Pre_GI: BLASTP Hits

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Query: NC_008262:2824503:2841969 Clostridium perfringens SM101, complete genome

Start: 2841969, End: 2844620, Length: 2652

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016935:1365463:1423474142347414283094836Paenibacillus mucilaginosus 3016 chromosome, complete genomeprotein BglA26e-129462
NC_015690:3941113:4004066400406640089014836Paenibacillus mucilaginosus KNP414 chromosome, complete genomeBglA22e-128460
NC_010001:4128034:4140411414041141454955085Clostridium phytofermentans ISDg, complete genomeGlucan endo-1,3-beta-D-glucosidase5e-86319
NC_006582:755294:769595769595770437843Bacillus clausii KSM-K16, complete genomeendo-beta-1,3-glucanase9e-65249
NC_011899:437298:4503544503544542263873Halothermothrix orenii H 168, complete genomeGlucan endo-1,3-beta-D-glucosidase3e-62240
NC_014720:154111:1859811859811926706690Caldicellulosiruptor kronotskyensis 2002 chromosome, completeglycoside hydrolase family 163e-58227
NC_011899:437298:445222445222446067846Halothermothrix orenii H 168, complete genomeglycoside hydrolase family 161e-51205
NC_019897:1224798:1224798122479812260541257Thermobacillus composti KWC4 chromosome, complete genomebeta-glucanase/beta-glucan synthetase3e-49197
NC_012883:287965:311958311958312917960Thermococcus sibiricus MM 739, complete genomeLaminarinase (endo-beta-1,3-glucanase) (extracellular)4e-47190
NC_015953:3227000:3229461322946132307561296Streptomyces sp. SirexAA-E chromosome, complete genomeglycoside hydrolase family protein4e-46187
NC_009718:1736300:174826717482671749133867Fervidobacterium nodosum Rt17-B1, complete genomeglucan endo-1,3-beta-D-glucosidase1e-45185
NC_014720:154111:1594781594781667857308Caldicellulosiruptor kronotskyensis 2002 chromosome, completeglycoside hydrolase family 162e-45185
NC_009615:3638451:366173636617363662566831Parabacteroides distasonis ATCC 8503 chromosome, complete genomebeta-glycosidase8e-41169
NC_015844:1188360:1207535120753512089831449Zobellia galactanivorans, complete genomeendo-1,3-beta-glucanase3e-39164
NC_007677:3505487:3517423351742335185381116Salinibacter ruber DSM 13855, complete genomebeta-glucanase precursor1e-38162
NC_014032:3573920:3585256358525635863801125Salinibacter ruber M8 chromosome, complete genomebeta-glucanase2e-38161
NC_013132:6385223:6385223638522363884023180Chitinophaga pinensis DSM 2588, complete genomeLicheninase5e-38160
NC_014318:5586287:561343956134395614296858Amycolatopsis mediterranei U32 chromosome, complete genomesecreted glucosidase3e-30134
NC_010655:854152:855308855308856180873Akkermansia muciniphila ATCC BAA-835, complete genomeGlucan endo-1,3-beta-D-glucosidase5e-29130
NC_006347:1815687:183925518392551840127873Bacteroides fragilis YCH46, complete genomebeta-glucanase precursor2e-28128
NC_021182:338428:3576193576193588391221Clostridium pasteurianum BC1, complete genomebeta-glucanase/beta-glucan synthetase1e-25119
NC_013440:5944935:5960128596012859613451218Haliangium ochraceum DSM 14365, complete genomeglycoside hydrolase family 161e-24115
NC_015577:1289975:129830912983091299256948Treponema azotonutricium ZAS-9 chromosome, complete genomeglucan endo-1,3-beta-D-glucosidase1e-23112
NC_008825:747756:750765750765751652888Methylibium petroleiphilum PM1, complete genomebeta-glucanase/beta-glucan synthetase-like protein2e-23112
NC_015433:791364:7913647913647956234260Streptococcus suis ST3 chromosome, complete genomeLPXTG-motif cell wall anchor domain-containing protein4e-23110
NC_007777:4597379:4603463460346346045031041Frankia sp. CcI3, complete genomeglycoside hydrolase, family 161e-20102
NC_004663:3502745:3515351351535135164691119Bacteroides thetaiotaomicron VPI-5482, complete genomebeta-glucanase precursor2e-20101
NC_013757:421760:4225494225494246242076Geodermatophilus obscurus DSM 43160, complete genomeglycoside hydrolase family 162e-1378.6
NC_010556:316996:344965344965345912948Exiguobacterium sibiricum 255-15, complete genomeCarbohydrate-binding CenC domain protein2e-1171.6
NC_013162:1176000:119699111969911197776786Capnocytophaga ochracea DSM 7271, complete genomeglycoside hydrolase family 166e-1170.5
NC_019974:3465496:348611734861173487040924Natronococcus occultus SP4, complete genomebeta-glucanase/beta-glucan synthetase2e-1068.9
NC_017955:479929:4845414845414866522112Modestobacter marinus, complete genomeglycoside hydrolase family 161e-0863.2
NC_016582:11734963:1174819311748193117494011209Streptomyces bingchenggensis BCW-1 chromosome, complete genomeglycoside hydrolase family protein1e-0759.3
NC_014008:1246642:1259430125943012606201191Coraliomargarita akajimensis DSM 45221 chromosome, complete genomeglycoside hydrolase family 166e-0757
NC_010067:3056774:3057838305783830592141377Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein7e-0757
NC_010397:1802724:183975218397521840549798Mycobacterium abscessus chromosome Chromosome, complete sequencePutative beta-glucanase1e-0656.2
NC_017904:2724941:273079927307992731647849Mycobacterium sp. MOTT36Y chromosome, complete genomeglycosyl hydrolase family protein 162e-0655.5
NC_010804:671081:687883687883688752870Burkholderia multivorans ATCC 17616 chromosome 1, completeputative glycoside hydrolase3e-0654.7
NC_013131:7945280:7975935797593579778211887Catenulispora acidiphila DSM 44928, complete genomeglycoside hydrolase family 165e-0654.3
NC_010084:2822295:283631528363152836890576Burkholderia multivorans ATCC 17616 chromosome 1, completeglycoside hydrolase family protein5e-0653.9