Pre_GI: BLASTP Hits

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Query: NC_008261:225425:252899 Clostridium perfringens ATCC 13124, complete genome

Start: 252899, End: 256417, Length: 3519

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:255480:2835142835142870413528Clostridium perfringens str. 13, complete genomeprobable exonuclease01638
NC_008262:227354:2553562553562588743519Clostridium perfringens SM101, complete genomeexonuclease SbcC01634
NC_014328:2203437:2207647220764722111413495Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative nuclease sbcCD subunit C1e-89332
NC_009617:1165539:1172409117240911759003492Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeSMC domain-containing protein4e-88327
NC_015425:405058:4139804139804175103531Clostridium botulinum BKT015925 chromosome, complete genomeexonuclease3e-65251
NC_012658:545840:5635745635745671043531Clostridium botulinum Ba4 str. 657 chromosome, complete genomeexonuclease SbcCD subunit C4e-59230
NC_010516:583870:5876355876355911653531Clostridium botulinum B1 str. Okra, complete genomeexonuclease SbcC4e-59230
NC_009699:564455:5709295709295744593531Clostridium botulinum F str. Langeland chromosome, complete genomeexonuclease SbcC9e-59229
NC_017297:564727:5712015712015727811581Clostridium botulinum F str. 230613 chromosome, complete genome2e-56221
NC_016641:5528826:5535086553508655384843399Paenibacillus terrae HPL-003 chromosome, complete genomeDNA repair ATPase2e-52208
NC_014483:3498395:3502055350205535054503396Paenibacillus polymyxa E681 chromosome, complete genomeATPase involved in DNA repair2e-52208
NC_014622:3819495:3822728382272838261173390Paenibacillus polymyxa SC2 chromosome, complete genomesmc domain protein7e-51203
NC_014633:339181:3420573420573450743018Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceSMC domain-containing protein1e-45186
NC_019904:2010999:2007979200797920110023024Echinicola vietnamensis DSM 17526 chromosome, complete genomeDNA repair ATPase1e-32143
NC_013730:7118798:7136893713689371399823090Spirosoma linguale DSM 74, complete genomeATPase-like protein involved in DNA repair3e-26121
NC_004460:81687:8168781687847523066Vibrio vulnificus CMCP6 chromosome II, complete sequenceATPase involved in DNA repair1e-21106
NC_014966:638355:6383556383556414203066Vibrio vulnificus MO6-24/O chromosome II, complete sequenceexonuclease SbcC2e-21105
NC_016630:1610723:1607605160760516107363132Filifactor alocis ATCC 35896 chromosome, complete genomeexonuclease SbcC7e-21103
NC_005140:660305:6603056603056633703066Vibrio vulnificus YJ016 chromosome II, complete sequenceputative exonuclease SbcC6e-21103
NC_013520:1559000:1577803157780315808863084Veillonella parvula DSM 2008, complete genomeATPase involved in DNA repair-like protein7e-20100
NC_013715:767722:7862597862597895523294Rothia mucilaginosa DY-18, complete genomeATPase involved in DNA repair1e-19100
NC_015500:2112975:2146324214632421494163093Treponema brennaborense DSM 12168 chromosome, complete genomeexonuclease1e-1999.4
NC_008740:637870:6514396514396547143276Marinobacter aquaeolei VT8, complete genomeSMC domain protein3e-1998.6
NC_014972:3688000:3712226371222637158883663Desulfobulbus propionicus DSM 2032 chromosome, complete genomeSMC domain-containing protein4e-1998.2
NC_016002:1975000:1976360197636019797823423Pseudogulbenkiania sp. NH8B, complete genomenuclease SbcCD subunit C4e-1997.8
NC_003997:2175843:2194319219431921974083090Bacillus anthracis str. Ames, complete genomeexonuclease, putative6e-1997.4
NC_005945:2175871:2194425219442521975143090Bacillus anthracis str. Sterne, complete genomeexonuclease, putative6e-1997.4
NC_007530:2175967:2194443219444321975323090Bacillus anthracis str. 'Ames Ancestor', complete genomeexonuclease, putative6e-1997.4
NC_012659:2175867:2194343219434321974323090Bacillus anthracis str. A0248, complete genomeputative exonuclease6e-1997.4
NC_011773:2239753:2258273225827322613623090Bacillus cereus AH820 chromosome, complete genomeputative exonuclease5e-1997.4
NC_005957:2196000:2213974221397422170633090Bacillus thuringiensis serovar konkukian str. 97-27, completeexonuclease SbcC5e-1997.4
NC_012472:2240000:2258080225808022611693090Bacillus cereus 03BB102, complete genomeputative exonuclease5e-1997.4
NC_014335:2151404:2170610217061021736993090Bacillus cereus biovar anthracis str. CI chromosome, completeexonuclease SbcC5e-1997.4
NC_011658:2275864:2293805229380522968943090Bacillus cereus AH187 chromosome, complete genomeputative exonuclease7e-1997.1
