Pre_GI: BLASTP Hits

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Query: NC_008261:1048515:1065633 Clostridium perfringens ATCC 13124, complete genome

Start: 1065633, End: 1066187, Length: 555

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:1091766:110889611088961109450555Clostridium perfringens str. 13, complete genomepropanediol utilization protein5e-97352
NC_017179:2067015:208325620832562083807552Clostridium difficile BI1, complete genomeethanolamine/propanediol utilization protein5e-50196
NC_013315:2059007:207524820752482075799552Clostridium difficile CD196 chromosome, complete genomeethanolamine/propanediol utilization protein5e-50196
NC_015275:4493500:449541944954194495967549Clostridium lentocellum DSM 5427 chromosome, complete genomemicrocompartments protein8e-45179
NC_004557:2289135:229392922939292294486558Clostridium tetani E88, complete genomeputative ethanolamine utilization protein2e-37154
NC_011740:2072173:207462520746252075179555Escherichia fergusonii ATCC 35469, complete genomeputative Propanediol utilization: polyhedral bodies pduT2e-31135
NC_010723:1967106:197375319737531974301549Clostridium botulinum E3 str. Alaska E43, complete genomeethanolamine utilization protein EutM8e-29126
NC_014328:4316008:432566643256664326214549Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative microcompartment shellprotein4e-28124
NC_010674:1496500:151120515112051511753549Clostridium botulinum B str. Eklund 17B, complete genomemicrocompartments protein4e-28124
NC_010723:1465097:148141814814181481966549Clostridium botulinum E3 str. Alaska E43, complete genomemicrocompartments protein4e-28124
NC_009922:2556033:256755225675522568094543Alkaliphilus oremlandii OhILAs, complete genomemicrocompartments protein6e-26117
NC_010674:1822963:183537018353701835918549Clostridium botulinum B str. Eklund 17B, complete genomeethanolamine utilization protein EutM1e-25116
NC_009633:3933941:394396339439633944511549Alkaliphilus metalliredigens QYMF chromosome, complete genomemicrocompartments protein1e-25115
NC_016584:1998000:203312020331202033668549Desulfosporosinus orientis DSM 765 chromosome, complete genomecarbon dioxide concentrating mechanism/carboxysome shell protein1e-25115
NC_016584:1714507:172535917253591725907549Desulfosporosinus orientis DSM 765 chromosome, complete genomecarbon dioxide concentrating mechanism/carboxysome shell protein2e-25115
NC_016613:1877688:187768818776881878236549Vibrio sp. EJY3 chromosome 1, complete sequencepropanediol utilization protein PduT4e-25114
NC_007519:3240864:326083932608393261390552Desulfovibrio alaskensis G20 chromosome, complete genomeputative propanediol utilization protein PduT6e-25113
NC_009633:286677:304958304958305506549Alkaliphilus metalliredigens QYMF chromosome, complete genomemicrocompartments protein9e-25113
NC_018515:1663912:167934016793401679888549Desulfosporosinus meridiei DSM 13257 chromosome, complete genomecarbon dioxide concentrating mechanism/carboxysome shell protein2e-24112
NC_014614:284005:305288305288305818531Clostridium sticklandii, complete genomehypothetical protein8e-24109
NC_018870:705900:732503732503733051549Thermacetogenium phaeum DSM 12270 chromosome, complete genomemicrocompartment protein1e-23108
NC_016584:5625975:563443956344395634987549Desulfosporosinus orientis DSM 765 chromosome, complete genomecarbon dioxide concentrating mechanism/carboxysome shell protein1e-22106
NC_014654:1113116:113071811307181131266549Halanaerobium sp. 'sapolanicus' chromosome, complete genomemicrocompartments protein2e-22105
NC_017243:1813158:181874018187401819285546Brachyspira intermedia PWS/A chromosome, complete genomemicrocompartments protein2e-22105
NC_007907:456164:473525473525474052528Desulfitobacterium hafniense Y51, complete genomehypothetical protein5e-22103
NC_014654:2277461:229388322938832294437555Halanaerobium sp. 'sapolanicus' chromosome, complete genomemicrocompartments protein7e-2097.1
NC_009706:830461:854915854915855463549Clostridium kluyveri DSM 555 chromosome, complete genomemicrocompartment shellprotein6e-2097.1
NC_009706:830461:858991858991859539549Clostridium kluyveri DSM 555 chromosome, complete genomemicrocompartment shellprotein6e-2097.1
NC_011837:830436:854881854881855438558Clostridium kluyveri NBRC 12016, complete genomehypothetical protein5e-2097.1
NC_011837:830436:858856858856859413558Clostridium kluyveri NBRC 12016, complete genomehypothetical protein5e-2097.1
NC_009706:830461:852902852902853450549Clostridium kluyveri DSM 555 chromosome, complete genomemicrocompartment shellprotein1e-1996.3
NC_009706:830461:856877856877857425549Clostridium kluyveri DSM 555 chromosome, complete genomemicrocompartment shellprotein1e-1996.3
NC_011837:830436:852877852877853425549Clostridium kluyveri NBRC 12016, complete genomehypothetical protein1e-1996.3
NC_011837:830436:856852856852857400549Clostridium kluyveri NBRC 12016, complete genomehypothetical protein1e-1996.3
NC_014633:442755:447872447872448417546Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequencemicrocompartments protein9e-2096.3
NC_009253:1381401:139393013939301394475546Desulfotomaculum reducens MI-1 chromosome, complete genomemicrocompartments protein1e-1995.9
NC_010001:1488000:150087715008771501425549Clostridium phytofermentans ISDg, complete genomemicrocompartments protein9e-1786.3
NC_014538:985339:100455110045511005099549Thermoanaerobacter sp. X513 chromosome, complete genomemicrocompartments protein3e-1478.2
NC_007519:3240864:326498132649813265529549Desulfovibrio alaskensis G20 chromosome, complete genomepropanediol utilization protein (PduT)-like8e-1476.6
NC_014633:442755:462347462347462907561Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceethanolamine utilization protein6e-0753.5