Pre_GI: BLASTP Hits

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Query: NC_008261:1048515:1065359 Clostridium perfringens ATCC 13124, complete genome

Start: 1065359, End: 1065631, Length: 273

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:1091766:110862211086221108894273Clostridium perfringens str. 13, complete genomeethanolamine utilization protein4e-35146
NC_015275:4493500:449596044959604496235276Clostridium lentocellum DSM 5427 chromosome, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml6e-22102
NC_017179:2067015:208299120829912083263273Clostridium difficile BI1, complete genomeethanolamine/propanediol utilization protein2e-2097.8
NC_013315:2059007:207498320749832075255273Clostridium difficile CD196 chromosome, complete genomeethanolamine/propanediol utilization protein2e-2097.8
NC_007519:3240864:326553132655313265806276Desulfovibrio alaskensis G20 chromosome, complete genomeethanolamine utilization protein eutN2e-1373.9
NC_014376:1586649:160310816031081603380273Clostridium saccharolyticum WM1 chromosome, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml5e-1373.2
NC_018870:705900:730835730835731137303Thermacetogenium phaeum DSM 12270 chromosome, complete genomeputative ethanolamine utilization protein EutN/carboxysome structural protein Ccml2e-1270.9
NC_009922:868262:881703881703881975273Alkaliphilus oremlandii OhILAs, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml3e-1270.5
NC_009633:286677:303319303319303603285Alkaliphilus metalliredigens QYMF chromosome, complete genomeethanolamine utilization protein EutN/carboxysome structural protein Ccml9e-1165.5
NC_018515:1663912:167768716776871677980294Desulfosporosinus meridiei DSM 13257 chromosome, complete genomecarbon dioxide concentrating mechanism/carboxysome shell protein3e-1063.9
NC_014538:985339:999072999072999374303Thermoanaerobacter sp. X513 chromosome, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml4e-1063.5
NC_010320:1949852:195497019549701955272303Thermoanaerobacter sp. X514 chromosome, complete genomeethanolamine utilization protein EutN/carboxysome structural protein Ccml4e-1063.5
NC_009922:2556033:256944525694452569705261Alkaliphilus oremlandii OhILAs, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml4e-1063.5
NC_016584:1998000:203146720314672031760294Desulfosporosinus orientis DSM 765 chromosome, complete genomecarbon dioxide concentrating mechanism/carboxysome shell protein6e-1062.8
NC_017243:1813158:1819282181928218209431662Brachyspira intermedia PWS/A chromosome, complete genomehypothetical protein7e-1062.8
NC_013192:63111:776177761777886270Leptotrichia buccalis DSM 1135, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml8e-1062.4
NC_013517:1055854:112942011294201129668249Sebaldella termitidis ATCC 33386, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml2e-0961.2
NC_016584:1714507:172370617237061723999294Desulfosporosinus orientis DSM 765 chromosome, complete genomecarbon dioxide concentrating mechanism/carboxysome shell protein2e-0961.2
NC_019970:2080419:208539220853922085724333Thermoanaerobacterium thermosaccharolyticum M0795, complete genomecarbon dioxide concentrating mechanism/carboxysome shell protein3e-0960.8
NC_007907:456164:475400475400475690291Desulfitobacterium hafniense Y51, complete genomehypothetical protein8e-0958.9
NC_009633:3933941:394585739458573946120264Alkaliphilus metalliredigens QYMF chromosome, complete genomeethanolamine utilization protein EutN/carboxysome structural protein Ccml1e-0858.9
NC_014614:284005:303652303652303912261Clostridium sticklandii, complete genomeputative carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein1e-0858.9
NC_009922:411434:422262422262422552291Alkaliphilus oremlandii OhILAs, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml1e-0858.5
NC_009253:1381401:139228513922851392575291Desulfotomaculum reducens MI-1 chromosome, complete genomeethanolamine utilization protein EutN/carboxysome structural protein Ccml2e-0858.2
