Pre_GI: BLASTP Hits

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Query: NC_008262:2348328:2359082 Clostridium perfringens SM101, complete genome

Start: 2359082, End: 2360221, Length: 1140

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_020291:5808856:5823847582384758249801134Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeputative metallophosphoesterase MppE2e-87322
NC_015697:256000:2673892673892685731185Lactobacillus reuteri SD2112 chromosome, complete genomephosphoesterase4e-28125
NC_007426:1840670:1881876188187618832011326Natronomonas pharaonis DSM 2160, complete genomehypothetical protein6e-27122
NC_012791:4794362:4842679484267948439681290Variovorax paradoxus S110 chromosome 1, complete genomemetallophosphoesterase3e-25116
NC_014151:3611956:3643837364383736449431107Cellulomonas flavigena DSM 20109 chromosome, complete genomemetallophosphoesterase1e-24114
NC_015580:293803:3141023141023153791278Novosphingobium sp. PP1Y, complete genomemetallophosphoesterase2e-24113
NC_014307:939601:9700499700499713051257Ralstonia solanacearum CFBP2957 chromosome, complete genomemetallophosphoesterase2e-24113
NC_021184:592501:5990735990736003831311Desulfotomaculum gibsoniae DSM 7213, complete genomeDNA repair exonuclease2e-23110
NC_010162:9987367:1001076310010763100120221260Sorangium cellulosum 'So ce 56', complete genomeDNA repair exonuclease family protein3e-23109
NC_013854:513196:5379015379015391631263Azospirillum sp. B510, complete genomephosphoesterase3e-23109
NC_019673:6259229:6261793626179362630251233Saccharothrix espanaensis DSM 44229 complete genomeMetallophosphoesterase4e-23109
NC_013131:6329438:6352696635269663539731278Catenulispora acidiphila DSM 44928, complete genomemetallophosphoesterase7e-23108
NC_007514:1475323:1478952147895214802561305Chlorobium chlorochromatii CaD3, complete genomeputative exonuclease6e-23108
NC_013204:34782:3478234782360681287Eggerthella lenta DSM 2243, complete genomemetallophosphoesterase8e-22104
NC_014727:1512546:1514969151496915161741206Lactobacillus delbrueckii subsp. bulgaricus ND02 chromosome,DNA repair exonuclease2e-21103
NC_011666:2435438:2452554245255424537921239Methylocella silvestris BL2, complete genomemetallophosphoesterase7e-21101
NC_007644:469181:4836624836624847861125Moorella thermoacetica ATCC 39073, complete genomeMetallophosphoesterase1e-1894.4
NC_008095:5585346:5593616559361655947431128Myxococcus xanthus DK 1622, complete genomemetallophosphoesterase5e-1582.4
NC_011901:1860887:1870046187004618711791134Thioalkalivibrio sulfidophilus HL-EbGr7 chromosome, completemetallophosphoesterase1e-1481.3
NC_009663:738846:7422337422337433541122Sulfurovum sp. NBC37-1, complete genomeDNA double-strand break repair protein2e-1480.5
NC_008578:889907:9121809121809135171338Acidothermus cellulolyticus 11B, complete genomemetallophosphoesterase5e-1479
NC_016932:832748:8575558575558586731119Corynebacterium pseudotuberculosis 316 chromosome, complete genomeExonuclease, SbcD-family1e-1378.2
NC_014329:844622:8694418694418705591119Corynebacterium pseudotuberculosis FRC41 chromosome, completehypothetical protein9e-1478.2
NC_016781:844613:8694328694328705501119Corynebacterium pseudotuberculosis 3/99-5 chromosome, completeexonuclease, SbcD-family9e-1478.2
NC_017300:863898:8693378693378704551119Corynebacterium pseudotuberculosis 1002 chromosome, completeExonuclease, SbcD-family9e-1478.2
