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Query: NC_008261:1332864:1333999 Clostridium perfringens ATCC 13124, complete genome

Start: 1333999, End: 1334829, Length: 831

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:1122654:112313611231361123966831Clostridium perfringens str. 13, complete genomehypothetical protein1e-156551
NC_008262:1139500:114061411406141141444831Clostridium perfringens SM101, complete genomemetallo-beta-lactamase family protein6e-155546
NC_016048:1390463:139131013913101392137828Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein1e-59229
NC_004557:2289135:229129722912972292160864Clostridium tetani E88, complete genomemetal dependent hydrolase3e-41169
NC_014033:1564733:156728015672801568071792Prevotella ruminicola 23 chromosome, complete genomemetallo-beta-lactamase family protein5e-34144
NC_014408:1340016:136902913690291369808780Methanothermobacter marburgensis str. Marburg chromosome, completehydrolase4e-32138
NC_003228:4449072:445472344547234455529807Bacteroides fragilis NCTC 9343, complete genomeputative hydrolase2e-29129
NC_006347:4562242:456789345678934568699807Bacteroides fragilis YCH46, complete genomeputative metallo-beta-lactamase2e-29129
NC_016776:4525065:453485245348524535658807Bacteroides fragilis 638R, complete genomeputative hydrolase2e-29129
NC_005126:1613818:164198816419881642788801Photorhabdus luminescens subsp. laumondii TTO1, complete genomehypothetical protein5e-27121
NC_012883:636560:648982648982649803822Thermococcus sibiricus MM 739, complete genomeHydrolase, metallo-beta-lactamase superfamily1e-22107
NC_012108:4907430:490964549096454910469825Desulfobacterium autotrophicum HRM2, complete genomeputative metal-dependent hydrolase6e-22104
NC_007498:1848437:185559818555981856434837Pelobacter carbinolicus DSM 2380, complete genomemetal-dependent hydrolase of the beta-lactamase superfamily II5e-2098.2
NC_018870:2316499:236990523699052370183279Thermacetogenium phaeum DSM 12270 chromosome, complete genomemetallo-beta-lactamase family protein6e-2098.2
NC_011978:1046279:106645210664521067219768Thermotoga neapolitana DSM 4359, complete genomeBeta-lactamase domain protein6e-2098.2
NC_013407:1205747:122246112224611223336876Methanocaldococcus vulcanius M7, complete genomebeta-lactamase domain protein1e-1997.1
NC_015499:197945:199839199839200696858Thermodesulfobium narugense DSM 14796 chromosome, complete genomebeta-lactamase domain protein9e-1994.4
NC_008942:1768588:179414717941471794962816Methanocorpusculum labreanum Z, complete genomehypothetical protein3e-1892.4
NC_008596:4104476:411917641191764120141966Mycobacterium smegmatis str. MC2 155, complete genomedihydropteroate synthase5e-1891.7
NC_009253:2577316:259888825988882599730843Desulfotomaculum reducens MI-1 chromosome, complete genomebeta-lactamase domain-containing protein1e-1790.5
UCMB5137:3660165:368937336893733690212840Bacillus atrophaeus UCMB-5137metal dependent hydrolase3e-1789.4
NC_011979:537862:558708558708559538831Geobacter sp. FRC-32, complete genomebeta-lactamase domain protein3e-1789.4
NC_014614:356746:371717371717372526810Clostridium sticklandii, complete genomeMetallo-beta-lactamase superfamily protein3e-1789.4
NC_015416:621513:622501622501623361861Methanosaeta concilii GP-6 chromosome, complete genomemetallo-beta-lactamase domain-containing protein5e-1788.2
NC_011894:7563668:7590592759059275916621071Methylobacterium nodulans ORS 2060, complete genomebeta-lactamase domain protein3e-1685.5
NC_009635:518000:536402536402537256855Methanococcus aeolicus Nankai-3 chromosome, complete genomebeta-lactamase domain-containing protein1e-1584
NC_016645:279232:300898300898301704807Pyrobaculum sp. 1860 chromosome, complete genomebeta-lactamase-like protein2e-1479.7
NC_020389:1083517:109070210907021091370669Methanosarcina mazei Tuc01, complete genome7,8 dihydropteroate synthase (methanopterin)1e-1170.5
NC_003901:1268995:127848712784871279155669Methanosarcina mazei Go1, complete genomemetal dependent hydrolase4e-1168.9
NC_014205:842314:881414881414882331918Staphylothermus hellenicus DSM 12710 chromosome, complete genomebeta-lactamase domain protein1e-0963.9
NC_014205:1257652:128060112806011281314714Staphylothermus hellenicus DSM 12710 chromosome, complete genomebeta-lactamase domain protein3e-0962.8
NC_016817:185000:204031204031204435405Pantoea ananatis LMG 5342 plasmid pPANA10, complete sequencebeta-lactamase domain-containing protein5e-0962