Pre_GI: BLASTP Hits

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Query: NC_008262:2824503:2839856 Clostridium perfringens SM101, complete genome

Start: 2839856, End: 2840749, Length: 894

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017295:1228760:125240812524081253286879Clostridium acetobutylicum EA 2018 chromosome, complete genomeTranscriptional regulators of NagC/XylR family1e-21103
NC_003030:1231127:125477512547751255653879Clostridium acetobutylicum ATCC 824, complete genomeTranscriptional regulators of NagC/XylR family1e-21103
NC_015687:1230948:125459612545961255474879Clostridium acetobutylicum DSM 1731 chromosome, complete genomeNagC/XylR family transcriptional regulator1e-21103
NC_008262:2242432:226576922657692266662894Clostridium perfringens SM101, complete genomeROK family protein6e-21101
NC_009328:3322802:335427933542793355181903Geobacillus thermodenitrificans NG80-2 chromosome, complete genomesugar kinase4e-1995.5
NC_003210:2879906:288203328820332882938906Listeria monocytogenes EGD-e, complete genomehypothetical protein7e-1891.3
NC_019896:1989997:199384819938481994816969Bacillus subtilis subsp. subtilis str. BSP1 chromosome, completetranscriptional regulator7e-1788.2
NC_020291:5808856:583843658384365839314879Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeglucokinase GlcK6e-1685.1
NC_013515:1125739:113758411375841138435852Streptobacillus moniliformis DSM 12112, complete genomeROK family protein7e-1684.7
NC_012984:3077004:308065730806573081520864Lactobacillus plantarum JDM1, complete genomesugar kinase and transcription regulator2e-1480.1
NC_015875:646000:664115664115665074960Streptococcus pseudopneumoniae IS7493 chromosome, complete genomeglucokinase2e-1480.1
NC_006677:295253:299731299731300666936Gluconobacter oxydans 621H, complete genomePutative sugar kinase/putative transcriptional regulator2e-1480.1
NC_015389:616430:615525615525616433909Coriobacterium glomerans PW2 chromosome, complete genomeROK family protein5e-1478.6
NC_014494:614809:633177633177634136960Streptococcus pneumoniae AP200 chromosome, complete genomehypothetical protein6e-1478.2
NC_012466:590883:605717605717606676960Streptococcus pneumoniae JJA, complete genomeglucokinase (Glucose kinase)6e-1478.2
NC_008533:592000:607682607682608641960Streptococcus pneumoniae D39, complete genomeglucokinase6e-1478.2
NC_010582:620400:633043633043634020978Streptococcus pneumoniae CGSP14, complete genomeglucokinase6e-1478.2
NC_003098:586941:600133600133601110978Streptococcus pneumoniae R6, complete genomeGlucose kinase6e-1478.2
NC_018643:320197:339286339286340188903Alpha proteobacterium HIMB5 chromosome, complete genomeROK family kinase1e-1377.4
NC_002570:832480:853749853749854657909Bacillus halodurans C-125, complete genometranscriptional regulator1e-1377.4
NC_011900:2107133:211430921143092115178870Streptococcus pneumoniae ATCC 700669, complete genomeROK family protein2e-1377
NC_013853:2048867:205074120507412051622882Streptococcus mitis B6, complete genomeROK family protein2e-1376.6
NC_012466:2008000:201370620137062014587882Streptococcus pneumoniae JJA, complete genomeROK family protein3e-1375.9
NC_014498:2127000:213066321306632131532870Streptococcus pneumoniae 670-6B chromosome, complete genomeROK family protein3e-1375.9
NC_012785:1988527:200581720058172006761945Kosmotoga olearia TBF 19.5.1, complete genomeROK family protein3e-1375.9
NC_012468:2069238:207494120749412075810870Streptococcus pneumoniae 70585, complete genomeROK family protein5e-1375.5
NC_009457:2764972:280080828008082801788981Vibrio cholerae O395 chromosome 2, complete sequenceROK family protein4e-1375.5
NC_012578:224559:260401260401261381981Vibrio cholerae M66-2 chromosome I, complete sequenceROK family protein4e-1375.5
NC_015389:1977736:199562019956201996423804Coriobacterium glomerans PW2 chromosome, complete genomeROK family protein4e-1375.5
NC_010582:2091138:209918120991812100062882Streptococcus pneumoniae CGSP14, complete genomeROK family protein6e-1375.1
NC_015389:2030154:206420320642032065150948Coriobacterium glomerans PW2 chromosome, complete genomeROK family protein7e-1374.7
NC_003098:1925783:193177419317741932655882Streptococcus pneumoniae R6, complete genomehypothetical protein8e-1374.7
NC_008533:1935500:193927619392761940145870Streptococcus pneumoniae D39, complete genomeROK family protein9e-1374.3
NC_015389:1858732:187294518729451873862918Coriobacterium glomerans PW2 chromosome, complete genomeROK family protein1e-1273.9
