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Query: NC_008261:3014373:3020946 Clostridium perfringens ATCC 13124, complete genome

Start: 3020946, End: 3021536, Length: 591

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:2788268:279830627983062798896591Clostridium perfringens str. 13, complete genomeprobable guanylate kinase3e-97353
NC_008262:2649289:266276126627612663351591Clostridium perfringens SM101, complete genomeguanylate kinase-like protein1e-96352
NC_015275:1:188201882019407588Clostridium lentocellum DSM 5427 chromosome, complete genomeguanylate kinase8e-62236
NC_015687:303810:354327354327354914588Clostridium acetobutylicum DSM 1731 chromosome, complete genomeguanylate kinase1e-58225
NC_003030:303812:354331354331354918588Clostridium acetobutylicum ATCC 824, complete genomeGuanylate kinase1e-58225
NC_014376:6296:269262692627513588Clostridium saccharolyticum WM1 chromosome, complete genomeguanylate kinase1e-48192
NC_012778:2997:238162381624418603Eubacterium eligens ATCC 27750, complete genomehypothetical protein3e-47187
NC_012785:1960500:197984919798491980481633Kosmotoga olearia TBF 19.5.1, complete genomeguanylate kinase4e-1167.8
NC_014774:1210004:125597812559781256412435Candidatus Liberibacter solanacearum CLso-ZC1 chromosome, completeguanylate kinase2e-1065.9
NC_011653:331986:336514336514337146633Thermosipho africanus TCF52B, complete genomegmk guanylate kinase5e-1064.3
NC_014532:3967463:398399839839983984630633Halomonas elongata DSM 2581, complete genomeguanylate kinase6e-1063.9
NC_007498:1491223:150660715066071507239633Pelobacter carbinolicus DSM 2380, complete genomeguanylate kinase4e-0961.2
NC_013515:550464:564756564756565301546Streptobacillus moniliformis DSM 12112, complete genomeguanylate kinase4e-0961.2
NC_017243:1229597:123296512329651233516552Brachyspira intermedia PWS/A chromosome, complete genomeguanylate kinase6e-0960.8
NC_014829:4057318:405916840591684059776609Bacillus cellulosilyticus DSM 2522 chromosome, complete genomeguanylate kinase4e-0858.2
NC_012225:787737:802842802842803393552Brachyspira hyodysenteriae WA1, complete genomeguanylate kinase4e-0858.2
NC_009616:99647:102961102961103575615Thermosipho melanesiensis BI429 chromosome, complete genomeguanylate kinase4e-0857.8
NC_014752:617987:619548619548620165618Neisseria lactamica ST-640, complete genomeguanylate kinase8e-0857
NC_016148:1175999:118312011831201183701582Thermovirga lienii DSM 17291 chromosome, complete genomeguanylate kinase1e-0756.6
NC_020419:782337:802439802439803119681Uncultured Termite group 1 bacterium phylotype Rs-D17 DNA, completeguanylate kinase1e-0756.2
NS_000191:782337:802439802439803119681Uncultured Termite group 1 bacterium phylotype Rs-D17, completeguanylate kinase1e-0756.2
NC_019970:1457794:146193214619321462543612Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeguanylate kinase2e-0755.5
NC_011979:2352961:237877223787722379380609Geobacter sp. FRC-32, complete genomeGuanylate kinase2e-0755.5
NC_021171:1354000:137461113746111375225615Bacillus sp. 1NLA3E, complete genomeguanylate kinase6e-0753.9
NC_009802:1525144:155613715561371556748612Campylobacter concisus 13826, complete genomeguanylate kinase7e-0753.9
NC_009483:3727490:373320537332053733813609Geobacter uraniireducens Rf4 chromosome, complete genomeguanylate kinase1e-0653.1
NC_004663:2509433:252512625251262525740615Bacteroides thetaiotaomicron VPI-5482, complete genomeguanylate kinase2e-0652
NC_013192:1993718:199714119971411997686546Leptotrichia buccalis DSM 1135, complete genomeguanylate kinase3e-0651.6
NC_015873:1933036:193590019359001936514615Megasphaera elsdenii DSM 20460, complete genomeguanylate kinase4e-0651.2
NC_016751:1623756:162697516269751627598624Marinitoga piezophila KA3 chromosome, complete genomeguanylate kinase6e-0650.8