NC_017031:863093:8692858692858704031119Corynebacterium pseudotuberculosis P54B96 chromosome, completeExonuclease, SbcD-family9e-1478.2
NC_017301:863500:8690598690598701771119Corynebacterium pseudotuberculosis C231 chromosome, completeExonuclease, SbcD-family9e-1478.2
NC_017303:863060:8692528692528703701119Corynebacterium pseudotuberculosis I19 chromosome, complete genomeExonuclease, SbcD-family9e-1478.2
NC_017305:863072:8692648692648703821119Corynebacterium pseudotuberculosis PAT10 chromosome, completeExonuclease, SbcD-family9e-1478.2
NC_017317:944218:9481499481499492671119Corynebacterium ulcerans 809 chromosome, complete genomehypothetical protein3e-1376.6
NC_015683:947048:9509799509799520971119Corynebacterium ulcerans BR-AD22 chromosome, complete genomehypothetical protein3e-1376.6
NC_015931:1443447:1451754145175414529081155Pyrolobus fumarii 1A, complete genomemetallophosphoesterase3e-1273.2
NC_014762:1204584:1220780122078012219101131Sulfuricurvum kujiense DSM 16994 chromosome, complete genomemetallophosphoesterase1e-1171.2
NC_014002:1772060:1777375177737517787301356Methanohalophilus mahii DSM 5219 chromosome, complete genomemetallophosphoesterase1e-1171.2
NC_009718:799431:8193958193958205881194Fervidobacterium nodosum Rt17-B1, complete genomemetallophosphoesterase4e-1169.3
NC_017506:1660072:1658954165895416600751122Marinobacter adhaerens HP15 chromosome, complete genomemetallophosphoesterase1e-1067.8
NC_019977:65205:6829868298696801383Methanomethylovorans hollandica DSM 15978, complete genomeDNA repair exonuclease9e-1065.1
NC_011126:992994:1012323101232310134651143Hydrogenobaculum sp. Y04AAS1, complete genomenuclease SbcCD, D subunit2e-0963.9
NC_017187:1564403:1583344158334415844621119Arcobacter butzleri ED-1, complete genomemetallophosphoesterase2e-0963.5
NC_017187:1580988:1583344158334415844621119Arcobacter butzleri ED-1, complete genomemetallophosphoesterase2e-0963.5
NC_014122:726070:7350717350717362641194Methanocaldococcus infernus ME chromosome, complete genomemetallophosphoesterase5e-0962.8
NC_013861:3341955:3350769335076933519021134Legionella longbeachae NSW150, complete genomemetallophosphoesterase1e-0861.2
NC_007955:1566189:1582148158214815836051458Methanococcoides burtonii DSM 6242, complete genomemetallophosphoesterase2e-0860.8
NC_014253:2113233:2127581212758121290741494Methanohalobium evestigatum Z-7303 chromosome, complete genomemetallophosphoesterase8e-0858.5
NC_013741:27353:4799147991492591269Archaeoglobus profundus DSM 5631, complete genomemetallophosphoesterase2e-0757.4
NC_015676:2099930:2114803211480321161821380Methanosalsum zhilinae DSM 4017 chromosome, complete genomemetallophosphoesterase3e-0756.6
NC_015636:1603664:1610289161028916114791191Methanothermococcus okinawensis IH1 chromosome, complete genomemetallophosphoesterase3e-0756.6
NC_003413:1107965:1113537111353711148231287Pyrococcus furiosus DSM 3638, complete genomeexonuclease putative3e-0756.6
NC_018876:1489895:1503807150380715054081602Methanolobus psychrophilus R15 chromosome, complete genomemetallophosphoesterase2e-0653.9
NC_010085:1090000:1111485111148511127321248Nitrosopumilus maritimus SCM1, complete genomemetallophosphoesterase2e-0653.9
NC_015416:2723189:2733042273304227341901149Methanosaeta concilii GP-6 chromosome, complete genomeSer/Thr protein phosphatase family protein2e-0653.5
NC_013926:974668:9971829971829982701089Aciduliprofundum boonei T469 chromosome, complete genomemetallophosphoesterase3e-0653.1