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Query: NC_008261:381297:383008 Clostridium perfringens ATCC 13124, complete genome

Start: 383008, End: 384312, Length: 1305

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:381323:3854343854343867381305Clostridium perfringens SM101, complete genomehypothetical protein0709
NC_007514:1840971:1862226186222618635331308Chlorobium chlorochromatii CaD3, complete genomehypothetical protein3e-54213
NC_010803:1436397:1462084146208414634121329Chlorobium limicola DSM 245, complete genomehypothetical protein1e-53211
NC_015930:1397524:1400464140046414015101047Lactococcus garvieae ATCC 49156, complete genomehypothetical protein2e-51203
NC_016610:383000:3963953963953977561362Tannerella forsythia ATCC 43037 chromosome, complete genomehypothetical protein4e-50199
NC_010610:795975:8254968254968267191224Lactobacillus fermentum IFO 3956, complete genomehypothetical protein2e-49196
NC_009785:1895679:191032919103291911262934Streptococcus gordonii str. Challis substr. CH1, complete genome2e-46187
NC_013192:664408:6786286786286799261299Leptotrichia buccalis DSM 1135, complete genomehypothetical protein7e-46185
NC_015638:1914000:1933227193322719347231497Lacinutrix sp. 5H-3-7-4 chromosome, complete genomehypothetical protein1e-36154
NC_009253:3317533:3325817332581733272141398Desulfotomaculum reducens MI-1 chromosome, complete genomehypothetical protein4e-2099.8
NC_014370:885937:890335890335890811477Prevotella melaninogenica ATCC 25845 chromosome chromosome I,7e-2099
NC_005071:913500:9325319325319336731143Prochlorococcus marinus str. MIT 9313, complete genomehypothetical protein1e-1895.1
NC_008820:1143500:1153106115310611542121107Prochlorococcus marinus str. MIT 9303, complete genomehypothetical protein2e-1894
NC_008319:2471341:2471341247134124724561116Synechococcus sp. CC9311, complete genomeDomain of unknown function (DUF389) family protein8e-1788.6
NC_014844:2828370:2835173283517328370591887Desulfovibrio aespoeensis Aspo-2 chromosome, complete genomehypothetical protein2e-1377
NC_011726:1456585:147482914748291475824996Cyanothece sp. PCC 8801, complete genomehypothetical protein6e-1272.4
NC_015416:1679188:1708827170882717098971071Methanosaeta concilii GP-6 chromosome, complete genomehypothetical protein5e-0962.8
NC_009635:1444461:1447192144719214481961005Methanococcus aeolicus Nankai-3 chromosome, complete genomehypothetical protein2e-0860.5
NC_013156:573037:585402585402586361960Methanocaldococcus fervens AG86, complete genomeuncharacterized hydrophobic domain protein2e-0757.8
NC_000909:597692:604259604259605221963Methanocaldococcus jannaschii DSM 2661, complete genomehypothetical protein3e-0653.5
NC_013887:1462918:147414614741461475108963Methanocaldococcus sp. FS406-22 chromosome, complete genomeuncharacterized hydrophobic domain protein4e-0653.1