Pre_GI: BLASTP Hits

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Query: NC_008262:101731:103595 Clostridium perfringens SM101, complete genome

Start: 103595, End: 104701, Length: 1107

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:64908:9028090280913861107Clostridium perfringens str. 13, complete genomeglycogen biosynthesis protein0738
NC_010674:3581044:3594430359443035955361107Clostridium botulinum B str. Eklund 17B, complete genomeglucose-1-phosphate adenylyltransferase, GlgD subunit3e-129461
NC_010723:3395187:3408523340852334096291107Clostridium botulinum E3 str. Alaska E43, complete genomeglucose-1-phosphate adenylyltransferase, GlgD subunit3e-128458
NC_020291:6216000:6238007623800762391071101Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeglycogen biosynthesis protein GlgD1e-126453
NC_014657:473479:4749124749124760541143Caldicellulosiruptor owensensis OL chromosome, complete genomeglucose-1-phosphate adenylyltransferase, glgd subunit1e-90333
NC_014614:1090000:1111162111116211122831122Clostridium sticklandii, complete genomeglycogen biosynthesis protein GlgD1e-88326
NC_011567:388358:4119334119334129551023Anoxybacillus flavithermus WK1, complete genomeADP-glucose pyrophosphorylase3e-63242
NC_014976:1174430:1175881117588111769121032Bacillus subtilis BSn5 chromosome, complete genomeglucose-1-phosphate adenylyltransferase beta subunit1e-62240
NC_004193:375416:4355454355454366511107Oceanobacillus iheyensis HTE831, complete genomeglycogen biosynthesis1e-60234
NC_004193:375416:375416375416675301299886Oceanobacillus iheyensis HTE831, complete genome1e-59230
NC_021171:2562000:2586343258634325873681026Bacillus sp. 1NLA3E, complete genomeglucose-1-phosphate adenylyltransferase, GlgD subunit3e-56219
NC_011653:466007:4741824741824752971116Thermosipho africanus TCF52B, complete genomeglucose-1-phosphate adenylyltransferase, GlgD subunit1e-50200
NC_011567:388358:4107224107224119451224Anoxybacillus flavithermus WK1, complete genomeGlucose-1-phosphate adenylyltransferase2e-39162
NC_004193:375416:4343874343874355441158Oceanobacillus iheyensis HTE831, complete genomeglucose-1-phosphate adenylyltransferase2e-37157
NC_011653:466007:4729324729324741701239Thermosipho africanus TCF52B, complete genomeglucose-1-phosphate adenylyltransferase2e-37156
NC_010674:3581044:3595558359555835967181161Clostridium botulinum B str. Eklund 17B, complete genomeglucose-1-phosphate adenylyltransferase2e-35150
NC_010723:3395187:3409651340965134108111161Clostridium botulinum E3 str. Alaska E43, complete genomeglucose-1-phosphate adenylyltransferase3e-35149
NC_003366:64908:8906989069902501182Clostridium perfringens str. 13, complete genomeglucose-1-phosphate adenylyltransferase3e-35149
NC_020291:6216000:6239134623913462402941161Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeglucose-1-phosphate adenylyltransferase GlgC4e-35149
NC_008262:101731:1023991023991035651167Clostridium perfringens SM101, complete genomeglucose-1-phosphate adenylyltransferase6e-35148
NC_014976:1174430:1176936117693611780781143Bacillus subtilis BSn5 chromosome, complete genomeglucose-1-phosphate adenylyltransferase1e-33144
NC_014171:4708282:4707204470720447083071104Bacillus thuringiensis BMB171 chromosome, complete genomeglucose-1-phosphate adenylyltransferase2e-32140
NC_017208:4845281:4844203484420348453061104Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeglucose-1-phosphate adenylyltransferase2e-32140
NC_014614:1090000:1109967110996711111691203Clostridium sticklandii, complete genomeglucose-1-phosphate adenylyltransferase2e-32139
NC_010556:691498:7103077103077114671161Exiguobacterium sibiricum 255-15, complete genomeglucose-1-phosphate adenylyltransferase6e-31135
NC_014657:473479:4760764760764772541179Caldicellulosiruptor owensensis OL chromosome, complete genomeglucose-1-phosphate adenylyltransferase2e-30133
NC_014032:2440656:2466331246633124676141284Salinibacter ruber M8 chromosome, complete genomeglucose-1-phosphate adenylyltransferase1e-27124
NC_007677:2361049:2386559238655923878421284Salinibacter ruber DSM 13855, complete genomeADP-glucose pyrophosphorylase1e-27124
NC_013889:1623697:1628922162892216301871266Thioalkalivibrio sp. K90mix chromosome, complete genomeglucose-1-phosphate adenylyltransferase6e-25115
NC_011420:2803196:2823850282385028251421293Rhodospirillum centenum SW, complete genomeglucose-1-phosphate adenylyltransferase8e-23108
