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Query: NC_008262:101731:104764 Clostridium perfringens SM101, complete genome

Start: 104764, End: 105210, Length: 447

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:64908:914499144991895447Clostridium perfringens str. 13, complete genomeprobable phosphotransbutyrylase5e-79292
NC_020291:6216000:622201662220166222462447Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeVanZ family protein5e-35146
NC_010674:3581044:358670335867033587167465Clostridium botulinum B str. Eklund 17B, complete genomeacetobutylicum phosphotransbutyrylase3e-31133
NC_010723:3395187:340108534010853401543459Clostridium botulinum E3 str. Alaska E43, complete genomeacetobutylicum phosphotransbutyrylase4e-29126
NC_014393:92500:121684121684122133450Clostridium cellulovorans 743B chromosome, complete genomeVanZ family protein8e-26115
NC_011837:3776541:379011237901123790549438Clostridium kluyveri NBRC 12016, complete genomehypothetical protein7e-24109
NC_009706:3845039:385861038586103859047438Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein7e-24109
NC_011830:4722607:472461247246124725079468Desulfitobacterium hafniense DCB-2, complete genomeVanZ family protein2e-1994.7
NC_009253:3272000:327882732788273279297471Desulfotomaculum reducens MI-1 chromosome, complete genomeVanZ family protein2e-1684.7
NC_010723:3434000:344970934497093450176468Clostridium botulinum E3 str. Alaska E43, complete genomeacetobutylicum phosphotransbutyrylase7e-1476.3
NC_003909:4951444:495422649542264954711486Bacillus cereus ATCC 10987, complete genomehypothetical protein3e-1373.6
NC_016771:4962795:496279549627954963280486Bacillus cereus NC7401, complete genomehypothetical protein4e-1373.6
NC_011969:4945441:494544149454414945926486Bacillus cereus Q1 chromosome, complete genomehypothetical protein4e-1373.6
NC_011658:5007691:501047250104725010957486Bacillus cereus AH187 chromosome, complete genomehypothetical protein4e-1373.6
NC_011725:5169135:517195651719565172441486Bacillus cereus B4264 chromosome, complete genomehypothetical protein2e-1271.6
NC_015389:1298689:133095513309551331422468Coriobacterium glomerans PW2 chromosome, complete genomeVanZ family protein1e-0858.9
NC_011978:1500663:152030615203061520821516Thermotoga neapolitana DSM 4359, complete genomeIntegral membrane protein-like protein precursor8e-0855.8
NC_015064:151607:172168172168172746579Acidobacterium sp. MP5ACTX9 chromosome, complete genomeVanZ family protein3e-0650.8
NC_012914:469117:492582492582493121540Paenibacillus sp. JDR-2, complete genomeVanZ family protein4e-0650.4