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Query: NC_008261:2743942:2749722 Clostridium perfringens ATCC 13124, complete genome

Start: 2749722, End: 2750558, Length: 837

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015594:579354:600779600779601582804Sphingobium chlorophenolicum L-1 chromosome chromosome 2, completecyanophycinase5e-65247
NC_019978:91483:914839148392283801Halobacteroides halobius DSM 5150, complete genomecyanophycinase6e-58224
NC_019748:1846500:186794818679481868832885Stanieria cyanosphaera PCC 7437, complete genomecyanophycinase3e-53208
NC_010175:3712456:372543237254323726241810Chloroflexus aurantiacus J-10-fl, complete genomecyanophycinase9e-44177
NC_010175:3712456:3719725371972537217822058Chloroflexus aurantiacus J-10-fl, complete genomeCyanophycinase and related exopeptidase-like protein3e-1479.3
NC_015703:5649260:5649260564926056502731014Runella slithyformis DSM 19594 chromosome, complete genomecyanophycinase-like protein6e-0858.2
NC_007948:1695500:1703402170340217045111110Polaromonas sp. JS666, complete genomepeptidase S51, dipeptidase E4e-0755.5