Pre_GI: BLASTN Hits

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Query: NC_008261:1048515 Clostridium perfringens ATCC 13124, complete genome

Start: 1048515, End: 1072892, Length: 24378

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_003366:10917661091766111615524390Clostridium perfringens str. 13, complete genome08843BLASTN svgBLASTP svg
NC_004557:2289135*2289135231328724153Clostridium tetani E88, complete genome3e-142513BLASTN svgBLASTP svg
NC_015275:44935004493500451163218133Clostridium lentocellum DSM 5427 chromosome, complete genome1e-101379BLASTN svgBLASTP svg
NC_013192:63111631119378730677Leptotrichia buccalis DSM 1135, complete genome3e-43184BLASTN svgBLASTP svg
NC_012563:23845002384500240296118462Clostridium botulinum A2 str. Kyoto, complete genome7e-35157BLASTN svgBLASTP svg
NC_010674:14965001496500152566029161Clostridium botulinum B str. Eklund 17B, complete genome4e-33151BLASTN svgBLASTP svg
NC_004557:15530001553000157059917600Clostridium tetani E88, complete genome6e-32147BLASTN svgBLASTP svg
NC_009922:86826286826289020421943Alkaliphilus oremlandii OhILAs, complete genome1e-30143BLASTN svgBLASTP svg
NC_010723:14650971465097149459929503Clostridium botulinum E3 str. Alaska E43, complete genome9e-28133BLASTN svgBLASTP svg
NC_014614:284005*28400531809934095Clostridium sticklandii, complete genome4e-27131BLASTN svgBLASTP svg
NC_020291:795500*79550085457259073Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome9e-22113BLASTN svgBLASTP svg
NC_014328:12864071286407130824221836Clostridium ljungdahlii ATCC 49587 chromosome, complete genome3e-21111BLASTN svgBLASTP svg
NC_014328:43160084316008434476228755Clostridium ljungdahlii ATCC 49587 chromosome, complete genome3e-21111BLASTN svgBLASTP svg
NC_010001:17450891745089177589430806Clostridium phytofermentans ISDg, complete genome1e-20109BLASTN svgBLASTP svg
NC_009922:25560332556033258448628454Alkaliphilus oremlandii OhILAs, complete genome1e-20109BLASTN svgBLASTP svg
NC_014376:15866491586649160872922081Clostridium saccharolyticum WM1 chromosome, complete genome2e-19105BLASTN svgBLASTP svg
NC_012563:2230403*2230403225235521953Clostridium botulinum A2 str. Kyoto, complete genome3e-1591.7BLASTN svgBLASTP svg
NC_010001:14880001488000151119123192Clostridium phytofermentans ISDg, complete genome5e-1487.7BLASTN svgBLASTP svg
NC_013517:1055854*10558541161670105817Sebaldella termitidis ATCC 33386, complete genome8e-1383.8BLASTN svgBLASTP svg
NC_018664:3009166*3009166304846639301Clostridium acidurici 9a chromosome, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_010674:18229631822963184273319771Clostridium botulinum B str. Eklund 17B, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_010723:19671061967106199111924014Clostridium botulinum E3 str. Alaska E43, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_020291:11498871149887117209922213Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome5e-0867.9BLASTN svgBLASTP svg
NC_014654:22774612277461230062123161Halanaerobium sp. 'sapolanicus' chromosome, complete genome3e-0661.9BLASTN svgBLASTP svg