Pre_GI: BLASTP Hits

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Query: NC_008261:3014373:3020288 Clostridium perfringens ATCC 13124, complete genome

Start: 3020288, End: 3020617, Length: 330

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:2788268:279764827976482797977330Clostridium perfringens str. 13, complete genomehypothetical protein1e-34145
NC_008262:2649289:266210326621032662432330Clostridium perfringens SM101, complete genomehypothetical protein8e-34142
NC_014328:85290:142585142585142914330Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein1e-26118
NC_003030:303812:354992354992355321330Clostridium acetobutylicum ATCC 824, complete genomeProtein from nitrogen regulatory protein P-II (GLNB) family, ortholog YAAQ B.subtilis8e-26115
NC_015687:303810:354988354988355317330Clostridium acetobutylicum DSM 1731 chromosome, complete genomehypothetical protein8e-26115
NC_010723:173280:212003212003212335333Clostridium botulinum E3 str. Alaska E43, complete genomeprotein from nitrogen regulatory protein P-II2e-21100
NC_010674:192951:210186210186210518333Clostridium botulinum B str. Eklund 17B, complete genomeprotein from nitrogen regulatory protein P-II2e-21100
NC_019970:35985:757057570576034330Thermoanaerobacterium thermosaccharolyticum M0795, complete genomehypothetical protein7e-2199
NC_014410:51711:892528925289581330Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,protein of unknown function DUF9707e-2199
NC_015555:49842:890278902789356330Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeprotein of unknown function DUF9706e-2096.3
NC_013171:1194500:121228112122811212610330Anaerococcus prevotii DSM 20548, complete genomeprotein of unknown function DUF9702e-1891.3
NC_010556:26567:428284282843157330Exiguobacterium sibiricum 255-15, complete genomeprotein of unknown function DUF9702e-1891.3
NC_006177:3457637:347698634769863477315330Symbiobacterium thermophilum IAM 14863, complete genomehypothetical protein3e-1890.5
NC_010321:2207364:221115722111572211486330Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completehypothetical protein3e-1890.5
NC_014219:25845:459334593346262330Bacillus selenitireducens MLS10 chromosome, complete genomeprotein of unknown function DUF9704e-1890.1
NC_016884:157894:177120177120177446327Sulfobacillus acidophilus DSM 10332 chromosome, complete genomehypothetical protein2e-1787.8
NC_013891:2643085:266348426634842663813330Listeria seeligeri serovar 1/2b str. SLCC3954, complete genomehypothetical protein2e-1787.8
NC_013768:171889:172623172623172952330Listeria monocytogenes 08-5923, complete genomehypothetical protein2e-1787.4
NC_013766:171889:172623172623172952330Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein2e-1787.4
NC_003210:2749538:276894427689442769273330Listeria monocytogenes EGD-e, complete genomehypothetical protein2e-1787.4
NC_002973:2701983:272111827211182721447330Listeria monocytogenes str. 4b F2365, complete genomehypothetical protein2e-1787.4
NC_003212:2837366:285900528590052859334330Listeria innocua Clip11262, complete genomehypothetical protein2e-1787.4
NC_014831:65408:804478044780776330Thermaerobacter marianensis DSM 12885 chromosome, complete genomeprotein of unknown function DUF9704e-1786.7
NC_017167:129988:161254161254161583330Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1hypothetical protein5e-1786.3
NC_012673:1650139:165425216542521654584333Exiguobacterium sp. AT1b, complete genomeprotein of unknown function DUF9705e-1786.3
NC_014654:391201:402708402708403067360Halanaerobium sp. 'sapolanicus' chromosome, complete genomeprotein of unknown function DUF9702e-1684.3
NC_008025:1768756:177546817754681775797330Deinococcus geothermalis DSM 11300, complete genomeprotein of unknown function DUF9704e-1683.2
NC_012121:113912:128971128971129300330Staphylococcus carnosus subsp. carnosus TM300, complete genomehypothetical protein5e-1682.8
NC_014221:687537:711536711536711865330Truepera radiovictrix DSM 17093 chromosome, complete genomeprotein of unknown function DUF9702e-1581.3
NC_004193:35698:395403954039869330Oceanobacillus iheyensis HTE831, complete genomehypothetical protein2e-1580.9