Pre_GI: BLASTP Hits

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Query: NC_008261:225425:243192 Clostridium perfringens ATCC 13124, complete genome

Start: 243192, End: 244250, Length: 1059

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:255480:2738152738152748731059Clostridium perfringens str. 13, complete genomehypothetical protein0638
NC_008262:227354:2470742470742481711098Clostridium perfringens SM101, complete genomeAcyltransferase family, putative1e-176619
NC_007907:2830574:2839633283963328406821050Desulfitobacterium hafniense Y51, complete genomehypothetical protein2e-1997.1
NC_014033:1691822:169937016993701700338969Prevotella ruminicola 23 chromosome, complete genomeacyltransferase family protein7e-1168.6
NC_017060:59500:712157121572180966Rahnella aquatilis HX2 plasmid PRA1, complete sequenceacyltransferase 32e-1066.6
NC_002678:763808:7813347813347833522019Mesorhizobium loti MAFF303099, complete genomeprobable glycosyltransferase8e-1065.1
NC_002678:3701500:3713486371348637152161731Mesorhizobium loti MAFF303099, complete genomeglycosyltransferase, contains similarity to NolL7e-0962
NC_014033:1633493:165176916517691652767999Prevotella ruminicola 23 chromosome, complete genomeacyltransferase family protein2e-0860.1
NC_014833:3444550:3448271344827134493741104Ruminococcus albus 7 chromosome, complete genomeacyltransferase 32e-0757.4
NC_010067:2529750:2561261256126125622771017Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein3e-0756.2
NC_009436:1466580:147231614723161473314999Enterobacter sp. 638, complete genomeacyltransferase6e-0755.5
NC_012522:5987644:600449560044956005472978Rhodococcus opacus B4, complete genomeputative acyltransferase4e-0652.4
NC_017271:2906000:2913747291374729148021056Xanthomonas campestris pv. raphani 756C chromosome, completeexopolysaccharide xanthan biosynthesis acetyltransferase GumF8e-0651.6
NC_004567:1089231:1113822111382211149011080Lactobacillus plantarum WCFS1, complete genomeO-acetyltransferase1e-0551.2