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Query: NC_008261:3014373:3016296 Clostridium perfringens ATCC 13124, complete genome

Start: 3016296, End: 3017978, Length: 1683

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:2788268:2793657279365727953181662Clostridium perfringens str. 13, complete genomehypothetical protein01024
NC_019978:91483:9234792347949682622Halobacteroides halobius DSM 5150, complete genomecyanophycin synthetase6e-61235
NC_008261:2743942:2747111274711127497352625Clostridium perfringens ATCC 13124, complete genomecyanophycin synthetase1e-56221
NC_005125:4557889:4559234455923445618642631Gloeobacter violaceus PCC 7421, complete genomecyanophycin synthetase4e-47189
NC_015594:579354:5971175971175998942778Sphingobium chlorophenolicum L-1 chromosome chromosome 2, completecyanophycin synthetase2e-46187
NC_019892:7734519:7734519773451977371042586Singulisphaera acidiphila DSM 18658 chromosome, complete genomecyanophycin synthetase7e-38159
NC_008781:1038158:1057546105754610601342589Polaromonas naphthalenivorans CJ2, complete genomecyanophycin synthetase7e-37155
NC_008601:1151653:1172404117240411740891686Francisella tularensis subsp. novicida U112, complete genomeMur ligase family protein3e-32140
NC_008781:1038158:1060134106013410623682235Polaromonas naphthalenivorans CJ2, complete genomecyanophycin synthetase4e-1273.6
NC_008599:29000:4859648596498851290Campylobacter fetus subsp. fetus 82-40, complete genomeUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate ligase2e-1068.2
NC_014934:2519999:2525346252534625268091464Cellulophaga algicola DSM 14237 chromosome, complete genomeudp-n-acetylmuramoyl-l-alanyl-d-glutamate--2, 6-diaminopimelateligase2e-0964.3
NC_005955:1029435:1049441104944110508921452Bartonella quintana str. Toulouse, complete genomeUDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase3e-0964.3
NC_010830:757854:7693247693247707871464Candidatus Amoebophilus asiaticus 5a2, complete genomehypothetical protein3e-0963.9
NC_019907:773944:7979767979767993041329Liberibacter crescens BT-1 chromosome, complete genomeUDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase3e-0963.9
NC_016632:230500:2380472380472395341488Serratia symbiotica str. 'Cinara cedri' chromosome, completeUDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase4e-0963.5
NC_020300:1041523:1061475106147510629261452Bartonella australis Aust/NH1, complete genomeUDP-N-acetylmuramoylalanyl-D-glutamate--2,6- diaminopimelate ligase2e-0861.6
NC_012563:1704345:1730453173045317319041452Clostridium botulinum A2 str. Kyoto, complete genomeUDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase7e-0859.3
NC_012658:1581486:1592136159213615935871452Clostridium botulinum Ba4 str. 657 chromosome, complete genomeUDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase8e-0859.3
NC_015638:591964:6080956080956095581464Lacinutrix sp. 5H-3-7-4 chromosome, complete genomeUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase1e-0758.5
NC_009465:171000:1710681710681724621395Candidatus Vesicomyosocius okutanii HA, complete genomeUDP-N-acetylmuramoylalanyl-D-glutamate--2,6- diaminopimelate ligase1e-0758.5
NC_012846:1551000:1570991157099115724421452Bartonella grahamii as4aup, complete genomeUDP-N-acetylmuramoylalanyl-D-glutamate-2,6- diaminopimelate ligase2e-0758.2
NC_015500:2197000:2213169221316922148421674Treponema brennaborense DSM 12168 chromosome, complete genomeUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase2e-0758.2
NC_007575:319119:3321643321643334651302Sulfurimonas denitrificans DSM 1251, complete genomeUDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase2e-0757.8
NC_006833:637964:6408436408436423331491Wolbachia endosymbiont strain TRS of Brugia malayi, completeUDP-N-acetylmuramyl tripeptide synthase4e-0757
NC_009615:2902871:2936500293650029379601461Parabacteroides distasonis ATCC 8503 chromosome, complete genomeUDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase7e-0756.2
NC_009515:307800:3419863419863434221437Methanobrevibacter smithii ATCC 35061, complete genomepeptide ligase2e-0654.3
NC_020291:2873000:2883810288381028852731464Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase MurE3e-0653.9