NC_012467:1997484:200535720053572006226870Streptococcus pneumoniae P1031, complete genomeROK family protein1e-1273.9
NC_016783:429162:451771451771452655885Corynebacterium diphtheriae INCA 402 chromosome, complete genomeputative regulatory protein sugar kinase1e-1273.9
NC_020291:5808856:583589758358975836799903Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genometranscriptional regulator/sugar kinase2e-1273.6
NC_009785:130252:131203131203132087885Streptococcus gordonii str. Challis substr. CH1, complete genomeglucokinase2e-1273.6
NC_012781:2802000:281534528153452816289945Eubacterium rectale ATCC 33656, complete genometranscriptional regulator/sugar kinase2e-1273.2
NC_016111:5181475:5180324518032451814781155Streptomyces cattleya NRRL 8057, complete genomeglucokinase4e-1272.4
NC_008261:64678:908979089791844948Clostridium perfringens ATCC 13124, complete genomeputative glucokinase3e-1272.4
NC_016445:2663837:269969326996932700661969Vibrio cholerae O1 str. 2010EL-1786 chromosome 1, completefructokinase4e-1272
NC_014538:73272:934669346694413948Thermoanaerobacter sp. X513 chromosome, complete genomeglucokinase, ROK family7e-1271.2
NC_014964:2199252:220169322016932202640948Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completeglucokinase, ROK family7e-1271.2
NC_010320:33814:536015360154548948Thermoanaerobacter sp. X514 chromosome, complete genomeROK family glucokinase7e-1271.2
NC_010321:2207364:221454822145482215495948Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeROK family glucokinase7e-1271.2
NC_012913:626449:629888629888630802915Aggregatibacter aphrophilus NJ8700, complete genomeN-acetyl-D-glucosamine kinase (GlcNAc kinase)9e-1270.9
NC_014963:558000:568303568303569238936Terriglobus saanensis SP1PR4 chromosome, complete genomeROK family protein3e-1169.3
NC_015671:1540860:156383715638371564781945Cellvibrio gilvus ATCC 13127 chromosome, complete genomeglucokinase, ROK family1e-1067.4
NC_011978:975333:999005999005999958954Thermotoga neapolitana DSM 4359, complete genomeGlucokinase2e-1066.6
NC_013642:1317114:134237413423741343318945Thermotoga naphthophila RKU-10, complete genomeROK family protein2e-1066.2
NC_010483:1385000:138845913884591389403945Thermotoga sp. RQ2, complete genomeROK family protein2e-1066.2
NC_009486:1293510:131877013187701319714945Thermotoga petrophila RKU-1 chromosome, complete genomeROK family protein2e-1066.2
NC_000853:1480478:148134914813491482302954Thermotoga maritima MSB8, complete genomeglucokinase3e-1065.9
NC_021066:5342127:5350784535078453519381155Raoultella ornithinolytica B6, complete genomexylose operon transcriptional repressor5e-1065.5
NC_013416:1621469:162146916214691622383915Aggregatibacter actinomycetemcomitans D11S-1, complete genomeN-acetyl-D-glucosamine kinase (GlcNAc kinase)1e-0963.9
NC_012491:6143928:615641561564156157413999Brevibacillus brevis NBRC 100599, complete genomeprobable glucokinase2e-0963.5
NC_009828:600349:625474625474626424951Thermotoga lettingae TMO, complete genomeputative glucokinase, ROK family3e-0962.8
NC_020418:1397112:141334114133411414210870Morganella morganii subsp. morganii KT, complete genomeN-acetylmannosamine kinase3e-0962.8
NC_012587:3177583:319923631992363200132897Rhizobium sp. NGR234, complete genomeputative sugar kinase/putative transcriptional regulator3e-0962.8
NC_019960:1658657:165926016592601660219960Prevotella dentalis DSM 3688 chromosome 1, complete sequencetranscriptional regulator/sugar kinase4e-0962.4
NC_014209:136152:149349149349150296948Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,ROK family protein5e-0962
NC_014829:1154520:1167868116786811690911224Bacillus cellulosilyticus DSM 2522 chromosome, complete genomeROK family protein6e-0961.6
NC_010610:1178430:119775411977541198671918Lactobacillus fermentum IFO 3956, complete genometranscriptional regulator7e-0961.6
NC_014364:2562281:257970525797052580640936Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeROK family protein1e-0860.8
NC_014483:195321:209073209073210023951Paenibacillus polymyxa E681 chromosome, complete genomeGlucokinase (Glucose kinase)2e-0860.1
NC_008800:4488112:449321144932114494113903Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,putative ROK family protein4e-0858.9
NC_016785:1357500:138835913883591389120762Corynebacterium diphtheriae CDCE 8392 chromosome, complete genomepolyphosphate glucokinase4e-0858.9
NC_020134:301500:318375318375319337963Clostridium stercorarium subsp. stercorarium DSM 8532, completeglucokinase GlcK5e-0858.5
NC_017243:1558000:157003315700331570989957Brachyspira intermedia PWS/A chromosome, complete genomeROK family protein7e-0858.2
