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Query: NC_008261:1332864:1340908 Clostridium perfringens ATCC 13124, complete genome

Start: 1340908, End: 1341333, Length: 426

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:1122654:113004411300441130469426Clostridium perfringens str. 13, complete genomecoenzyme B12-dependent glycerol dehydrogenase small subunit9e-76281
NC_008262:1139500:114752011475201147945426Clostridium perfringens SM101, complete genomeglycerol dehydrase, gamma subunit3e-75279
NC_010674:2185704:219872021987202199142423Clostridium botulinum B str. Eklund 17B, complete genomecoenzyme B12-dependent glycerol dehydratase, small subunit2e-56217
NC_010723:2082750:209358520935852094007423Clostridium botulinum E3 str. Alaska E43, complete genomecoenzyme B12-dependent glycerol dehydratase, small subunit4e-56216
NC_009648:3803622:384600838460083846433426Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomeglycerol dehydratase4e-46182
NC_013517:1055854:111811411181141118614501Sebaldella termitidis ATCC 33386, complete genomedehydratase small subunit5e-42169
NC_014633:442755:454556454556455038483Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequencedehydratase small subunit7e-42168
NC_014632:1404000:141353514135351413966432Ilyobacter polytropus DSM 2926 chromosome, complete genomeglycerol dehydratase, cobalamin-dependent subunit gamma2e-41167
NC_017243:1813158:182969218296921830171480Brachyspira intermedia PWS/A chromosome, complete genomeglycerol dehydrase8e-41165
NC_019970:2080419:209043520904352090938504Thermoanaerobacterium thermosaccharolyticum M0795, complete genomepropanediol dehydratase, small subunit7e-41165
NC_011837:830436:846147846147846695549Clostridium kluyveri NBRC 12016, complete genomehypothetical protein9e-40161
NC_009706:830461:846190846190846720531Clostridium kluyveri DSM 555 chromosome, complete genomeprotein DhaC1e-39161
NC_008497:1575884:157588415758841576411528Lactobacillus brevis ATCC 367, complete genomePropanediol dehydratase, small subunit7e-39159
NC_014654:1113116:112100611210061121524519Halanaerobium sp. 'sapolanicus' chromosome, complete genomedehydratase small subunit1e-38158
NC_013766:1202713:120911012091101209622513Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein8e-38155
NC_012488:1159463:116715711671571167669513Listeria monocytogenes Clip81459, complete genomediol dehydrase (diol dehydratase) gamma subunit (pddC)8e-38155
NC_010320:1949852:196045519604551960979525Thermoanaerobacter sp. X514 chromosome, complete genomedehydratase, small subunit9e-38155
NC_014538:985339:993365993365993889525Thermoanaerobacter sp. X513 chromosome, complete genomedehydratase small subunit9e-38155