Pre_GI: BLASTP Hits

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Query: NC_008261:3014373:3013376 Clostridium perfringens ATCC 13124, complete genome

Start: 3013376, End: 3014389, Length: 1014

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:2788268:2790737279073727917501014Clostridium perfringens str. 13, complete genomeputative ATP:guanido phosphotransferase0644
NC_008262:2649289:2656927265692726579401014Clostridium perfringens SM101, complete genomeATP:guanido phosphotransferase domain protein3e-180630
NC_014328:4471995:4475918447591844769581041Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative ATP:guanido phosphotransferase-like protein9e-56217
NC_003030:3324834:3329909332990933309311023Clostridium acetobutylicum ATCC 824, complete genomeputative ATP:guanido phosphotransferase7e-54211
NC_015687:3326461:3331536333153633325581023Clostridium acetobutylicum DSM 1731 chromosome, complete genomeATP:guanido phosphotransferase7e-54211
NC_017294:1457262:1493701149370114947351035Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomeATP:guanido phosphotransferase4e-53208
NC_015913:1491393:1527311152731115283451035Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomeATP:guanido phosphotransferase family protein4e-53208
NC_004557:2777291:2782133278213327831551023Clostridium tetani E88, complete genomeputative ATP:guanido phosphotransferase1e-52207
NC_011837:165913:1823981823981834351038Clostridium kluyveri NBRC 12016, complete genomeATP:guanido phosphotransferase4e-52205
NC_009706:165913:1823981823981834351038Clostridium kluyveri DSM 555 chromosome, complete genomeATP:guanido phosphotransferase4e-52205
NC_021182:4602683:4607849460784946088711023Clostridium pasteurianum BC1, complete genomearginine kinase5e-51201
NC_008593:196257:2039312039312049651035Clostridium novyi NT, complete genomeHypothetical ATP:guanido phosphotransferase2e-48193
NC_015425:198315:2086082086082096421035Clostridium botulinum BKT015925 chromosome, complete genomeATP:guanido phosphotransferase4e-47189
NC_014152:241776:2614052614052624751071Thermincola sp. JR, complete genomeATP:guanido phosphotransferase7e-47187
NC_020134:301500:3052173052173062571041Clostridium stercorarium subsp. stercorarium DSM 8532, completeputative ATP:guanido phosphotransferase6e-46184
NC_011899:86800:1031731031731042221050Halothermothrix orenii H 168, complete genomeArginine kinase7e-45181
NC_007503:2098980:2106120210612021071751056Carboxydothermus hydrogenoformans Z-2901, complete genomeputative ATP:guanido phosphotransferase3e-44179
NC_017297:3838189:3842105384210538431481044Clostridium botulinum F str. 230613 chromosome, complete genomeATP:guanido phosphotransferase domain protein4e-44179
NC_009699:3839575:3843491384349138445341044Clostridium botulinum F str. Langeland chromosome, complete genomeATP:guanido phosphotransferase4e-44179
NC_010520:3837378:3841294384129438423371044Clostridium botulinum A3 str. Loch Maree, complete genomeATP:guanido phosphotransferase domain protein4e-44178
NC_009012:2100000:2113866211386621148881023Clostridium thermocellum ATCC 27405, complete genomeATP:guanido phosphotransferase5e-44178
NC_009495:3735703:3740698374069837417411044Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeATP:guanido phosphotransferase1e-43177
NC_009697:3711692:3716687371668737177301044Clostridium botulinum A str. ATCC 19397 chromosome, completeATP:guanido phosphotransferase1e-43177
NC_009698:3609881:3613796361379636148391044Clostridium botulinum A str. Hall chromosome, complete genomeATP:guanido phosphotransferase1e-43177
NC_012563:4004709:4008624400862440096671044Clostridium botulinum A2 str. Kyoto, complete genomeATP:guanido phosphotransferase domain protein8e-44177
