Pre_GI: BLASTP Hits

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Query: NC_008262:2824503:2829419 Clostridium perfringens SM101, complete genome

Start: 2829419, End: 2829757, Length: 339

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009848:3582384:359405435940543594392339Bacillus pumilus SAFR-032, complete genomealkylphosphonate uptake protein2e-44177
NC_002932:937157:950991950991951329339Chlorobium tepidum TLS, complete genomePhnA protein4e-44176
NC_011742:4569683:458696845869684587450483Escherichia coli S88 chromosome, complete genomealkylphosphonate uptake protein in phosphonate metabolism1e-43175
CU928145:4695932:471064747106474711129483Escherichia coli 55989 chromosome, complete genomeputative alkylphosphonate uptake protein in phosphonate metabolism1e-43175
NC_011748:4695932:471064747106474711129483Escherichia coli 55989, complete genomeputative alkylphosphonate uptake protein in phosphonate metabolism1e-43175
NC_011750:4719477:473412247341224734604483Escherichia coli IAI39 chromosome, complete genomeputative alkylphosphonate uptake protein in phosphonate metabolism1e-43175
NC_004431:4867648:488493348849334885415483Escherichia coli CFT073, complete genomePhnA protein1e-43175
NC_010498:4656716:467134946713494671762414Escherichia coli SMS-3-5, complete genomealkylphosphonate utilization operon protein PhnA1e-43174
NC_011353:5240020:525604752560475256460414Escherichia coli O157:H7 str. EC4115 chromosome, complete genomealkylphosphonate utilization operon protein PhnA1e-43174
NC_013941:5013695:502961350296135030026414Escherichia coli O55:H7 str. CB9615 chromosome, complete genomealkylphosphonate utilization operon protein PhnA1e-43174
NC_009801:4643000:465779846577984658133336Escherichia coli E24377A, complete genomealkylphosphonate utilization operon protein PhnA2e-43173
NC_007384:4530000:454471145447114545046336Shigella sonnei Ss046, complete genomehypothetical protein2e-43173
NC_002695:5164819:518084751808475181182336Escherichia coli O157:H7 str. Sakai, complete genomehypothetical protein2e-43173
AC_000091:4313167:433107743310774331412336Escherichia coli W3110 DNA, complete genomepredicted phosphonate metabolizing protein2e-43173
CP002516:4431235:443386444338644434199336Escherichia coli KO11, complete genomealkylphosphonate utilization operon protein PhnA2e-43173
NC_008253:4541915:455849945584994558834336Escherichia coli 536, complete genomePhnA protein2e-43173
CU928160:4395156:440976144097614410096336Escherichia coli IAI1 chromosome, complete genomeconserved hypothetical protein2e-43173
NC_009800:4332229:435041943504194350754336Escherichia coli HS, complete genomealkylphosphonate utilization operon protein PhnA2e-43173
NC_010468:4305105:430773543077354308070336Escherichia coli ATCC 8739, complete genomealkylphosphonate utilization operon protein PhnA2e-43173
NC_000913:4307471:432442243244224324757336Escherichia coli K12, complete genomehypothetical protein2e-43173
AP010958:5022196:503698250369825037317336Escherichia coli O103:H2 str. 12009 DNA, complete genomeconserved predicted protein2e-43173
NC_002655:5194804:521083252108325211167336Escherichia coli O157:H7 EDL933, complete genomehypothetical protein2e-43173
NC_010473:4409492:442478444247844425119336Escherichia coli str. K-12 substr. DH10B, complete genomehypothetical protein2e-43173
NC_007606:3842708:384689238468923847227336Shigella dysenteriae Sd197, complete genomehypothetical protein2e-43173
NC_016902:4431235:443386444338644434199336Escherichia coli KO11FL chromosome, complete genomealkylphosphonate utilization operon protein PhnA2e-43173
NC_016822:4686971:470163847016384701973336Shigella sonnei 53G, complete genomeputative alkylphosphonate uptake protein in phosphonate metabolism2e-43173
NC_013364:5040268:505850250585025058837336Escherichia coli O111:H- str. 11128, complete genomehypothetical protein2e-43173
NC_013353:5022196:503698250369825037317336Escherichia coli O103:H2 str. 12009, complete genomehypothetical protein2e-43173
NC_013008:5196080:521210852121085212443336Escherichia coli O157:H7 str. TW14359 chromosome, complete genomehypothetical protein2e-43173
NC_012967:4289929:430511343051134305448336Escherichia coli B str. REL606 chromosome, complete genomehypothetical protein2e-43173
NC_012947:4106031:410866041086604108995336Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completehypothetical protein2e-43173
NC_012759:4247865:426315742631574263492336Escherichia coli BW2952 chromosome, complete genomehypothetical protein2e-43173
NC_011741:4395156:440976144097614410096336Escherichia coli IAI1 chromosome, complete genomehypothetical protein2e-43173
NC_011415:4582388:459717545971754597510336Escherichia coli SE11 chromosome, complete genomehypothetical protein2e-43173
CP002185:4566150:458433945843394584674336Escherichia coli W, complete genomealkylphosphonate utilization operon protein PhnA2e-43173
NC_011751:4795928:481195448119544812289336Escherichia coli UMN026 chromosome, complete genomehypothetical protein2e-43173
NC_007613:4156841:417510441751044175439336Shigella boydii Sb227, complete genomehypothetical protein4e-43173
