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Query: NC_008261:381297 Clostridium perfringens ATCC 13124, complete genome

Start: 381297, End: 401887, Length: 20591

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_008262:38132338132340409922777Clostridium perfringens SM101, complete genome08342BLASTN svgBLASTP svg
NC_021182:35768153576815360061123797Clostridium pasteurianum BC1, complete genome3e-67264BLASTN svgBLASTP svg
NC_014328:303063*30306337786274800Clostridium ljungdahlii ATCC 49587 chromosome, complete genome1e-63252BLASTN svgBLASTP svg
NC_010674:24352412435241245936424124Clostridium botulinum B str. Eklund 17B, complete genome9e-34153BLASTN svgBLASTP svg
NC_010723:22318342231834225453622703Clostridium botulinum E3 str. Alaska E43, complete genome3e-33151BLASTN svgBLASTP svg
NC_007681:657351*65735168076123411Methanosphaera stadtmanae DSM 3091, complete genome3e-27131BLASTN svgBLASTP svg
NC_014654:54996654996657044920484Halanaerobium sp. 'sapolanicus' chromosome, complete genome4e-1797.6BLASTN svgBLASTP svg
NC_010520:11460001146000116884922850Clostridium botulinum A3 str. Loch Maree, complete genome2e-1695.6BLASTN svgBLASTP svg
NC_013192:664408*66440868591721510Leptotrichia buccalis DSM 1135, complete genome3e-1591.7BLASTN svgBLASTP svg
NC_004193:25220002522000254434522346Oceanobacillus iheyensis HTE831, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_011661:906583*90658392459918017Dictyoglomus turgidum DSM 6724, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_014829:3822125*3822125385383631712Bacillus cellulosilyticus DSM 2522 chromosome, complete genome3e-1281.8BLASTN svgBLASTP svg
NC_013515:715009*71500975125536247Streptobacillus moniliformis DSM 12112, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_010674:426256*42625645229426039Clostridium botulinum B str. Eklund 17B, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_020291:552104*55210457702024917Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome3e-0971.9BLASTN svgBLASTP svg
NC_019908:323375*32337534639223018Brachyspira pilosicoli P43/6/78 chromosome, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_007514:1840971*1840971186546324493Chlorobium chlorochromatii CaD3, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_018604:1137797*1137797116009922303Brachyspira pilosicoli WesB complete genome6e-0763.9BLASTN svgBLASTP svg
NC_005957:48833064883306490202618721Bacillus thuringiensis serovar konkukian str. 97-27, complete6e-0763.9BLASTN svgBLASTP svg
NC_004722:50578255057825508539627572Bacillus cereus ATCC 14579, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_008261:576923*57692359692520003Clostridium perfringens ATCC 13124, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_014410:61599261599263822422233Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,2e-0661.9BLASTN svgBLASTP svg
NC_015499:1403447*1403447142823724791Thermodesulfobium narugense DSM 14796 chromosome, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_015519:26057092605709262542119713Tepidanaerobacter sp. Re1 chromosome, complete genome1e-0560BLASTN svgBLASTP svg
NC_015216:11028371102837114211939283Methanobacterium sp. AL-21 chromosome, complete genome1e-0560BLASTN svgBLASTP svg
NC_014483:4740214*4740214476409923886Paenibacillus polymyxa E681 chromosome, complete genome1e-0560BLASTN svgBLASTP svg
NC_012440:12499411249941127185421914Persephonella marina EX-H1, complete genome1e-0560BLASTN svgBLASTP svg
NC_007576:299266*29926632482425559Lactobacillus sakei subsp. sakei 23K, complete genome1e-0560BLASTN svgBLASTP svg