Some Help

Query: NC_008261:2743942:2750649 Clostridium perfringens ATCC 13124, complete genome

Start: 2750649, End: 2752211, Length: 1563

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia

SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009922:315870:3361623361623377361575Alkaliphilus oremlandii OhILAs, complete genomePeptidoglycan-binding LysM8e-37155
NC_014833:2988814:3009002300900230105491548Ruminococcus albus 7 chromosome, complete genomehypothetical protein1e-1068.6
NC_014209:1910109:1910896191089619118971002Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,Peptidoglycan-binding domain 1 protein2e-0757.8
NC_018515:4474000:447697844769784477961984Desulfosporosinus meridiei DSM 13257 chromosome, complete genomecell wall hydrolase2e-0654.7
NC_017200:4240500:4245214424521442480962883Bacillus thuringiensis serovar finitimus YBT-020 chromosome,spoVID-dependent spore coat assembly factor; FtsK/SpoIIIE family protein; surface protein4e-0653.5