NC_011059:65414:886808868089018339Prosthecochloris aestuarii DSM 271, complete genomealkylphosphonate utilization operon protein PhnA2e-42171
NC_014019:3213599:322727832272783227616339Bacillus megaterium QM B1551 chromosome, complete genomealkylphosphonate utilization operon protein PhnA2e-42170
NC_017138:1812000:181255518125551812893339Bacillus megaterium WSH-002 chromosome, complete genomephosphonoacetate hydrolase protein1e-41168
NC_020064:4125500:412955141295514129886336Serratia marcescens FGI94, complete genomealkylphosphonate utilization operon protein PhnA1e-41168
NC_014103:3212839:322861832286183228956339Bacillus megaterium DSM319 chromosome, complete genomealkylphosphonate utilization operon protein PhnA3e-41166
NC_012997:59407:773617736177696336Teredinibacter turnerae T7901, complete genomealkylphosphonate utilization operon protein PhnA3e-41166
NC_012880:3421500:342618034261803426521342Dickeya dadantii Ech703, complete genomealkylphosphonate utilization operon protein PhnA5e-41166
NC_010995:3745957:377273037727303773068339Cellvibrio japonicus Ueda107, complete genomealkylphosphonate utilization operon protein PhnA6e-41165
NC_012968:435532:453370453370453714345Methylotenera mobilis JLW8, complete genomealkylphosphonate utilization operon protein PhnA2e-40164
NC_013592:1056500:107467910746791075020342Dickeya dadantii Ech586, complete genomealkylphosphonate utilization operon protein PhnA3e-40163
NC_008639:2786447:280526728052672805605339Chlorobium phaeobacteroides DSM 266, complete genomealkylphosphonate utilization operon protein PhnA5e-40162
NC_008095:7614000:761402176140217614362342Myxococcus xanthus DK 1622, complete genomealkylphosphonate utilization operon protein PhnA1e-39161
NC_010694:63654:722977229772635339Erwinia tasmaniensis, complete genomeProbable phosphonoacetate hydrolase2e-38157
NC_013971:73037:816858168582023339Erwinia amylovora ATCC 49946 chromosome, complete genomephosphonoacetate hydrolase9e-38155
NC_013961:73037:816858168582023339Erwinia amylovora, complete genomeProtein phnA9e-38155
NC_012846:1679184:170139817013981701733336Bartonella grahamii as4aup, complete genomealkylphosphonate uptakeprotein3e-36150
NC_010524:4788753:479328247932824793623342Leptothrix cholodnii SP-6, complete genomealkylphosphonate utilization operon protein PhnA8e-36148
NC_011761:1904637:191253519125351912876342Acidithiobacillus ferrooxidans ATCC 23270 chromosome, completealkylphosphonate utilization operon protein PhnA3e-35147
NC_011206:1792621:179818117981811798522342Acidithiobacillus ferrooxidans ATCC 53993, complete genomealkylphosphonate utilization operon protein PhnA3e-35147
NC_014550:301894:314485314485314832348Arthrobacter arilaitensis Re117, complete genomeputative PhnA protein6e-34142
NC_012779:2755338:276679227667922767073282Edwardsiella ictaluri 93-146, complete genomeputative alkylphosphonate utilization operon protein PhnA5e-34142
NC_009901:1516340:152201115220111522352342Shewanella pealeana ATCC 700345, complete genomealkylphosphonate utilization operon protein PhnA3e-33140
NC_010334:1561691:156730315673031567644342Shewanella halifaxensis HAW-EB4, complete genomealkylphosphonate utilization operon protein PhnA3e-33140
NC_014932:1232346:128082112808211281159339Bartonella clarridgeiae 73, complete genomealkylphosphonate utilization operon protein PhnA4e-32136
NC_016745:2280375:228732722873272287665339Oceanimonas sp. GK1 chromosome, complete genomehypothetical protein2e-30130
NC_016513:1529691:153689315368931537216324Aggregatibacter actinomycetemcomitans ANH9381 chromosome, completealkylphosphonate utilization operon protein PhnA2e-29127
NC_007952:1416000:143644014364401436781342Burkholderia xenovorans LB400 chromosome 2, complete sequencePhnA protein2e-26117
NC_012724:1914740:193655919365591936903345Burkholderia glumae BGR1 chromosome 1, complete genomeAlkylphosphonate utilization operon protein PhnA5e-26116
NC_018645:3719302:372296437229643723314351Desulfobacula toluolica Tol2, complete genomealkylphosphate uptake protein PhnA9e-25112
NC_016147:1788219:181126618112661811601336Pseudoxanthomonas spadix BD-a59 chromosome, complete genomephosphonoacetate hydrolase3e-22103
NC_013172:2556517:256055625605562560927372Brachybacterium faecium DSM 4810, complete genomealkylphosphonate utilization operon protein PhnA2e-1994
NC_009004:2477220:248151224815122481877366Lactococcus lactis subsp. cremoris MG1363, complete genomeputative alkylphosphonate uptake protein6e-1682.8
NC_015709:1459838:150455015045501504855306Zymomonas mobilis subsp. pomaceae ATCC 29192 chromosome, completePhnA protein4e-1580.1
NC_021177:1736854:176393617639361764181246Streptomyces fulvissimus DSM 40593, complete genomeAlkilphosphonate uptake protein6e-1476.3
NC_014935:1389000:138934913893491389915567Nitratifractor saLSUginis DSM 16511 chromosome, complete genomephna protein2e-1374.3
NC_009719:1135523:116179411617941162009216Parvibaculum lavamentivorans DS-1 chromosome, complete genomePhnA protein3e-1373.9
NC_015945:1908895:190829019082901908898609Muricauda ruestringensis DSM 13258 chromosome, complete genomePhnA protein6e-0959.3
NC_008321:3189974:321021032102103210773564Shewanella sp. MR-4, complete genomePhnA protein2e-0857.8