NC_016786:1359064:141047214104721411233762Corynebacterium diphtheriae HC01 chromosome, complete genomepolyphosphate glucokinase2e-0757
NC_016783:1397975:143079914307991431560762Corynebacterium diphtheriae INCA 402 chromosome, complete genomepolyphosphate glucokinase2e-0757
NC_016782:1385800:141020714102071410968762Corynebacterium diphtheriae 241 chromosome, complete genomepolyphosphate glucokinase2e-0757
NC_002935:1378566:142186514218651422626762Corynebacterium diphtheriae NCTC 13129, complete genomepolyphosphate glucokinase2e-0757
NC_016800:1411000:143834914383491439110762Corynebacterium diphtheriae BH8 chromosome, complete genomepolyphosphate glucokinase2e-0757
NC_016787:1350676:140177414017741402535762Corynebacterium diphtheriae HC03 chromosome, complete genomepolyphosphate glucokinase2e-0757
NC_016788:1376000:140523914052391406000762Corynebacterium diphtheriae HC04 chromosome, complete genomepolyphosphate glucokinase2e-0757
NC_016789:1432000:145573914557391456500762Corynebacterium diphtheriae PW8 chromosome, complete genomepolyphosphate glucokinase2e-0757
NC_016790:1345638:137784113778411378602762Corynebacterium diphtheriae VA01 chromosome, complete genomepolyphosphate glucokinase2e-0757
NC_016799:1439000:146201814620181462779762Corynebacterium diphtheriae 31A chromosome, complete genomepolyphosphate glucokinase2e-0757
NC_016801:1422500:145200214520021452763762Corynebacterium diphtheriae C7 (beta) chromosome, complete genomepolyphosphate glucokinase2e-0757
NC_016802:1317365:139499813949981395759762Corynebacterium diphtheriae HC02 chromosome, complete genomepolyphosphate glucokinase2e-0757
NC_015711:3313036:332136833213683322300933Myxococcus fulvus HW-1 chromosome, complete genomeglucokinase2e-0756.6
NC_010001:404066:412380412380413318939Clostridium phytofermentans ISDg, complete genomeglucokinase, ROK family2e-0756.6
NC_010336:213148:236490236490237437948Francisella philomiragia subsp. philomiragia ATCC 25017, completeROK family protein3e-0756.2
NC_013926:511674:511674511674512474801Aciduliprofundum boonei T469 chromosome, complete genomeROK family protein4e-0755.8
NC_016751:1299738:131222013122201313164945Marinitoga piezophila KA3 chromosome, complete genometranscriptional regulator/sugar kinase5e-0755.5
NC_015696:1749863:175568817556881756635948Francisella sp. TX077308 chromosome, complete genomeputative ROK-family transcriptional regulator6e-0755.1
NC_013194:69634:737817378174719939Candidatus Accumulibacter phosphatis clade IIA str. UW-1, completeROK family protein7e-0754.7
NC_015707:705628:713104713104714048945Thermotoga thermarum DSM 5069 chromosome, complete genomeglucokinase9e-0754.7
NC_015519:801929:806377806377807333957Tepidanaerobacter sp. Re1 chromosome, complete genomeROK family glucokinase3e-0653.1
NC_020995:751311:751977751977752948972Enterococcus casseliflavus EC20, complete genomehypothetical protein2e-0653.1
NC_002578:877609:883084883084884058975Thermoplasma acidophilum DSM 1728, complete genomeglucose kinase related protein3e-0652.8
NC_011296:102650:104438104438105391954Thermodesulfovibrio yellowstonii DSM 11347, complete genometranscriptional regulator3e-0652.8
NC_016048:184500:200834200834201790957Oscillibacter valericigenes Sjm18-20, complete genomeputative sugar kinase4e-0652.4
NC_010336:213148:237437237437238402966Francisella philomiragia subsp. philomiragia ATCC 25017, completeROK family protein6e-0652
NC_009457:1444449:148398614839861484849864Vibrio cholerae O395 chromosome 2, complete sequenceN-acetylmannosamine kinase7e-0651.6
NC_012578:1838470:187801618780161878879864Vibrio cholerae M66-2 chromosome I, complete sequenceN-acetylmannosamine kinase7e-0651.6
NC_012582:2013515:201540520154052016268864Vibrio cholerae O395 chromosome chromosome I, complete sequenceROK family protein7e-0651.6
NC_012668:1688500:171576217157621716625864Vibrio cholerae MJ-1236 chromosome 1, complete sequenceN-acetylmannosamine kinase7e-0651.6
NC_016445:1363831:140228314022831403146864Vibrio cholerae O1 str. 2010EL-1786 chromosome 1, completeN-acylmannosamine kinase7e-0651.6
NC_017270:1755552:176961017696101770473864Vibrio cholerae LMA3984-4 chromosome chromosome I, completeN-acetylmannosamine kinase7e-0651.6
NC_017270:1755552:178063617806361781499864Vibrio cholerae LMA3984-4 chromosome chromosome I, completeN-acetylmannosamine kinase7e-0651.6
NC_008601:631504:649296649296650243948Francisella tularensis subsp. novicida U112, complete genomeROK family protein8e-0651.2