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Query: NC_008261:2743942:2743942 Clostridium perfringens ATCC 13124, complete genome

Start: 2743942, End: 2744361, Length: 420

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_018664:159291:161910161910162323414Clostridium acidurici 9a chromosome, complete genomecalycin-like domain-containing protein2e-1994.4
NC_014654:422013:441032441032441460429Halanaerobium sp. 'sapolanicus' chromosome, complete genomeDomain of unknown function DUF19343e-1063.9
NC_014376:597000:597894597894598340447Clostridium saccharolyticum WM1 chromosome, complete genomeDomain of unknown function DUF19342e-0961.2
NC_011899:1926000:193118719311871931615429Halothermothrix orenii H 168, complete genomehypothetical protein3e-0753.9
NC_009725:3559257:356224835622483562676429Bacillus amyloliquefaciens FZB42, complete genomeYwiB8e-0752.4
NC_020410:3547345:355638535563853556813429Bacillus amyloliquefaciens subsp. plantarum UCMB5036 completeUncharacterized beta-barrel protein ywiB8e-0752.4
NC_019842:3594409:359740035974003597828429Bacillus amyloliquefaciens subsp. plantarum AS43.3 chromosome,hypothetical protein8e-0752.4
NC_014392:1935130:194639019463901946842453Caldicellulosiruptor obsidiansis OB47 chromosome, complete genomehypothetical protein9e-0752.4