Pre_GI: BLASTN Hits

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Query: NC_008261:2614817 Clostridium perfringens ATCC 13124, complete genome

Start: 2614817, End: 2633417, Length: 18601

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_008262:297960*29796032314425185Clostridium perfringens SM101, complete genome2e-89337BLASTN svgBLASTP svg
NC_008262:24980002498000252144223443Clostridium perfringens SM101, complete genome8e-71276BLASTN svgBLASTP svg
NC_008262:67711*677119109923389Clostridium perfringens SM101, complete genome1e-69272BLASTN svgBLASTP svg
NC_003366:10137731013773103624122469Clostridium perfringens str. 13, complete genome2e-34155BLASTN svgBLASTP svg
NC_008262:28245032824503284819823696Clostridium perfringens SM101, complete genome2e-31145BLASTN svgBLASTP svg
NC_008261:81729581729584209724803Clostridium perfringens ATCC 13124, complete genome5e-29137BLASTN svgBLASTP svg
NC_008262:22424322242432226666224231Clostridium perfringens SM101, complete genome3e-24121BLASTN svgBLASTP svg
NC_008261:576923*57692359692520003Clostridium perfringens ATCC 13124, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_008261:2481500*2481500250521723718Clostridium perfringens ATCC 13124, complete genome1e-1075.8BLASTN svgBLASTP svg
NC_003366:22667572266757228574918993Clostridium perfringens str. 13, complete genome1e-1075.8BLASTN svgBLASTP svg
NC_008262:2150944*2150944216909918156Clostridium perfringens SM101, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_010520:72531272531274947124160Clostridium botulinum A3 str. Loch Maree, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_008261:21172072117207214023523029Clostridium perfringens ATCC 13124, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_008261:12495951249595127220022606Clostridium perfringens ATCC 13124, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_004344:622318*62231864783525518Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis,2e-0661.9BLASTN svgBLASTP svg