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Query: NC_008261:2743942:2761964 Clostridium perfringens ATCC 13124, complete genome

Start: 2761964, End: 2762407, Length: 444

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014410:8694:112481124811700453Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,FMN-binding domain protein2e-1891.3
NC_019970:8938:114921149211923432Thermoanaerobacterium thermosaccharolyticum M0795, complete genomemajor membrane immunogen, membrane-anchored lipoprotein1e-1788.6
NC_008555:2597980:261540626154062616305900Listeria welshimeri serovar 6b str. SLCC5334, complete genomeputative lipoprotein6e-1786.3
NC_015555:4478:112161121611662447Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeFMN-binding domain protein2e-1684.3
NC_016052:82358:845658456585494930Tetragenococcus halophilus NBRC 12172, complete genomehypothetical protein3e-1684
NC_017316:2637707:265656826565682657497930Enterococcus faecalis OG1RF chromosome, complete genomepheromone cAD1 lipoprotein4e-1580.1
NC_004668:3118500:313391031339103134839930Enterococcus faecalis V583, complete genomepheromone cAD1 precursor lipoprotein4e-1580.1
NC_015578:3266855:327008232700823270582501Treponema primitia ZAS-2 chromosome, complete genomemajor membrane immunogen4e-1166.6