Pre_GI: BLASTP Hits

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Query: NC_008261:381297:384584 Clostridium perfringens ATCC 13124, complete genome

Start: 384584, End: 385969, Length: 1386

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:381323:3870103870103883951386Clostridium perfringens SM101, complete genometldD protein truncated0894
NC_020291:552104:5668695668695682541386Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeprotein TldD1e-162573
NC_010674:426256:4445684445684459501383Clostridium botulinum B str. Eklund 17B, complete genomeTldD protein1e-161569
NC_010723:420025:4393744393744407561383Clostridium botulinum E3 str. Alaska E43, complete genomeTldD protein2e-161569
NC_016641:5808113:5811068581106858124621395Paenibacillus terrae HPL-003 chromosome, complete genomepeptidase u62 modulator of DNA gyrase8e-136484
NC_011978:1812000:1814393181439318158081416Thermotoga neapolitana DSM 4359, complete genomeTldD protein5e-128458
NC_015707:826649:8455138455138469011389Thermotoga thermarum DSM 5069 chromosome, complete genomemicrocin-processing peptidase 26e-128457
NC_013642:505518:5230925230925244801389Thermotoga naphthophila RKU-10, complete genomepeptidase U62 modulator of DNA gyrase2e-126452
NC_013457:979102:9930409930409944251386Vibrio sp. Ex25 chromosome 2, complete genomeputative TldD protein8e-105380
NC_011979:1683964:1705965170596517073471383Geobacter sp. FRC-32, complete genomepeptidase U62 modulator of DNA gyrase2e-91336
NC_010003:1242846:1247989124798912494011413Petrotoga mobilis SJ95, complete genomepeptidase U62 modulator of DNA gyrase2e-86319
NC_015222:2136657:2160899216089921623741476Nitrosomonas sp. AL212 chromosome, complete genomepeptidase U62 modulator of DNA gyrase2e-77290
NC_005071:835005:8392978392978407421446Prochlorococcus marinus str. MIT 9313, complete genomeputative modulator of DNA gyrase; TldD3e-77289
NC_008319:1167213:1184118118411811855631446Synechococcus sp. CC9311, complete genomeTldD protein3e-77289
NC_006576:456569:4739624739624754311470Synechococcus elongatus PCC 6301, complete genomeputative modulator of DNA gyrase TldD2e-74280
NC_007604:1145373:1145373114537311468421470Synechococcus elongatus PCC 7942, complete genomeputative modulator of DNA gyrase; TldD2e-74280
NC_007513:1126914:1132046113204611334581413Synechococcus sp. CC9902, complete genomeputative modulator of DNA gyrase; TldD2e-74280
NC_015942:2544407:2546427254642725478721446Acidithiobacillus ferrivorans SS3 chromosome, complete genomepeptidase U62 modulator of DNA gyrase4e-73275
NC_005070:1144777:1187537118753711889461410Synechococcus sp. WH 8102, complete genomeputative modulator of DNA gyrase; TldD4e-73275
NC_012668:160357:1872221872221886671446Vibrio cholerae MJ-1236 chromosome 1, complete sequenceTldD protein probably a protease2e-70266
NC_013416:939668:9554379554379568851449Aggregatibacter actinomycetemcomitans D11S-1, complete genomeTldD2e-68260
NC_009465:224564:2295482295482309751428Candidatus Vesicomyosocius okutanii HA, complete genomePmbA/TldD family DNA gyrase modulator1e-67257
NC_014540:2908912:2923270292327029247541485Burkholderia sp. CCGE1003 chromosome 2, complete sequencepeptidase U62 modulator of DNA gyrase2e-67257
NC_015633:2919501:2937237293723729386821446Vibrio anguillarum 775 chromosome chromosome I, complete sequenceMicrocin-processing peptidase 23e-67256
NC_013209:2782500:2799102279910228005591458Acetobacter pasteurianus IFO 3283-01, complete genomeDNA gyrase modulator TldD2e-67256
NC_017100:2782303:2798894279889428003511458Acetobacter pasteurianus IFO 3283-03, complete genomeDNA gyrase modulator TldD2e-67256
