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Query: NC_008261:2743942:2744384 Clostridium perfringens ATCC 13124, complete genome

Start: 2744384, End: 2745364, Length: 981

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015185:140588:158144158144159127984Desulfurobacterium thermolithotrophum DSM 11699 chromosome,hypothetical protein3e-61235
NC_009465:813816:8385428385428395881047Candidatus Vesicomyosocius okutanii HA, complete genomehypothetical protein4e-60231
NC_014926:1381152:138614913861491387138990Thermovibrio ammonificans HB-1 chromosome, complete genomeprotein of unknown function DUF8144e-56218
NC_015681:1558873:157613815761381577103966Thermodesulfatator indicus DSM 15286 chromosome, complete genomehypothetical protein1e-54213
NC_006138:3355028:3355028335502833561101083Desulfotalea psychrophila LSv54, complete genomehypothetical protein9e-50197
NC_012804:1372667:139488413948841395477594Thermococcus gammatolerans EJ3, complete genomeThiamin biosynthesis protein (thiI)2e-0963.2
NC_016051:766683:786010786010786603594Thermococcus sp. AM4 chromosome, complete genomethiamine biosynthesis protein ThiI6e-0858.5
NC_015731:2400526:2416038241603824171171080Nitrosomonas sp. Is79A3 chromosome, complete genometRNA-specific 2-thiouridylase mnmA1e-0757.8
NC_003551:723901:7398167398167408621047Methanopyrus kandleri AV19, complete genomeThiamine biosynthesis ATP pyrophosphatase1e-0757.8
NC_014624:2912527:2912527291252729136061080Eubacterium limosum KIST612 chromosome, complete genometRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase1e-0757.4
NC_011969:4065460:4087446408744640885611116Bacillus cereus Q1 chromosome, complete genometRNA-specific 2-thiouridylase mnma2e-0757
NC_005957:4169610:4190467419046741915821116Bacillus thuringiensis serovar konkukian str. 97-27, completetRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase2e-0757
NC_017200:4191963:4212085421208542132001116Bacillus thuringiensis serovar finitimus YBT-020 chromosome,tRNA-specific 2-thiouridylase MnmA2e-0757
NC_011658:4171237:4192086419208641932041119Bacillus cereus AH187 chromosome, complete genometRNA-specific 2-thiouridylase MnmA2e-0757
NC_008262:1950205:1952023195202319531021080Clostridium perfringens SM101, complete genometRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase6e-0755.5
NC_014774:1057856:1075876107587610770721197Candidatus Liberibacter solanacearum CLso-ZC1 chromosome, completetRNA-specific 2-thiouridylase MnmA6e-0755.5
NC_003366:2057656:2062713206271320637651053Clostridium perfringens str. 13, complete genometRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase6e-0755.1
NC_008593:1461771:1474145147414514751971053Clostridium novyi NT, complete genometRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase6e-0755.1
NC_009485:1946000:1949469194946919506621194Bradyrhizobium sp. BTAi1 chromosome, complete genometRNA-specific 2-thiouridylase MnmA9e-0754.7
NC_011666:2109274:2109274210927421105211248Methylocella silvestris BL2, complete genometRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase1e-0654.3
NC_020210:901240:9284179284179295291113Geobacillus sp. GHH01, complete genometRNA-specific 2-thiouridylase mnmA 12e-0653.5
NC_006510:1014500:1035332103533210364441113Geobacillus kaustophilus HTA426, complete genometRNA (5-methylaminomethyl-2-thiouridylate)- methyltransferase2e-0653.5
NC_012804:1372667:1392945139294513940871143Thermococcus gammatolerans EJ3, complete genomeThiamine biosynthesis protein (ThiI)2e-0653.5
NC_004757:1021355:1049051104905110501391089Nitrosomonas europaea ATCC 19718, complete genometrmU; tRNA 5-methylaminomethyl-2-thiouridylate-methyltransferase protein2e-0653.5
NC_016051:766683:7842677842677854091143Thermococcus sp. AM4 chromosome, complete genomethiamine biosynthesis protein ThiI-like protein3e-0652.8
NC_015555:863173:8758378758378769461110Thermoanaerobacterium xylanolyticum LX-11 chromosome, completetRNA-specific 2-thiouridylase mnmA4e-0652.8
NC_008435:1131242:1175599117559911768581260Rhodopseudomonas palustris BisA53, complete genometRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase4e-0652.4
NC_014377:1089894:1105508110550811066021095Thermosediminibacter oceani DSM 16646 chromosome, complete genometRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase4e-0652.4
NC_000909:1615927:161966916196691620451783Methanocaldococcus jannaschii DSM 2661, complete genomehypothetical protein4e-0652.4