Pre_GI: BLASTP Hits

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Query: NC_008261:1048515:1048515 Clostridium perfringens ATCC 13124, complete genome

Start: 1048515, End: 1049165, Length: 651

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003366:1091766:109176610917661092416651Clostridium perfringens str. 13, complete genomehypothetical protein6e-110396
NC_016751:1776669:179875217987521799375624Marinitoga piezophila KA3 chromosome, complete genomeADP-ribose pyrophosphatase7e-37153
NC_009495:1516000:153221415322141532837624Clostridium botulinum A str. ATCC 3502 chromosome, complete genomepyrophosphatase, MutT/nudix family2e-31135
NC_010520:1586000:160518416051841605807624Clostridium botulinum A3 str. Loch Maree, complete genomepyrophosphatase, MutT/nudix family3e-31134
NC_010003:570643:585398585398586006609Petrotoga mobilis SJ95, complete genomeNUDIX hydrolase5e-30130
NC_013171:1364464:138465813846581385248591Anaerococcus prevotii DSM 20548, complete genomeNUDIX hydrolase3e-21101
NC_009718:643200:656567656567657112546Fervidobacterium nodosum Rt17-B1, complete genomeNUDIX hydrolase9e-21100
NC_014221:2188250:218978321897832190424642Truepera radiovictrix DSM 17093 chromosome, complete genomeNUDIX hydrolase7e-1890.5
NC_021182:93000:137136137136137798663Clostridium pasteurianum BC1, complete genomeNTP pyrophosphohydrolase6e-1477.4
NC_014761:516981:529877529877530365489Oceanithermus profundus DSM 14977 chromosome, complete genomenudix hydrolase7e-1477.4
NC_014632:1514500:152867415286741529351678Ilyobacter polytropus DSM 2926 chromosome, complete genomeNUDIX hydrolase2e-1065.5
NC_012668:2258854:226042722604272261041615Vibrio cholerae MJ-1236 chromosome 1, complete sequencehypothetical protein4e-1064.7
NC_013854:1686997:170721517072151707910696Azospirillum sp. B510, complete genomeuncharacterized Nudix hydrolase2e-0858.9
NC_008702:2378890:238283923828392383312474Azoarcus sp. BH72, complete genomeconserved hypothetical protein5e-0857.8