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Query: NC_008261:1:3305 Clostridium perfringens ATCC 13124, complete genome

Start: 3305, End: 3511, Length: 207

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:1:330433043510207Clostridium perfringens str. 13, complete genomehypothetical protein9e-33138
NC_008262:1:312931293335207Clostridium perfringens SM101, complete genomeS4 domain protein9e-33138
NC_003030:1:319531953401207Clostridium acetobutylicum ATCC 824, complete genomeSmall conserved protein, ortholog of YAAA B.subtilis7e-2199
NC_015687:1:319531953401207Clostridium acetobutylicum DSM 1731 chromosome, complete genomehypothetical protein7e-2199
NC_010516:1:276027602966207Clostridium botulinum B1 str. Okra, complete genomeS4 domain protein1e-2098.6
NC_012563:1:287928793085207Clostridium botulinum A2 str. Kyoto, complete genomeS4 domain protein1e-2098.6
NC_009495:1:273227322938207Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeS4 domain-containing protein1e-2098.6
NC_009697:1:273227322938207Clostridium botulinum A str. ATCC 19397 chromosome, completeS4 domain-containing protein1e-2098.6
NC_009698:1:273227322938207Clostridium botulinum A str. Hall chromosome, complete genomeS4 domain-containing protein1e-2098.6
NC_009699:1:272327232929207Clostridium botulinum F str. Langeland chromosome, complete genomeS4 domain-containing protein1e-2098.6
NC_017297:1:272327232929207Clostridium botulinum F str. 230613 chromosome, complete genomeS4 domain-containing protein1e-2098.6
NC_012658:1:289628963102207Clostridium botulinum Ba4 str. 657 chromosome, complete genomeS4 domain-containing protein5e-2096.3
NC_010520:1:273727372943207Clostridium botulinum A3 str. Loch Maree, complete genomeS4 domain protein7e-2095.9
NC_014328:1:284128413047207Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein3e-1994
NC_015425:2752482:276998027699802770186207Clostridium botulinum BKT015925 chromosome, complete genomeS4 domain-containing protein5e-1993.2
NC_008593:2527064:254454325445432544749207Clostridium novyi NT, complete genomeS4 domain protein6e-1992.8
NC_021182:1:317031703376207Clostridium pasteurianum BC1, complete genomehypothetical protein6e-1889.4
NC_010674:1:294529453151207Clostridium botulinum B str. Eklund 17B, complete genomeS4 domain protein YaaA3e-1787.4
NC_010723:1:289728973103207Clostridium botulinum E3 str. Alaska E43, complete genomeS4 domain protein YaaA3e-1787.4
NC_009706:1:274627462952207Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein4e-1786.7
NC_011837:1:274627462952207Clostridium kluyveri NBRC 12016, complete genomehypothetical protein4e-1786.7
NC_015275:1:282728273033207Clostridium lentocellum DSM 5427 chromosome, complete genomeRNA-binding S4 domain protein3e-1683.6
NC_014393:1:299529953252258Clostridium cellulovorans 743B chromosome, complete genomeS4 domain-containing protein YaaA9e-1682
NC_020291:1:285528553061207Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeRNA-binding S4 domain-containing protein1e-1582
NC_015519:2739347:285428543075222Tepidanaerobacter sp. Re1 chromosome, complete genomeRNA-binding S4 domain-containing protein1e-1272
NC_013192:2434664:273227322959228Leptotrichia buccalis DSM 1135, complete genomeS4 domain protein YaaA9e-1372
NC_014654:1:288928893107219Halanaerobium sp. 'sapolanicus' chromosome, complete genomeRNA-binding S4 domain protein6e-1269.7
NC_014973:4630132:464848946484894648686198Geobacter sp. M18 chromosome, complete genomeRNA-binding S4 domain-containing protein1e-1168.9
NC_018664:1:285728573069213Clostridium acidurici 9a chromosome, complete genomeRNA-binding S4 domain-containing protein3e-1167.4
NC_014378:525717:307530753284210Acetohalobium arabaticum DSM 5501 chromosome, complete genomeRNA-binding S4 domain protein6e-1166.2
NC_011297:1357947:137723113772311377446216Dictyoglomus thermophilum H-6-12, complete genomehypothetical protein7e-1165.9
NC_006177:3549467:271827182945228Symbiobacterium thermophilum IAM 14863, complete genomehypothetical protein5e-1063.2
NC_010814:155834:164012164012164230219Geobacter lovleyi SZ, complete genomeS4 domain protein YaaA8e-1062.4
NC_014152:1:277527752999225Thermincola sp. JR, complete genomeRNA-binding S4 domain protein1e-0962
NC_009922:1:284628463061216Alkaliphilus oremlandii OhILAs, complete genomeRNA-binding S4 domain protein3e-0960.5
NC_010001:1:309930993314216Clostridium phytofermentans ISDg, complete genomeRNA-binding S4 domain protein1e-0858.2
NC_009089:1:280528053011207Clostridium difficile 630, complete genomeputative RNA-binding mediating protein2e-0857.8
NC_018665:1:327232723493222Exiguobacterium antarcticum B7 chromosome, complete genomeS4 domain protein YaaA3e-0857.4
NC_008319:1081614:108923710892371089461225Synechococcus sp. CC9311, complete genomeS4 domain protein5e-0856.6
NC_012673:1679744:169743216974321697647216Exiguobacterium sp. AT1b, complete genomeS4 domain protein YaaA8e-0855.8
NC_015565:2879603:272527252934210Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completeRNA-binding S4 domain-containing protein9e-0855.5
NC_011567:1:313631363348213Anoxybacillus flavithermus WK1, complete genomeS4-like RNA binding protein2e-0754.7
NC_015690:8645500:274927492964216Paenibacillus mucilaginosus KNP414 chromosome, complete genomeYaaA2e-0754.7
NC_017208:1:307530753287213Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein3e-0753.9
NC_014171:1:307530753287213Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein4e-0753.5
NC_001263:1378605:139623013962301396544315Deinococcus radiodurans R1 chromosome 1, complete sequencehypothetical protein5e-0753.1
NC_007929:1805000:308830883309222Lactobacillus salivarius subsp. salivarius UCC118, complete genomehypothetical protein5e-0753.1
NC_011146:482440:490129490129490326198Geobacter bemidjiensis Bem, complete genomeRNA-binding S4 domain protein1e-0651.6
NC_010718:1:291229123133222Natranaerobius thermophilus JW/NM-WN-LF, complete genomeS4-like RNA binding protein2e-0651.2
NC_017317:134671:143442143442143732291Corynebacterium ulcerans 809 chromosome, complete genomehypothetical protein8e-0649.3