS3 family transposase ISLasa5a3e-0755.5
NC_015978:1266196:127273012727301273266537Lactobacillus sanfranciscensis TMW 1.1304 chromosome, completehypothetical protein4e-0755.1
NC_015978:996933:101166810116681012171504Lactobacillus sanfranciscensis TMW 1.1304 chromosome, completehypothetical protein1e-0653.5
NC_004567:1089231:110522511052251105605381Lactobacillus plantarum WCFS1, complete genomehypothetical protein2e-0652.8
NC_015978:996933:102134510213451021848504Lactobacillus sanfranciscensis TMW 1.1304 chromosome, completehypothetical protein2e-0652.4