NC_013946:305364:3215183215183227591242Meiothermus ruber DSM 1279 chromosome, complete genomeglucose-1-phosphate adenylyltransferase1e-22107
NC_012526:1345597:1368300136830013695411242Deinococcus deserti VCD115, complete genomeputative Glucose-1-phosphate adenylyltransferase (ADP-glucose diphosphorylase) (ADP-glucose pyrophosphorylase)1e-22107
NC_012667:703852:7072737072737084961224Vibrio cholerae MJ-1236 chromosome 2, complete genomeglucose-1-phosphate adenylyltransferase1e-22107
NC_015696:1853979:1860088186008818613621275Francisella sp. TX077308 chromosome, complete genomeglucose-1-phosphate adenylyltransferase3e-22106
NC_015850:510837:5381775381775394871311Acidithiobacillus caldus SM-1 chromosome, complete genomeglucose-1-phosphate adenylyltransferase7e-22105
NC_017506:1785872:1806916180691618081811266Marinobacter adhaerens HP15 chromosome, complete genomeglucose-1-phosphate adenylyltransferase2e-21103
NC_014962:3440826:3440826344082634420671242Isosphaera pallida ATCC 43644 chromosome, complete genomeglucose-1-phosphate adenylyltransferase4e-21102
NC_007626:2283793:2283793228379322850821290Magnetospirillum magneticum AMB-1, complete genomeADP-glucose pyrophosphorylase4e-2099
NC_014039:708427:7226617226617239141254Propionibacterium acnes SK137 chromosome, complete genomeglucose-1-phosphate adenylyltransferase7e-2098.6
NC_016511:678582:6959826959826972081227Propionibacterium acnes TypeIA2 P.acn31 chromosome, completeglucose-1-phosphate adenylyltransferase8e-2098.2
NC_016512:679688:6953676953676965931227Propionibacterium acnes TypeIA2 P.acn17 chromosome, completeglucose-1-phosphate adenylyltransferase4e-1995.9
NC_008340:1075500:1095295109529510965631269Alkalilimnicola ehrlichei MLHE-1, complete genomeglucose-1-phosphate adenylyltransferase1e-1894.4
NC_013854:330543:3483733483733496441272Azospirillum sp. B510, complete genomeglucose-1-phosphate adenylyltransferase3e-1892.8
NC_010546:2711929:2726091272609127273801290Cyanothece sp. ATCC 51142 chromosome circular, complete sequenceglucose-1-phosphate adenylyltransferase4e-1892.4
NC_004431:3986472:4004018400401840053491332Escherichia coli CFT073, complete genomeglucose-1-phosphate adenylyltransferase5e-1892.4
NC_008253:3666387:3683932368393236852271296Escherichia coli 536, complete genomeglucose-1-phosphate adenylyltransferase5e-1892
NC_011751:3984236:4001571400157140028661296Escherichia coli UMN026 chromosome, complete genomeglucose-1-phosphate adenylyltransferase5e-1892
NC_011745:3992434:4011071401107140123661296Escherichia coli ED1a chromosome, complete genomeglucose-1-phosphate adenylyltransferase5e-1892
NC_007946:3811082:3830195383019538315261332Escherichia coli UTI89, complete genomeglucose-1-phosphate adenylyltransferase7e-1891.7
NC_008563:3843859:3862979386297938643101332Escherichia coli APEC O1, complete genomeglucose-1-phosphate adenylyltransferase GlgC7e-1891.7
NC_011742:3758618:3777730377773037790251296Escherichia coli S88 chromosome, complete genomeglucose-1-phosphate adenylyltransferase9e-1891.7
NC_007958:396439:3991813991814004551275Rhodopseudomonas palustris BisB5, complete genomeGlucose-1-phosphate adenylyltransferase2e-1790.5
NC_011740:3453455:3473613347361334749081296Escherichia fergusonii ATCC 35469, complete genomeglucose-1-phosphate adenylyltransferase2e-1790.1
NC_009925:2264858:2280898228089822821871290Acaryochloris marina MBIC11017, complete genomeglucose-1-phosphate adenylyltransferase7e-1788.6
NC_015968:4389871:4409691440969144109861296Enterobacter asburiae LF7a chromosome, complete genomeglucose-1-phosphate adenylyltransferase6e-1788.6
NC_012214:3750649:3768824376882437701101287Erwinia pyrifoliae Ep1/96, complete genomeGlucose-1-phosphate adenylyltransferase2e-1686.7
NC_009481:1190301:1192534119253411938291296Synechococcus sp. WH 7803 chromosome, complete genomeglucose-1-phosphate adenylyltransferase2e-1584
NC_013161:4209554:4228685422868542299741290Cyanothece sp. PCC 8802, complete genomeglucose-1-phosphate adenylyltransferase8e-1581.6
NC_008009:1264791:1285191128519112864441254Acidobacteria bacterium Ellin345, complete genomeGlucose-1-phosphate adenylyltransferase2e-1377
NC_017243:2190000:2195964219596421972501287Brachyspira intermedia PWS/A chromosome, complete genomeglucose-1-phosphate adenylyltransferase9e-1374.7
NC_014209:81643:1142151142151152611047Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,Nucleotidyl transferase4e-0962.8
NC_002689:78297:7955879558806371080Thermoplasma volcanium GSS1, complete genomeNucleoside-diphosphate-sugar pyrophosphorylase3e-0756.6