Pre_GI: BLASTP Hits

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Query: NC_008262:2348328:2363978 Clostridium perfringens SM101, complete genome

Start: 2363978, End: 2364574, Length: 597

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009922:2672396:267422426742242674838615Alkaliphilus oremlandii OhILAs, complete genomeconserved hypothetical protein2e-33142
NC_014387:719245:720656720656721438783Butyrivibrio proteoclasticus B316 chromosome 1, complete genomehypothetical protein4e-31134
NC_016630:1610723:162817116281711628785615Filifactor alocis ATCC 35896 chromosome, complete genomemembrane protein5e-30130
NC_012781:751757:756213756213756821609Eubacterium rectale ATCC 33656, complete genomehypothetical protein9e-27119
NC_015555:693461:713110713110713694585Thermoanaerobacterium xylanolyticum LX-11 chromosome, completemembrane protein-like protein protein1e-26119
NC_014377:1897857:190354519035451904162618Thermosediminibacter oceani DSM 16646 chromosome, complete genomehypothetical protein3e-26118
NC_019970:2190695:219646321964632197047585Thermoanaerobacterium thermosaccharolyticum M0795, complete genomehypothetical protein6e-26117
NC_010001:434803:437841437841438587747Clostridium phytofermentans ISDg, complete genomemembrane protein-like protein5e-26117
NC_014410:2149886:215264721526472153231585Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,membrane protein-like protein protein7e-25113
NC_020134:301500:315240315240315872633Clostridium stercorarium subsp. stercorarium DSM 8532, completeriboflavin transporter RibU1e-23109
NC_018704:896209:898458898458899036579Amphibacillus xylanus NBRC 15112, complete genomeriboflavin transporter4e-22104
NC_016894:377446:387974387974388543570Acetobacterium woodii DSM 1030 chromosome, complete genomehypothetical protein2e-1789.4
NC_014376:1472304:147230414723041472981678Clostridium saccharolyticum WM1 chromosome, complete genomehypothetical protein1e-1479.7
NC_006177:2883476:292516129251612925670510Symbiobacterium thermophilum IAM 14863, complete genomehypothetical protein2e-0962