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Query: NC_008261:225425:227239 Clostridium perfringens ATCC 13124, complete genome

Start: 227239, End: 228102, Length: 864

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:227354:229532229532230395864Clostridium perfringens SM101, complete genome5'-nucleotidase, lipoprotein e(P4) family4e-157553
NC_003366:255480:257764257764258627864Clostridium perfringens str. 13, complete genomeprobable acid phosphatase4e-156550
NC_015425:718384:729332729332730138807Clostridium botulinum BKT015925 chromosome, complete genome5'-nucleotidase5e-77287
NC_020291:1810527:182642818264281827258831Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome5'-nucleotidase, lipoprotein e(P4) family1e-51203
NC_014562:2871765:289365728936572894469813Pantoea vagans C9-1 chromosome, complete genomeacid phosphatase6e-47187
NC_015559:2434000:244875424487542449581828Marinomonas posidonica IVIA-Po-181 chromosome, complete genome5'-nucleotidase, lipoprotein e(P4) family2e-46185
NC_016513:54802:775597755978371813Aggregatibacter actinomycetemcomitans ANH9381 chromosome, complete5'-nucleotidase8e-45180
NC_012880:1765920:178118717811871781996810Dickeya dadantii Ech703, complete genome5'-nucleotidase, lipoprotein e(P4) family1e-43177
NC_004461:205068:222073222073222948876Staphylococcus epidermidis ATCC 12228, complete genomeouter membrane protein precursor7e-43174
NC_015634:652000:677257677257678042786Bacillus coagulans 2-6 chromosome, complete genome5'-nucleotidase, lipoprotein e(P4) family2e-40166
NC_010803:2444120:246366224636622464480819Chlorobium limicola DSM 245, complete genomeacid phosphatase (Class B)3e-27122