Pre_GI: BLASTP Hits

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Query: NC_008261:225425:250644 Clostridium perfringens ATCC 13124, complete genome

Start: 250644, End: 251288, Length: 645

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:227354:253101253101253745645Clostridium perfringens SM101, complete genomeheme oxygenase 25e-120429
NC_003366:255480:281268281268281912645Clostridium perfringens str. 13, complete genomeprobable heme oxygenase2e-117421
NC_004113:350059:363157363157363876720Thermosynechococcus elongatus BP-1, complete genomeheme oxygenase 16e-34144
NC_011884:2921618:292417229241722924891720Cyanothece sp. PCC 7425, complete genomeHeme oxygenase1e-29129
NC_011126:1345984:134937013493701350062693Hydrogenobaculum sp. Y04AAS1, complete genomeHeme oxygenase2e-25115
NC_015557:1333158:133940213394021340094693Hydrogenobaculum sp. 3684 chromosome, complete genomeHeme oxygenase1e-25115
NC_020411:1333352:133959613395961340288693Hydrogenobaculum sp. HO, complete genomeHeme oxygenase1e-25115
NC_013947:4917711:492143049214304922119690Stackebrandtia nassauensis DSM 44728 chromosome, complete genomeHeme oxygenase2e-2099
NC_007164:380000:389709389709390383675Corynebacterium jeikeium K411, complete genomehypothetical protein4e-2097.8
NC_013715:2001862:200544820054482006110663Rothia mucilaginosa DY-18, complete genomeheme oxygenase3e-1995.1
NC_020302:85821:113337113337114005669Corynebacterium halotolerans YIM 70093 = DSM 44683, completeHeme oxygenase9e-1993.6