NC_017108:2779303:2796231279623127976881458Acetobacter pasteurianus IFO 3283-12, complete genomeDNA gyrase modulator TldD2e-67256
NC_017111:2779321:2796249279624927977061458Acetobacter pasteurianus IFO 3283-32, complete genomeDNA gyrase modulator TldD2e-67256
NC_017121:2781000:2797651279765127991081458Acetobacter pasteurianus IFO 3283-07, complete genomeDNA gyrase modulator TldD2e-67256
NC_017125:2782283:2798874279887428003311458Acetobacter pasteurianus IFO 3283-22, complete genomeDNA gyrase modulator TldD2e-67256
NC_017146:2782325:2798916279891628003731458Acetobacter pasteurianus IFO 3283-26, complete genomeDNA gyrase modulator TldD2e-67256
NC_017150:2689920:2706848270684827083051458Acetobacter pasteurianus IFO 3283-01-42C, complete genomeDNA gyrase modulator TldD2e-67256
NC_005955:427142:4405774405774419951419Bartonella quintana str. Toulouse, complete genometldD protein4e-66252
NC_014323:3195178:3209126320912632106311506Herbaspirillum seropedicae SmR1 chromosome, complete genomeZn-dependent protease TldD protein9e-64244
NC_016816:1545354:1549725154972515511821458Pantoea ananatis LMG 5342, complete genomeantibiotic maturation peptidase2e-58226
NC_003552:4054908:4056220405622040575751356Methanosarcina acetivorans C2A, complete genomePmbA/TldD family protein6e-44178
NC_016051:1385490:1405654140565414070151362Thermococcus sp. AM4 chromosome, complete genomeTldD/PmbA family zinc-dependent protease2e-43177
NC_006624:1952554:1951190195119019525571368Thermococcus kodakarensis KOD1, complete genomezinc-dependent protease, TldD/PmbA family7e-42172
NC_013926:1166454:1184831118483111861951365Aciduliprofundum boonei T469 chromosome, complete genomepeptidase U62 modulator of DNA gyrase3e-31136
NC_005877:864118:8785098785098798611353Picrophilus torridus DSM 9790, complete genomezinc metalloprotease5e-30132
NC_010730:1519458:1530420153042015317481329Sulfurihydrogenibium sp. YO3AOP1, complete genomepeptidase U62 modulator of DNA gyrase4e-29129
NC_015518:1638262:1643231164323116446041374Acidianus hospitalis W1 chromosome, complete genomepeptidase U62 modulator of DNA gyrase7e-28125
NC_000854:50407:6254962549639971449Aeropyrum pernix K1, complete genomeprobable peptidase1e-27124
NC_008312:1725763:1740339174033917417961458Trichodesmium erythraeum IMS101, complete genomepeptidase U62, modulator of DNA gyrase3e-26120
NC_002578:828000:8670538670538684201368Thermoplasma acidophilum DSM 1728, complete genomehypothetical protein4e-26119
NC_000961:1366000:1386469138646913878451377Pyrococcus horikoshii OT3, complete genomehypothetical protein7e-26118
NC_008261:381297:3859853859853873341350Clostridium perfringens ATCC 13124, complete genomeTldD/PmbA family protein1e-25118
NC_003413:1448377:1468976146897614703431368Pyrococcus furiosus DSM 3638, complete genomehypothetical TLDD protein2e-25117
NC_008262:381323:3884113884113897601350Clostridium perfringens SM101, complete genomeTldD/PmbA family protein4e-24113
NC_012623:1563678:1571210157121015725861377Sulfolobus islandicus Y.N.15.51 chromosome, complete genomepeptidase U62 modulator of DNA gyrase2e-22107
NC_003552:4054908:4054908405490840562271320Methanosarcina acetivorans C2A, complete genomePmbA/TldD family protein3e-22106
NC_015216:2276929:2291858229185822931621305Methanobacterium sp. AL-21 chromosome, complete genomepeptidase U62 modulator of DNA gyrase2e-21104
NC_014658:620819:6216416216416229331293Methanothermus fervidus DSM 2088 chromosome, complete genomepeptidase u62 modulator of DNA gyrase4e-21102
NC_014006:63000:8400884008853541347Sphingobium japonicum UT26S chromosome 1, complete genomeputative Zn-dependent protease PmbA1e-20101
