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Query: NC_008261:1:15422 Clostridium perfringens ATCC 13124, complete genome

Start: 15422, End: 15925, Length: 504

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:1:156331563315926294Clostridium perfringens str. 13, complete genomehypothetical protein2e-49194
NC_003366:1:154221542215625204Clostridium perfringens str. 13, complete genomehypothetical protein7e-29126
NC_014393:1:151741517415683510Clostridium cellulovorans 743B chromosome, complete genomemetal-dependent phosphohydrolase HD sub domain2e-25115
NC_004557:32094:376413764138144504Clostridium tetani E88, complete genomehypothetical protein4e-22103
NC_008593:2527064:253269025326902533199510Clostridium novyi NT, complete genomehypothetical protein5e-21100
NC_015425:2752482:275809827580982758562465Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein3e-21100
NC_014328:1:145991459915102504Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein3e-1787.8
NC_009698:1:144421444214894453Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein5e-1683.6
NC_009697:1:144421444214894453Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein5e-1683.6
NC_009495:1:144271442714879453Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein5e-1683.6
NC_010516:1:144711447114923453Clostridium botulinum B1 str. Okra, complete genomehypothetical protein8e-1683.2
NC_017297:1:144181441814870453Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein8e-1683.2
NC_012563:1:146241462415076453Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein7e-1683.2
NC_010520:1:144511445114873423Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein1e-1582.4
NC_009699:1:143821438214804423Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein4e-1580.5
NC_010723:1:146331463315136504Clostridium botulinum E3 str. Alaska E43, complete genomeputative HD domain1e-1479.3
NC_010674:1:146791467915182504Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein2e-1478.2
NC_009706:1:148251482515238414Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein4e-1477.4
NC_011837:1:148251482515238414Clostridium kluyveri NBRC 12016, complete genomehypothetical protein4e-1477.4
NC_012658:1:145621456215014453Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein1e-1272.4
NC_020291:1:146841468415193510Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeputative domain HDIG-containing protein2e-1271.6
NC_015687:1:147351473515211477Clostridium acetobutylicum DSM 1731 chromosome, complete genomeHD superfamily hydrolase5e-1270.5
NC_003030:1:147351473515211477Clostridium acetobutylicum ATCC 824, complete genomePredicted HD superfamily hydrolase5e-1270.5