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Query: NC_008261:3014373:3018435 Clostridium perfringens ATCC 13124, complete genome

Start: 3018435, End: 3019340, Length: 906

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:2788268:279579527957952796700906Clostridium perfringens str. 13, complete genomesignal peptidase-like protein6e-161566
NC_008262:2649289:266025026602502661155906Clostridium perfringens SM101, complete genomePSP1 domain protein7e-160563
NC_010674:192951:211466211466212374909Clostridium botulinum B str. Eklund 17B, complete genomePSP1 domain protein1e-121436
NC_010723:173280:213283213283214191909Clostridium botulinum E3 str. Alaska E43, complete genomePSP1 domain protein2e-121435
NC_003030:303812:356285356285357196912Clostridium acetobutylicum ATCC 824, complete genomeSignal peptidase II (PSP1) homolog, YAAT B.subtilis ortholog1e-108392
NC_015687:303810:356281356281357192912Clostridium acetobutylicum DSM 1731 chromosome, complete genomesignal peptidase II1e-108392
NC_003869:74836:9979699796100692897Thermoanaerobacter tengcongensis MB4, complete genomehypothetical protein8e-90330
NC_010321:2207364:220883922088392209720882Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completePSP1 domain-containing protein7e-90330
NC_014654:391201:404094404094404900807Halanaerobium sp. 'sapolanicus' chromosome, complete genomePSP1 domain protein2e-87322
NC_015913:1491393:152929315292931530162870Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomePSP1 domain-containing protein6e-87320
NC_011567:1:377463774638573828Anoxybacillus flavithermus WK1, complete genomeRegulator of signaling phosphorelay (PSP1/tpl family)1e-86319
NC_014219:25845:472974729748124828Bacillus selenitireducens MLS10 chromosome, complete genomePSP1 domain protein5e-86317
NC_015275:1:214842148422380897Clostridium lentocellum DSM 5427 chromosome, complete genomePSP1 domain protein5e-86317
NC_010556:26567:441564415644986831Exiguobacterium sibiricum 255-15, complete genomePSP1 domain protein3e-85315
NC_004193:35698:413724137242196825Oceanobacillus iheyensis HTE831, complete genomesignal peptidase II2e-83309
NC_017208:1:374603746038287828Bacillus thuringiensis serovar chinensis CT-43 chromosome, completetpl protein5e-82304
NC_014171:1:379073790738734828Bacillus thuringiensis BMB171 chromosome, complete genometpl protein5e-82304
NC_012673:1650139:165240816524081653238831Exiguobacterium sp. AT1b, complete genomePSP1 domain protein7e-82304
NC_009089:4140764:414242241424224143315894Clostridium difficile 630, complete genomeputative signal peptidase II8e-82303
NC_013316:4018451:402083640208364021729894Clostridium difficile R20291, complete genomeputative signal peptidase II8e-82303
NC_006177:3457637:3474593347459334758731281Symbiobacterium thermophilum IAM 14863, complete genomeputative signal peptidase II3e-74278
NC_017167:129988:162539162539163198660Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1PSP1 domain-containing protein1e-69263
NC_008346:36176:545855458555301717Syntrophomonas wolfei subsp. wolfei str. Goettingen, completehypothetical protein2e-69262
NC_012121:113912:130401130401131207807Staphylococcus carnosus subsp. carnosus TM300, complete genomeputative homolog of PSP12e-68259
NC_013171:1194500:121069812106981211498801Anaerococcus prevotii DSM 20548, complete genomePSP1 domain protein2e-63242
NC_014632:567289:581842581842582801960Ilyobacter polytropus DSM 2926 chromosome, complete genomePSP1 domain-containing protein7e-62237
NC_015672:101878:106012106012106728717Flexistipes sinusarabici DSM 4947 chromosome, complete genomePSP1 domain-containing protein9e-57220
NC_008751:1431905:1431905143190514333681464Desulfovibrio vulgaris subsp. vulgaris DP4, complete genomePSP1 domain protein2e-53209
NC_002937:2068117:2133364213336421348271464Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough, completehypothetical protein3e-53209
NC_015389:481282:5021025021025036941593Coriobacterium glomerans PW2 chromosome, complete genomePSP1 domain protein2e-50199
NC_008578:2226778:223071322307132231546834Acidothermus cellulolyticus 11B, complete genomePSP1 domain protein6e-49194
NC_015732:30472:444564445645412957Spirochaeta caldaria DSM 7334 chromosome, complete genomePSP1 domain-containing protein2e-47189
NC_013131:9711508:971849397184939719347855Catenulispora acidiphila DSM 44928, complete genomePSP1 domain protein2e-44179
NC_018604:1489567:149226314922631493213951Brachyspira pilosicoli WesB complete genomePSP1 domain protein5e-43175
NC_008532:469888:475358475358476164807Streptococcus thermophilus LMD-9, complete genomeRegulator of signaling phosphorelay (PSP1/tpl family)8e-43174
NC_014330:2520906:252286425228642523814951Brachyspira pilosicoli 95/1000 chromosome, complete genomePsp1 protein5e-43174
NC_019908:700000:716877716877717827951Brachyspira pilosicoli P43/6/78 chromosome, complete genomePsp1 protein5e-43174
NC_006448:465656:471140471140471946807Streptococcus thermophilus LMG 18311, complete genomesignal-petidase-like protein3e-42172
NC_010003:2134878:215456721545672155403837Petrotoga mobilis SJ95, complete genomePSP1 domain protein7e-42171
NC_016148:1105669:1144171114417111454181248Thermovirga lienii DSM 17291 chromosome, complete genomePSP1 domain-containing protein5e-38158
NC_016510:1958453:1968579196857919699761398Flavobacterium columnare ATCC 49512 chromosome, complete genomehypothetical protein5e-35148
NC_018607:1251357:125364612536461254098453Brachyspira pilosicoli B2904 chromosome, complete genomePSP1 domain-containing protein7e-35147
NC_015161:1556766:155914615591461559973828Deinococcus proteolyticus MRP chromosome, complete genomePSP1 domain-containing protein3e-26119
NC_007333:3244572:326231332623133263119807Thermobifida fusca YX, complete genomesimilar to Uncharacterized protein of PSP11e-25117
NC_015557:278000:279861279861280730870Hydrogenobaculum sp. 3684 chromosome, complete genomePSP1 domain protein8e-25114
NC_020411:278000:279893279893280762870Hydrogenobaculum sp. HO, complete genomePSP1 domain protein8e-25114
NC_015587:278000:279897279897280766870Hydrogenobaculum sp. SHO chromosome, complete genomePSP1 domain protein8e-25114
NC_021064:2001786:202028220202822021040759Propionibacterium avidum 44067, complete genomehypothetical protein3e-1892.8