NC_013894:543901:5456305456305469521323Thermocrinis albus DSM 14484 chromosome, complete genomepeptidase U62 modulator of DNA gyrase6e-2099
NC_003030:249648:2596482596482610751428Clostridium acetobutylicum ATCC 824, complete genomePredicted Zn-dependent protease, TLDD ortholog4e-1996.3
NC_015687:250768:2596462596462610731428Clostridium acetobutylicum DSM 1731 chromosome, complete genomeZn-dependent protease TldD4e-1996.3
NC_021182:93000:1342201342201356471428Clostridium pasteurianum BC1, complete genomeputative Zn-dependent protease-like protein1e-1894.7
NC_010723:420025:4407604407604421031344Clostridium botulinum E3 str. Alaska E43, complete genomeTldD/PmbA family protein1e-1894.7
NC_013407:1610221:1630496163049616317491254Methanocaldococcus vulcanius M7, complete genomepeptidase U62 modulator of DNA gyrase4e-1893.2
NC_010674:426256:4459544459544472971344Clostridium botulinum B str. Eklund 17B, complete genomeTldD/PmbA family protein8e-1892
NC_006677:2042387:2044485204448520458161332Gluconobacter oxydans 621H, complete genomePmbA protein8e-1892
NC_006833:902744:9174909174909188241335Wolbachia endosymbiont strain TRS of Brugia malayi, completeInactivated homolog of predicted Zn-dependent protease, PmbA1e-1791.7
NC_010003:1242846:1249401124940112507351335Petrotoga mobilis SJ95, complete genomepeptidase U62 modulator of DNA gyrase1e-1791.3
NC_006831:664000:6782586782586796251368Ehrlichia ruminantium str. Gardel, complete genomePmbA protein homolog2e-1790.9
NC_016641:5808113:5809721580972158110641344Paenibacillus terrae HPL-003 chromosome, complete genomeZn-dependent protease6e-1789.4
NC_013642:505518:5244775244775257841308Thermotoga naphthophila RKU-10, complete genomepeptidase U62 modulator of DNA gyrase1e-1688.2
NC_006832:668913:6826316826316839981368Ehrlichia ruminantium str. Welgevonden, complete genomePmbA protein homolog2e-1687.4
NC_005295:689500:7027857027857041521368Ehrlichia ruminantium str. Welgevonden, complete genomeputative PmbA protein2e-1687.4
NC_020291:552104:5682575682575696001344Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeTldD/PmbA family protein3e-1687
NC_016051:1385490:1407021140702114083281308Thermococcus sp. AM4 chromosome, complete genomeTldD/PmbA family zinc-dependent protease3e-1687
NC_007799:647514:6535166535166548621347Ehrlichia chaffeensis str. Arkansas, complete genomepmbA protein6e-1685.9
NC_015707:826649:8468988468988482231326Thermotoga thermarum DSM 5069 chromosome, complete genomepeptidase U62 modulator of DNA gyrase1e-1584.7
NC_006624:1952554:1952554195255419538431290Thermococcus kodakarensis KOD1, complete genomezinc-dependent protease, TldD/PmbA family1e-1481.6
NC_017505:841496:8620538620538633841332Neisseria meningitidis alpha710 chromosome, complete genomePmbA protein3e-1480.1
NC_009708:483253:5033115033115046511341Yersinia pseudotuberculosis IP 31758 chromosome, complete genomepeptidase PmbA5e-1479.7
NC_003143:4105754:4125645412564541269851341Yersinia pestis CO92, complete genomePutative modulator of DNA gyrase4e-1479.7
NC_009381:321577:3414693414693428091341Yersinia pestis Pestoides F chromosome, complete genomepeptidase PmbA4e-1479.7
NC_014029:4057696:4077587407758740789271341Yersinia pestis Z176003 chromosome, complete genomePutative modulator of DNA gyrase4e-1479.7
NC_017154:3997810:4017701401770140190411341Yersinia pestis D106004 chromosome, complete genomePutative modulator of DNA gyrase4e-1479.7
NC_017168:1729922:1749813174981317511531341Yersinia pestis A1122 chromosome, complete genomepeptidase PmbA4e-1479.7
