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Query: NC_008261:3014373:3015592 Clostridium perfringens ATCC 13124, complete genome

Start: 3015592, End: 3016245, Length: 654

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:2788268:279295327929532793606654Clostridium perfringens str. 13, complete genomehypothetical protein2e-121434
NC_008262:2649289:265914326591432659796654Clostridium perfringens SM101, complete genomezinc-dependent hydrolase, putative7e-119426
NC_014328:180482:184034184034184666633Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative hydrolase1e-38159
NC_011297:1296968:131464513146451315283639Dictyoglomus thermophilum H-6-12, complete genomeZn-dependent hydrolase of the metallo-beta-lactamase superfamily8e-38156
NC_015519:2526047:255363425536342554272639Tepidanaerobacter sp. Re1 chromosome, complete genomeZn-dependent hydrolase8e-38156
NC_013849:933913:956159956159956788630Ferroglobus placidus DSM 10642 chromosome, complete genomeZn-dependent hydrolase of the beta-lactamase fold-like protein7e-37153
NC_010674:192951:212846212846213484639Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein3e-36151
NC_010723:173280:214638214638215276639Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein2e-35148
NC_010520:121077:121077121077121715639Clostridium botulinum A3 str. Loch Maree, complete genomeputative zinc-dependent hydrolase5e-32137
NC_009697:120117:120117120117120755639Clostridium botulinum A str. ATCC 19397 chromosome, completezinc-dependent hydrolase6e-31134
NC_009698:120119:120119120119120757639Clostridium botulinum A str. Hall chromosome, complete genomezinc-dependent hydrolase6e-31134
NC_009699:122000:122117122117122755639Clostridium botulinum F str. Langeland chromosome, complete genomezinc-dependent hydrolase5e-31134
NC_017297:122383:122383122383123021639Clostridium botulinum F str. 230613 chromosome, complete genomeputative zinc-dependent hydrolase5e-31134
NC_010516:127000:127095127095127733639Clostridium botulinum B1 str. Okra, complete genomeputative zinc-dependent hydrolase3e-31134
NC_020291:1045058:104699210469921047636645Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeputative Zn-dependent hydrolase2e-30132
NC_015474:538544:570427570427571059633Pyrococcus sp. NA2 chromosome, complete genomehypothetical protein8e-1373.9
NC_016051:1849905:186491418649141865585672Thermococcus sp. AM4 chromosome, complete genomemetal-dependent hydrolase2e-1272.4
NC_014804:803510:809364809364809999636Thermococcus barophilus MP chromosome, complete genomehypothetical protein9e-1063.5
NC_010184:4425676:444678944467894447475687Bacillus weihenstephanensis KBAB4, complete genomebeta-lactamase domain protein1e-0963.2