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Query: NC_008261:1:4666 Clostridium perfringens ATCC 13124, complete genome

Start: 4666, End: 4926, Length: 261

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:1:466546654925261Clostridium perfringens str. 13, complete genomehypothetical protein7e-44175
NC_008262:1:449044904750261Clostridium perfringens SM101, complete genomehypothetical protein7e-44175
NC_010674:1:432343234583261Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein8e-38155
NC_010723:1:427542754535261Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein8e-38155
NC_012563:1:427942794542264Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein7e-37152
NC_010520:1:412741274390264Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein7e-37152
NC_010516:1:415041504413264Clostridium botulinum B1 str. Okra, complete genomehypothetical protein7e-37152
NC_009495:1:412241224385264Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein7e-37152
NC_009697:1:412241224385264Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein7e-37152
NC_009698:1:412241224385264Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein7e-37152
NC_009699:1:412341234386264Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein7e-37152
NC_012658:1:428642864549264Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein7e-37152
NC_017297:1:412341234386264Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein7e-37152
NC_020291:1:423042304490261Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein1e-36151
NC_008593:2527064:254311225431122543381270Clostridium novyi NT, complete genomehypothetical protein4e-34143
NC_015687:1:448944894821333Clostridium acetobutylicum DSM 1731 chromosome, complete genomehypothetical protein3e-34143
NC_003030:1:448944894821333Clostridium acetobutylicum ATCC 824, complete genomeUncharacterized small conserved protein, ortholog of YAAB B.subtilis3e-34143
NC_009706:1:414741474410264Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein4e-33140
NC_011837:1:414141414410270Clostridium kluyveri NBRC 12016, complete genomehypothetical protein3e-33140
NC_021182:1:455845584821264Clostridium pasteurianum BC1, complete genomehypothetical protein3e-33140
NC_015425:2752482:276855427685542768823270Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein2e-33140
NC_014328:1:423642364499264Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein7e-32135
NC_014393:1:455645564819264Clostridium cellulovorans 743B chromosome, complete genomehypothetical protein7e-32135
NC_009922:1:442244224757336Alkaliphilus oremlandii OhILAs, complete genomeconserved hypothetical protein7e-1372.8
NC_010718:1:521852185517300Natranaerobius thermophilus JW/NM-WN-LF, complete genomehypothetical protein2e-1168.2
NC_021184:1:447544754708234Desulfotomaculum gibsoniae DSM 7213, complete genomeprotein of unknown function (DUF370)9e-1165.5
NC_018664:1:428942894576288Clostridium acidurici 9a chromosome, complete genomehypothetical protein3e-1063.9
NC_015565:2879603:406040604320261Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completehypothetical protein5e-1062.8
NC_014152:1:414141414395255Thermincola sp. JR, complete genomehypothetical protein2e-0961.2
NC_014098:3372000:444444444701258Bacillus tusciae DSM 2912 chromosome, complete genomehypothetical protein2e-0960.8
NC_014378:525717:532553255582258Acetohalobium arabaticum DSM 5501 chromosome, complete genomehypothetical protein4e-0960.1
NC_014378:4428:532553255582258Acetohalobium arabaticum DSM 5501 chromosome, complete genomehypothetical protein4e-0960.1
NC_015519:2739347:465446544920267Tepidanaerobacter sp. Re1 chromosome, complete genomehypothetical protein2e-0857.8
NC_014654:1:424142414501261Halanaerobium sp. 'sapolanicus' chromosome, complete genomehypothetical protein2e-0857.8
NC_013895:66641:939649396494242279Clostridiales genomosp. BVAB3 str. UPII9-5 chromosome, completehypothetical protein3e-0753.9
NC_007644:3229:449444944745252Moorella thermoacetica ATCC 39073, complete genomeYaaB5e-0649.7