NC_011725:2206000:2224750222475022278393090Bacillus cereus B4264 chromosome, complete genomeexonuclease1e-1896.7
NC_014171:2177353:2196894219689421999833090Bacillus thuringiensis BMB171 chromosome, complete genomeexonuclease SbcC1e-1896.7
NC_011772:2166000:2184317218431721874063090Bacillus cereus G9842, complete genomeputative exonuclease1e-1896.3
NC_015497:1058980:1066367106636710700533687Glaciecola agarilytica 4H-3-7+YE-5 chromosome, complete genomeSMC domain protein2e-1895.9
NC_007484:755058:7563267563267596013276Nitrosococcus oceani ATCC 19707, complete genomeATP-dependent dsDNA exonuclease (SbcC)4e-1791.3
NC_017955:4746441:4748762474876247501591398Modestobacter marinus, complete genomehypothetical protein8e-1790.5
NC_015276:2552484:2552484255248425562843801Marinomonas mediterranea MMB-1 chromosome, complete genomeSMC domain protein1e-1689.7
NC_017328:335160:3599823599823631253144Shigella flexneri 2002017 chromosome, complete genomeATP-dependent dsDNA exonuclease4e-1688.2
NC_015510:8069440:8088951808895180925983648Haliscomenobacter hydrossis DSM 1100 chromosome, complete genomeSMC domain-containing protein7e-1687
NC_015975:441580:4427044427044458083105Lactobacillus ruminis ATCC 27782 chromosome, complete genomeExonuclease SbcCD subunit C8e-1687
NC_015437:767572:7702657702657733393075Selenomonas sputigena ATCC 35185 chromosome, complete genomeSMC domain protein9e-1686.7
NC_015578:3561838:3580249358024935834313183Treponema primitia ZAS-2 chromosome, complete genomenuclease sbcCD subunit C1e-1586.3
NC_015733:1793399:1793399179339917970433645Pseudomonas putida S16 chromosome, complete genomeSMC domain-containing protein2e-1585.9
NC_016745:123772:1392501392501426603411Oceanimonas sp. GK1 chromosome, complete genomeSMC domain-containing protein1e-1483.2
NC_014554:1339566:1347871134787113510563186Lactobacillus plantarum subsp. plantarum ST-III chromosome,exonuclease SbcC2e-1482.8
NC_016830:4295831:4297092429709243007333642Pseudomonas fluorescens F113 chromosome, complete genomeprotein SbcC2e-1482.4
NC_020054:2033982:2036050203605020391333084Fibrella aestuarina BUZ 2 drat genomeNuclease sbcCD subunit C4e-1481.3
NC_017955:4746441:4746441474644147487652325Modestobacter marinus, complete genomehypothetical protein5e-1481.3
NC_016776:3485688:3494865349486534978282964Bacteroides fragilis 638R, complete genomeputative exonuclease6e-1480.9
NC_003228:3455405:3463154346315434661172964Bacteroides fragilis NCTC 9343, complete genomeputative exonuclease6e-1480.9
NC_021171:1661923:1670095167009516732323138Bacillus sp. 1NLA3E, complete genomeSbcC family exonuclease2e-1379.3
NC_009663:738846:7433417433417457072367Sulfurovum sp. NBC37-1, complete genomeDNA double-strand break repair protein2e-1379
NC_016111:409852:4307414307414337493009Streptomyces cattleya NRRL 8057, complete genomeATP-dependent dsDNA exonuclease1e-1276.3
NC_010612:4400260:4417219441721944202273009Mycobacterium marinum M, complete genomechromosome partition ATPase protein2e-1275.9
NC_014762:1204584:1218433121843312207902358Sulfuricurvum kujiense DSM 16994 chromosome, complete genomesmc domain protein3e-1275.1
NC_013855:558831:5597075597075634683762Azospirillum sp. B510 plasmid pAB510a, complete sequenceexonuclease3e-1275.1
NC_015930:821342:8269308269308300673138Lactococcus garvieae ATCC 49156, complete genomeexonuclease SbcC1e-1173.6
NC_009615:2039964:2044986204498620479672982Parabacteroides distasonis ATCC 8503 chromosome, complete genomeATP-dependent exonuclease sbcC8e-1273.6
NC_017187:1580988:1580988158098815833572370Arcobacter butzleri ED-1, complete genomechromosome segregation protein7e-1067.4
NC_017187:1564403:1580988158098815833572370Arcobacter butzleri ED-1, complete genomechromosome segregation protein7e-1067.4
NC_015172:1255956:1260972126097212641393168Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeSMC domain-containing protein8e-1067
NC_015931:1443447:1449031144903114517572727Pyrolobus fumarii 1A, complete genomeSMC domain containing protein5e-0964.3
NC_014160:748743:7794917794917823042814Thermosphaera aggregans DSM 11486 chromosome, complete genomeSMC domain-containing protein2e-0759.3
NC_008698:471564:4782444782444805982355Thermofilum pendens Hrk 5, complete genomeSMC domain protein2e-0758.9
NC_014314:755166:7738247738247764152592Dehalogenimonas lykanthroporepellens BL-DC-9 chromosome, completeSMC domain-containing protein1e-0656.6
NC_003413:1107965:1114820111482011174682649Pyrococcus furiosus DSM 3638, complete genomechromosome segregation protein2e-0655.8