NC_014328:773095:790102790102790377276Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative microcompartment shellprotein3e-0857
NC_010001:1488000:149920014992001499460261Clostridium phytofermentans ISDg, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml3e-0857.4
NC_010674:1496500:150959415095941509857264Clostridium botulinum B str. Eklund 17B, complete genomeethanolamine utilization protein EutN/carboxysome structural protein Ccml5e-0856.6
NC_012563:2384500:239472323947232394986264Clostridium botulinum A2 str. Kyoto, complete genomeputative polyhedral organelle formation protein1e-0755.1
NC_009495:2244774:225131922513192251582264Clostridium botulinum A str. ATCC 3502 chromosome, complete genomepolyhedral organelle formation protein1e-0755.1
NC_009697:2173000:217996121799612180224264Clostridium botulinum A str. ATCC 19397 chromosome, completepolyhedral organelle formation protein1e-0755.1
NC_009698:2171151:218018021801802180443264Clostridium botulinum A str. Hall chromosome, complete genomepolyhedral organelle formation protein1e-0755.1
NC_012658:2295536:230868923086892308952264Clostridium botulinum Ba4 str. 657 chromosome, complete genomeethanolamine utilization protein EutN/carboxysome structural protein Ccml1e-0755.1
NC_014501:3210323:322010032201003220408309Cyanothece sp. PCC 7822 chromosome, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml1e-0755.1
NC_011729:1496848:150827015082701508581312Cyanothece sp. PCC 7424 chromosome, complete genomeethanolamine utilization protein EutN/carboxysome structural protein Ccml2e-0754.3
NC_014019:3543389:355060035506003550884285Bacillus megaterium QM B1551 chromosome, complete genomeethanolamine utilization protein EutN2e-0754.3
NC_014654:1113116:112663811266381126913276Halanaerobium sp. 'sapolanicus' chromosome, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml2e-0754.3
NC_009706:830461:850985850985851266282Clostridium kluyveri DSM 555 chromosome, complete genomemicrocompartment shellprotein3e-0753.5
NC_011837:830436:850960850960851241282Clostridium kluyveri NBRC 12016, complete genomehypothetical protein3e-0753.5
NC_016048:1694631:169616316961631696426264Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein3e-0753.9
NC_010001:1745089:176275617627561763019264Clostridium phytofermentans ISDg, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml3e-0753.9
NC_009699:2287893:230053223005322300795264Clostridium botulinum F str. Langeland chromosome, complete genomepolyhedral organelle formation protein3e-0754.3
NC_017297:2288000:230064423006442300907264Clostridium botulinum F str. 230613 chromosome, complete genomeputative polyhedral organelle formation protein3e-0754.3
NC_010674:1822963:183221818322181832490273Clostridium botulinum B str. Eklund 17B, complete genomeethanolamine utilization protein EutN5e-0753.1
NC_014633:442755:459532459532459798267Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceethanolamine utilization protein EutN/carboxysome structural protein Ccml5e-0753.1
NC_016584:5625975:563633856363385636598261Desulfosporosinus orientis DSM 765 chromosome, complete genomecarbon dioxide concentrating mechanism/carboxysome shell protein5e-0753.1
NC_014328:1286407:129389312938931294159267Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeethanolamine utilization protein EutN6e-0753.1
NC_014328:4316008:432756243275624327828267Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeethanolamine utilization protein EutN6e-0753.1
NC_016613:1877688:188140718814071881670264Vibrio sp. EJY3 chromosome 1, complete sequenceputative Ethanolamine utilization protein (eutN-like)8e-0752.4
NC_012491:5914500:593643059364305936717288Brevibacillus brevis NBRC 100599, complete genomehypothetical protein1e-0651.6
NC_010723:1967106:197718119771811977453273Clostridium botulinum E3 str. Alaska E43, complete genomeethanolamine utilization protein EutN2e-0651.2