Some Help

Query: NC_008261:1332864:1338644 Clostridium perfringens ATCC 13124, complete genome

Start: 1338644, End: 1340308, Length: 1665

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia

SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:1139500:1145256114525611469201665Clostridium perfringens SM101, complete genomeglycerol dehydratase, alpha subunit01139
NC_003366:1122654:1127780112778011294441665Clostridium perfringens str. 13, complete genomecoenzyme B12-dependent glycerol dehydrogenase large subunit01139
NC_010674:2185704:2199758219975822014221665Clostridium botulinum B str. Eklund 17B, complete genomeglycerol dehydratase large subunit01002
NC_010723:2082750:2094622209462220962861665Clostridium botulinum E3 str. Alaska E43, complete genomecoenzyme B12-dependent glycerol dehydratase, large subunit0998
NC_009648:3803622:3847033384703338487001668Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomeglycerol dehydratase0956
NC_014632:1404000:1414557141455714162211665Ilyobacter polytropus DSM 2926 chromosome, complete genomeglycerol dehydratase, cobalamin-dependent subunit alpha0916
NC_013517:1055854:1115745111574511174061662Sebaldella termitidis ATCC 33386, complete genomeGlycerol dehydratase0885
NC_017243:1813158:1830914183091418325751662Brachyspira intermedia PWS/A chromosome, complete genomeglycerol dehydratase0864
NC_019970:2080419:2091622209162220932891668Thermoanaerobacterium thermosaccharolyticum M0795, complete genomepropanediol dehydratase, large subunit0854
NC_013766:1202713:1206732120673212083961665Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein0845
NC_012488:1159463:1164779116477911664431665Listeria monocytogenes Clip81459, complete genomepropanediol dehydratase, alpha subunit0844
NC_010320:1949852:1961692196169219633561665Thermoanaerobacter sp. X514 chromosome, complete genomeglycerol dehydratase0840
NC_014538:985339:9909889909889926521665Thermoanaerobacter sp. X513 chromosome, complete genomeglycerol dehydratase0840
NC_014633:442755:4521894521894538531665Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceglycerol dehydratase0815
NC_011601:2139188:2185408218540821870091602Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomepropanediol dehydratase, large subunit, AdoCbl-dependent0804
NC_014654:1113116:1118629111862911202991671Halanaerobium sp. 'sapolanicus' chromosome, complete genomeGlycerol dehydratase0790
NC_008497:1575884:1577164157716415788401677Lactobacillus brevis ATCC 367, complete genomePropanediol dehydratase, large subunit0756
NC_011837:830436:8443988443988460621665Clostridium kluyveri NBRC 12016, complete genomehypothetical protein0733
NC_009706:830461:8444238444238460871665Clostridium kluyveri DSM 555 chromosome, complete genomeprotein DhaA0733