Pre_GI: BLASTP Hits

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Query: NC_008261:2743942:2763593 Clostridium perfringens ATCC 13124, complete genome

Start: 2763593, End: 2764717, Length: 1125

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008593:640000:6401206401206412291110Clostridium novyi NT, complete genomeethanolamine transporter (ethanolamine utilization)3e-64246
NC_015275:4493500:4494287449428744953781092Clostridium lentocellum DSM 5427 chromosome, complete genomeEthanolamine utilization protein EutH1e-51204
NC_004557:2289135:2292796229279622938871092Clostridium tetani E88, complete genomeethanolamine permease4e-51202
NC_003366:1091766:1109501110950111105981098Clostridium perfringens str. 13, complete genomeethanolamine utilization protein8e-51201
NC_008261:1048515:1066238106623810673351098Clostridium perfringens ATCC 13124, complete genomeethanolamine utilization protein EutH8e-51201
NC_013315:2059007:2075799207579920769021104Clostridium difficile CD196 chromosome, complete genomeethanolamine/propanediol transporter5e-51201
NC_017179:2067015:2083819208381920849101092Clostridium difficile BI1, complete genomeethanolamine utilization protein EutH5e-51201
NC_009633:286677:3055313055313066341104Alkaliphilus metalliredigens QYMF chromosome, complete genomeethanolamine utilisation protein, EutH2e-50199
NC_013517:1055854:1137993113799311390871095Sebaldella termitidis ATCC 33386, complete genomeEthanolamine utilisation protein EutH4e-49195
NC_014614:284005:3010953010953022221128Clostridium sticklandii, complete genomeputative ethanolamine transporter3e-47189
NC_009922:868262:8820148820148830991086Alkaliphilus oremlandii OhILAs, complete genomeEthanolamine utilisation protein EutH3e-46186
NC_014376:1586649:1603405160340516044901086Clostridium saccharolyticum WM1 chromosome, complete genomeEthanolamine utilization protein EutH4e-46185
NC_013192:63111:6827868278693751098Leptotrichia buccalis DSM 1135, complete genomeEthanolamine utilisation protein EutH8e-46184
NC_010468:1343228:1344632134463213458581227Escherichia coli ATCC 8739, complete genomeEthanolamine utilisation protein EutH8e-40164
NC_015275:566000:5829255829255840041080Clostridium lentocellum DSM 5427 chromosome, complete genomeEthanolamine utilization protein EutH3e-39162
NC_014624:1675500:1721215172121517223211107Eubacterium limosum KIST612 chromosome, complete genomeEthanolamine utilization protein EutH1e-31137
NC_016048:3983500:3987981398798139890781098Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein6e-28125
NC_018870:705900:7342887342887355261239Thermacetogenium phaeum DSM 12270 chromosome, complete genomeethanolamine utilization protein EutH2e-24113
NC_013204:2371499:2372777237277723739881212Eggerthella lenta DSM 2243, complete genomeEthanolamine utilization protein EutH2e-23110
NC_014019:3543389:3559732355973235610211290Bacillus megaterium QM B1551 chromosome, complete genomeethanolamine utilization protein EutH2e-22106
NC_004129:6240904:6240904624090462421841281Pseudomonas fluorescens Pf-5, complete genomeethanolamine utilization protein EutH1e-21104
NC_013850:2357608:2367939236793923691921254Klebsiella variicola At-22 chromosome, complete genomeEthanolamine utilisation protein EutH4e-1995.9