NC_009655:866281:8695768695768709311356Actinobacillus succinogenes 130Z chromosome, complete genomepeptidase U62 modulator of DNA gyrase4e-1479.7
NC_007354:569321:5878725878725892061335Ehrlichia canis str. Jake, complete genomePeptidase U62, modulator of DNA gyrase4e-1479.7
NC_000961:1366000:1387847138784713891841338Pyrococcus horikoshii OT3, complete genomehypothetical protein7e-1479
NC_007973:2773427:2795043279504327964101368Ralstonia metallidurans CH34 chromosome 1, complete sequencepeptidase U62, modulator of DNA gyrase1e-1377.8
NC_003116:988000:1008771100877110101021332Neisseria meningitidis Z2491, complete genomehypothetical protein3e-1377
NC_017512:760000:7795607795607808911332Neisseria meningitidis WUE 2594, complete genomeputative PmbA-like protein3e-1377
NC_005125:637333:6511216511216524251305Gloeobacter violaceus PCC 7421, complete genomehypothetical protein3e-1377
NC_014910:1200605:1203139120313912045601422Alicycliphilus denitrificans BC chromosome, complete genomepeptidase u62 modulator of DNA gyrase4e-1376.6
NC_014122:842560:8550218550218562501230Methanocaldococcus infernus ME chromosome, complete genomepeptidase U62 modulator of DNA gyrase6e-1375.9
NC_016645:1909507:191158519115851912091507Pyrobaculum sp. 1860 chromosome, complete genometldD modulator of DNA gyrase3e-1273.6
NC_010120:788000:8082748082748096051332Neisseria meningitidis 053442, complete genomepmbA protein6e-1272.8
NC_014540:2908912:2921753292175329231111359Burkholderia sp. CCGE1003 chromosome 2, complete sequencepeptidase U62 modulator of DNA gyrase7e-1272.4
NC_012559:1663214:1664482166448216655791098Laribacter hongkongensis HLHK9, complete genomePmbA7e-1272.4
NC_003112:844000:8650308650308663611332Neisseria meningitidis MC58, complete genomepmbA protein7e-1272.4
NC_017515:1429317:1429317142931714306481332Neisseria meningitidis M04-240196 chromosome, complete genomeprotein PmbA7e-1272.4
NC_017517:867595:8880708880708894011332Neisseria meningitidis M01-240355 chromosome, complete genomeprotein PmbA7e-1272.4
NC_003413:1448377:1470356147035614716841329Pyrococcus furiosus DSM 3638, complete genomehypothetical protein2e-1171.2
NC_014323:3195178:3210664321066432120371374Herbaspirillum seropedicae SmR1 chromosome, complete genomeZn-dependent protease TLDE protein2e-1170.9
NC_011978:1812000:1813092181309218143961305Thermotoga neapolitana DSM 4359, complete genomePmbA-related protein2e-1170.9
NC_014623:4140565:4141993414199341437141722Stigmatella aurantiaca DW4/3-1 chromosome, complete genometldd/pmba family protein2e-1170.5
NC_016816:1545354:1548358154835815497071350Pantoea ananatis LMG 5342, complete genomemicrocin-processing peptidase 14e-1170.1
NC_013410:3192836:3208124320812432094521329Fibrobacter succinogenes subsp. succinogenes S85 chromosome,peptidase U62 modulator of DNA gyrase7e-1168.9
NC_004347:4211241:4231892423189242332351344Shewanella oneidensis MR-1, complete genomepmba protein1e-1068.2
NC_016948:2033311:2033311203331120348281518Mycobacterium intracellulare MOTT-64 chromosome, complete genomemodulator of DNA gyrase2e-0964.3
NC_013457:979102:9916979916979930401344Vibrio sp. Ex25 chromosome 2, complete genomepredicted Zn-dependent protease9e-0962
NC_016582:9664000:9665416966541696669421527Streptomyces bingchenggensis BCW-1 chromosome, complete genomemodulator of DNA gyrase7e-0859.3
NC_013926:1166454:1183525118352511848261302Aciduliprofundum boonei T469 chromosome, complete genomepeptidase U62 modulator of DNA gyrase7e-0755.8
NC_013771:684966:7096017096017109411341Cyanobacterium UCYN-A, complete genomepredicted Zn-dependent protease-like protein6e-0652.4