Pre_GI: BLASTP Hits

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Query: NC_008262:2824503:2824503 Clostridium perfringens SM101, complete genome

Start: 2824503, End: 2826659, Length: 2157

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012658:1052957:1052957105295710551162160Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative phage infection protein0770
NC_010520:1146000:1148522114852211506812160Clostridium botulinum A3 str. Loch Maree, complete genomeputative phage infection protein0761
NC_021182:1045218:1050711105071110528882178Clostridium pasteurianum BC1, complete genomeYhgE/Pip-like protein0680
NC_008262:2824503:2826682282668228288472166Clostridium perfringens SM101, complete genomephage infection protein, putative2e-145517
NC_021182:1045218:1048522104852210506902169Clostridium pasteurianum BC1, complete genomeYhgE/Pip-like protein1e-142507
NC_010520:1146000:1146146114614611483142169Clostridium botulinum A3 str. Loch Maree, complete genomeputative phage infection protein1e-137490
NC_014328:3482980:3507895350789535100572163Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative phage infection protein2e-129463
NC_004307:1701071:1722980172298017257182739Bifidobacterium longum NCC2705, complete genomehypothetical protein with similarity to pip phage infection protein of L. lactis2e-81303
NC_017218:2223604:2220863222086322236072745Bifidobacterium breve ACS-071-V-Sch8b chromosome, complete genomehypothetical protein9e-81301
NC_017218:2223604:2223604222360422259462343Bifidobacterium breve ACS-071-V-Sch8b chromosome, complete genomehypothetical protein8e-72272
NC_004307:1701071:1720644172064417229832340Bifidobacterium longum NCC2705, complete genomehypothetical protein with similarity to pip phage infection protein of L. lactis3e-71270
NC_015958:84270:8689086890891062217Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomeYhgE/Pip C-terminal domain-containing protein1e-52208
NC_009480:739395:7570507570507591552106Clavibacter michiganensis subsp. michiganensis NCPPB 382, completehypothetical protein1e-34148
NC_016932:1246235:1249033124903312510542022Corynebacterium pseudotuberculosis 316 chromosome, complete genomehypothetical protein6e-32139
NC_014329:1261480:1264278126427812662992022Corynebacterium pseudotuberculosis FRC41 chromosome, completehypothetical protein1e-31138
NC_016781:1261300:1264098126409812661192022Corynebacterium pseudotuberculosis 3/99-5 chromosome, completehypothetical protein1e-31138
NC_017031:1261289:1264087126408712661082022Corynebacterium pseudotuberculosis P54B96 chromosome, completehypothetical protein1e-31138
NC_017300:1258861:1261659126165912636802022Corynebacterium pseudotuberculosis 1002 chromosome, completehypothetical protein1e-31138
NC_017301:1261167:1263965126396512659862022Corynebacterium pseudotuberculosis C231 chromosome, completehypothetical protein1e-31138
NC_017303:1261311:1264109126410912661302022Corynebacterium pseudotuberculosis I19 chromosome, complete genomehypothetical protein1e-31138
NC_017305:1258840:1261638126163812636592022Corynebacterium pseudotuberculosis PAT10 chromosome, completehypothetical protein1e-31138
NC_018720:176306:2202582202582216041347Bifidobacterium asteroides PRL2011 chromosome, complete genomehypothetical protein1e-29132
NC_020450:875757:8809648809648833632400Lactococcus lactis subsp. lactis IO-1 DNA, complete genomehypothetical protein1e-26122
NC_015737:1441086:1454059145405914568572799Clostridium sp. SY8519, complete genomehypothetical protein2e-26121
NC_007164:822000:8255248255248276562133Corynebacterium jeikeium K411, complete genomehypothetical protein5e-23110
NC_014831:1843835:1859411185941118617112301Thermaerobacter marianensis DSM 12885 chromosome, complete genomeYhgE/Pip C-terminal domain protein2e-1895.1
NC_013715:193647:2034322034322060382607Rothia mucilaginosa DY-18, complete genomepredicted membrane protein5e-1790.1
NC_001263:72681:7268172681770844404Deinococcus radiodurans R1 chromosome 1, complete sequencehypothetical protein5e-1790.1
NC_016785:1321700:1328810132881013308312022Corynebacterium diphtheriae CDCE 8392 chromosome, complete genomehypothetical protein2e-1378.2
NC_016789:1334514:1393035139303513950562022Corynebacterium diphtheriae PW8 chromosome, complete genomehypothetical protein2e-1378.2
NC_016790:1259356:1314028131402813160492022Corynebacterium diphtheriae VA01 chromosome, complete genomehypothetical protein2e-1378.2
NC_016799:1343020:1402679140267914047002022Corynebacterium diphtheriae 31A chromosome, complete genomehypothetical protein2e-1378.2
NC_016802:1317365:1348126134812613501472022Corynebacterium diphtheriae HC02 chromosome, complete genomehypothetical protein2e-1377.8
NC_016801:1361597:1392355139235513943762022Corynebacterium diphtheriae C7 (beta) chromosome, complete genomehypothetical protein2e-1377.8
NC_013174:501326:5166685166685190162349Jonesia denitrificans DSM 20603, complete genomeYhgE/Pip N-terminal domain protein7e-1376.3
NC_016011:59070:5907059070623003231Listeria ivanovii subsp. ivanovii PAM 55, complete genomeputative YueB protein5e-1170.1
NC_008010:1:1454614546176593114Deinococcus geothermalis DSM 11300 plasmid 1, complete sequencehypothetical protein6e-1169.7
NC_015660:487506:4875064875064902922787Geobacillus thermoglucosidasius C56-YS93 chromosome, completehypothetical protein8e-1066.2
NC_014650:475662:4756624756624784482787Geobacillus sp. Y4.1MC1 chromosome, complete genomehypothetical protein1e-0965.9
NC_015634:959396:9558649558649594213558Bacillus coagulans 2-6 chromosome, complete genomehypothetical protein9e-0962.8
NC_016023:267581:2855502855502889513402Bacillus coagulans 36D1 chromosome, complete genomehypothetical protein1e-0862.8
NC_009328:448224:4767354767354795152781Geobacillus thermodenitrificans NG80-2 chromosome, complete genomehypothetical protein2e-0758.2
NC_004193:1335626:1357564135756413610853522Oceanobacillus iheyensis HTE831, complete genomehypothetical protein3e-0654.7
NC_020291:231853:2363192363192386942376Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein5e-0653.5