Pre_GI: BLASTP Hits

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Query: NC_008261:3014373:3018096 Clostridium perfringens ATCC 13124, complete genome

Start: 3018096, End: 3018266, Length: 171

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:2649289:265991126599112660120210Clostridium perfringens SM101, complete genomeferredoxin (fdxA)6e-25112
NC_003366:2788268:279545627954562795626171Clostridium perfringens str. 13, complete genomeferredoxin1e-24111
NC_015687:303810:357525357525357695171Clostridium acetobutylicum DSM 1731 chromosome, complete genomeferredoxin4e-22103
NC_003030:303812:357529357529357699171Clostridium acetobutylicum ATCC 824, complete genomeFerredoxin4e-22103
NC_010674:192951:212518212518212688171Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein4e-2096.7
NC_010723:173280:214336214336214506171Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein4e-2096.7
NC_014376:317312:335940335940336110171Clostridium saccharolyticum WM1 chromosome, complete genomeferredoxin4e-1580.1
NC_015977:3424178:342837134283713428541171Roseburia hominis A2-183 chromosome, complete genomeferredoxin3e-1477.4
NC_015437:572788:587179587179587349171Selenomonas sputigena ATCC 35185 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein7e-1372.8
NC_010001:4586000:460578746057874605954168Clostridium phytofermentans ISDg, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein1e-1272
NC_013171:1194500:121038912103891210562174Anaerococcus prevotii DSM 20548, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein1e-1272
NC_017068:638868:669587669587669757171Selenomonas ruminantium subsp. lactilytica TAM6421, completeputative ferredoxin6e-1166.2
NC_014220:2102000:211376621137662113942177Syntrophothermus lipocalidus DSM 12680 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein1e-0962
NC_015913:1491393:152901015290101529183174Candidatus Arthromitus sp. SFB-mouse-Japan, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein2e-0960.8
NC_007498:197810:209116209116209799684Pelobacter carbinolicus DSM 2380, complete genomehypothetical protein2e-0858.2
NC_014933:270000:291573291573291743171Bacteroides helcogenes P 36-108 chromosome, complete genomeferredoxin2e-0857.8
NC_014314:1148000:115283211528321153095264Dehalogenimonas lykanthroporepellens BL-DC-9 chromosome, complete4Fe-4S ferredoxin iron-sulfur-binding domain-containing protein3e-0857
NC_006347:700838:703656703656703826171Bacteroides fragilis YCH46, complete genomeferredoxin7e-0856.2
NC_014098:1670327:169521116952111695447237Bacillus tusciae DSM 2912 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein7e-0855.8
NC_009438:212476:226933226933227853921Shewanella putrefaciens CN-32 chromosome, complete genomeglycyl-radical activating family protein1e-0755.1
NC_008750:450233:464493464493465413921Shewanella sp. W3-18-1, complete genomeglycyl-radical enzyme activating protein family1e-0755.1
NC_009635:800000:822153822153822548396Methanococcus aeolicus Nankai-3 chromosome, complete genome4Fe-4S ferredoxin3e-0753.9
NC_013216:3408608:340951434095143409681168Desulfotomaculum acetoxidans DSM 771, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein4e-0753.5
NC_016584:1998000:2000204200020420013101107Desulfosporosinus orientis DSM 765 chromosome, complete genome4Fe-4S binding protein7e-0752.8
NC_015737:1976000:200251620025162003136621Clostridium sp. SY8519, complete genomehypothetical protein8e-0752.4
NC_014150:233194:236583236583236750168Brachyspira murdochii DSM 12563 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein1e-0651.6
NC_009135:620312:6268086268086280011194Methanococcus maripaludis C5, complete genome4Fe-4S ferredoxin, iron-sulfur binding domain protein2e-0651.2
NC_019978:416637:424434424434424610177Halobacteroides halobius DSM 5150, complete genome4Fe-4S protein3e-0650.4
NC_009634:714715:716933716933717331399Methanococcus vannielii SB chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein4e-0650.1
NC_015589:2049328:2073624207362420747301107Desulfotomaculum ruminis DSM 2154 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein4e-0650.1
NC_009922:315870:3255043255043272521749Alkaliphilus oremlandii OhILAs, complete genomeNADH dehydrogenase (quinone)6e-0649.7
NC_007404:387827:408901408901409152252Thiobacillus denitrificans ATCC 25259, complete genomeprobable ferredoxin protein5e-0649.7
NC_015172:775128:7958817958817971641284Syntrophobotulus glycolicus DSM 8271 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein5e-0649.7
NC_013156:226215:2355912355912367631173Methanocaldococcus fervens AG86, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein5e-0649.7
NC_015847:1418036:142115114211511421549399Methanococcus maripaludis XI chromosome, complete genomeferredoxin8e-0649.3
NC_005791:1334880:133682813368281337226399Methanococcus maripaludis S2, complete genomeferredoxin8e-0649.3
NC_018607:1134900:114914411491441149311168Brachyspira pilosicoli B2904 chromosome, complete genome4Fe-4S binding protein7e-0649.3
NC_018604:1329228:134347013434701343637168Brachyspira pilosicoli WesB complete genomeferredoxin, 4Fe-4S7e-0649.3
NC_019908:852230:854633854633854800168Brachyspira pilosicoli P43/6/78 chromosome, complete genomeferredoxin, 4Fe-4S7e-0649.3
NC_014330:2409559:242539224253922425559168Brachyspira pilosicoli 95/1000 chromosome, complete genomeferredoxin, 4Fe-4S7e-0649.3
NC_014960:3410741:341155634115563411729174Anaerolinea thermophila UNI-1, complete genomeferredoxin7e-0649.3
NC_013887:245236:276610276610277101492Methanocaldococcus sp. FS406-22 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein9e-0648.9
NC_013887:245236:275858275858276640783Methanocaldococcus sp. FS406-22 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein1e-0548.9