NC_007644:161222:1612221612221622741053Moorella thermoacetica ATCC 39073, complete genomeATP:guanido phosphotransferase8e-44177
NC_018704:81733:1081021081021091691068Amphibacillus xylanus NBRC 15112, complete genometyrosine kinase3e-43176
NC_012658:3827500:3831421383142138324641044Clostridium botulinum Ba4 str. 657 chromosome, complete genomeATP:guanido phosphotransferase4e-43175
NC_011567:75306:8990289902910231122Anoxybacillus flavithermus WK1, complete genomeTyrosine kinase McSB, modulator of heat shock repressor CtsR4e-43175
NC_014171:71963:9545995459965231065Bacillus thuringiensis BMB171 chromosome, complete genomeATP:guanido phosphotransferase3e-43175
NC_010674:192951:2147022147022157211020Clostridium botulinum B str. Eklund 17B, complete genomeputative ATP:guanido phosphotransferase9e-43174
NC_014378:131810:1452801452801463351056Acetohalobium arabaticum DSM 5501 chromosome, complete genomeATP:guanido phosphotransferase1e-42174
NC_010516:3807780:3811696381169638127391044Clostridium botulinum B1 str. Okra, complete genomeATP:guanido phosphotransferase domain protein1e-42174
NC_010723:173280:2164972164972175101014Clostridium botulinum E3 str. Alaska E43, complete genomeputative ATP:guanido phosphotransferase2e-42173
NC_017208:64500:9753097530985941065Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeATP:guanido phosphotransferase2e-42173
NC_002570:126500:1338241338241348941071Bacillus halodurans C-125, complete genomeputative ATP:guanido phosphotransferase2e-41169
NC_004193:79588:1104831104831115471065Oceanobacillus iheyensis HTE831, complete genomeputative ATP:guanido phosphotransferase1e-40167
NC_010382:4479464:4495463449546344965721110Lysinibacillus sphaericus C3-41, complete genomeputative ATP:guanido phosphotransferase2e-40166
NC_012489:1874415:1897775189777518988751101Gemmatimonas aurantiaca T-27, complete genomehypothetical protein5e-40165
NC_019970:336472:3479293479293489361008Thermoanaerobacterium thermosaccharolyticum M0795, complete genomearginine kinase9e-40164
NC_014654:2138794:2143903214390321449311029Halanaerobium sp. 'sapolanicus' chromosome, complete genomeATP:guanido phosphotransferase2e-39163
NC_012778:688621:6908266908266918571032Eubacterium eligens ATCC 27750, complete genomehypothetical protein4e-39162
NC_014219:83888:1035351035351046321098Bacillus selenitireducens MLS10 chromosome, complete genomeATP:guanido phosphotransferase4e-39162
NC_010001:4250828:4261859426185942628901032Clostridium phytofermentans ISDg, complete genomeATP:guanido phosphotransferase2e-38159
NC_013316:1:4168741687427121026Clostridium difficile R20291, complete genomeputative ATP:guanido phosphotransferase6e-38158
NC_016884:256598:2750082750082760541047Sulfobacillus acidophilus DSM 10332 chromosome, complete genomeATP:guanido phosphotransferase7e-38157
NC_015757:263938:2823482823482833941047Sulfobacillus acidophilus TPY chromosome, complete genomeATP:guanido phosphotransferase7e-38157
NC_012673:1600242:1606050160605016070931044Exiguobacterium sp. AT1b, complete genomeATP:guanido phosphotransferase9e-38157
NC_011999:2023248:2023248202324820242521005Macrococcus caseolyticus JCSC5402, complete genomeATP:guanido phosphotransferase homolog8e-36151
NC_004461:277291:2837182837182847251008Staphylococcus epidermidis ATCC 12228, complete genomeputative ATP:guanido phosphotransferase2e-35150
NC_019903:421000:4272824272824283671086Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,arginine kinase2e-35149
NC_011297:1296968:1307990130799013090601071Dictyoglomus thermophilum H-6-12, complete genomeMcsB8e-29127
NC_014761:1795304:1807082180708218081041023Oceanithermus profundus DSM 14977 chromosome, complete genomearginine kinase2e-1583.2
NC_014935:769305:7707827707827718161035Nitratifractor saLSUginis DSM 16511 chromosome, complete genomearginine kinase3e-1273.2