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Query: NC_008258:2473000 Shigella flexneri 5 str. 8401, complete genome

Start: 2473000, End: 2497698, Length: 24699

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_003198:2453074*2453074247785124778Salmonella enterica subsp. enterica serovar Typhi str. CT18,0852BLASTN svgBLASTP svg
NC_010473:2548946*2548946258173732792Escherichia coli str. K-12 substr. DH10B, complete genome024210BLASTN svgBLASTP svg
NC_002695:3189425*3189425321610426680Escherichia coli O157:H7 str. Sakai, complete genome020980BLASTN svgBLASTP svg
NC_010498:25557062555706258100625301Escherichia coli SMS-3-5, complete genome019410BLASTN svgBLASTP svg
NC_011750:2585015*2585015261198826974Escherichia coli IAI39 chromosome, complete genome019320BLASTN svgBLASTP svg
NC_004431:27472372747237277257425338Escherichia coli CFT073, complete genome018790BLASTN svgBLASTP svg
NC_002655:3260500*3260500328246521966Escherichia coli O157:H7 EDL933, complete genome014900BLASTN svgBLASTP svg
NC_007946:26254612625461264923523775Escherichia coli UTI89, complete genome014780BLASTN svgBLASTP svg
NC_007606:23530982353098237552222425Shigella dysenteriae Sd197, complete genome014200BLASTN svgBLASTP svg
CP002797:24729082472908249359920692Escherichia coli NA114, complete genome09969BLASTN svgBLASTP svg
NC_000913:2455037*2455037248136126325Escherichia coli K12, complete genome07975BLASTN svgBLASTP svg
AC_000091:24624612462461248878526325Escherichia coli W3110 DNA, complete genome07975BLASTN svgBLASTP svg
NC_007606:4182188*4182188420162219435Shigella dysenteriae Sd197, complete genome07567BLASTN svgBLASTP svg
NC_011750:43900004390000444275952760Escherichia coli IAI39 chromosome, complete genome02694BLASTN svgBLASTP svg
NC_014121:37769023776902380024423343Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, complete0954BLASTN svgBLASTP svg
NC_008563:26104992610499263209921601Escherichia coli APEC O1, complete genome025560BLASTN svgBLASTP svg
NC_010658:2529033*2529033255581226780Shigella boydii CDC 3083-94, complete genome026790BLASTN svgBLASTP svg
NC_004741:24562972456297247959923303Shigella flexneri 2a str. 2457T, complete genome034700BLASTN svgBLASTP svg
NC_004337:24784612478461250482826368Shigella flexneri 2a str. 301, complete genome034570BLASTN svgBLASTP svg
CU928160:25130002513000253520022201Escherichia coli IAI1 chromosome, complete genome033570BLASTN svgBLASTP svg
NC_007384:25878762587876261159923724Shigella sonnei Ss046, complete genome033360BLASTN svgBLASTP svg
CP002185:26596282659628268309923472Escherichia coli W, complete genome033350BLASTN svgBLASTP svg
AP010958:2911741*2911741294759935859Escherichia coli O103:H2 str. 12009 DNA, complete genome033320BLASTN svgBLASTP svg
NC_009801:26397872639787266007120285Escherichia coli E24377A, complete genome033320BLASTN svgBLASTP svg
NC_011748:27085002708500272609917600Escherichia coli 55989, complete genome032930BLASTN svgBLASTP svg
CU928145:27085002708500272609917600Escherichia coli 55989 chromosome, complete genome032930BLASTN svgBLASTP svg
NC_011751:27688642768864278709918236Escherichia coli UMN026 chromosome, complete genome031050BLASTN svgBLASTP svg
NC_008253:24997352499735251999320259Escherichia coli 536, complete genome030190BLASTN svgBLASTP svg
NC_009800:2505872*2505872252809922228Escherichia coli HS, complete genome027940BLASTN svgBLASTP svg
NC_010468:14127911412791143188119091Escherichia coli ATCC 8739, complete genome027620BLASTN svgBLASTP svg
CP002516:14194131419413144219622784Escherichia coli KO11, complete genome027580BLASTN svgBLASTP svg
NC_007613:2376974*2376974240022423251Shigella boydii Sb227, complete genome026930BLASTN svgBLASTP svg
NC_012917:32411963241196329451553320Pectobacterium carotovorum subsp. carotovorum PC1, complete genome7e-149535BLASTN svgBLASTP svg
NC_003198:38241873824187384903924853Salmonella enterica subsp. enterica serovar Typhi str. CT18,2e-121444BLASTN svgBLASTP svg
NC_004631:38096783809678383452924852Salmonella enterica subsp. enterica serovar Typhi Ty2, complete2e-121444BLASTN svgBLASTP svg
NC_006905:39427533942753396819425442Salmonella enterica subsp. enterica serovar Choleraesuis str2e-118434BLASTN svgBLASTP svg
NC_015968:33019583301958333436632409Enterobacter asburiae LF7a chromosome, complete genome1e-45192BLASTN svgBLASTP svg
NC_013850:33035003303500332954126042Klebsiella variicola At-22 chromosome, complete genome5e-20107BLASTN svgBLASTP svg
NC_004547:843475*84347586442120947Erwinia carotovora subsp. atroseptica SCRI1043, complete genome3e-18101BLASTN svgBLASTP svg
NC_009648:38036223803622385072747106Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genome5e-0867.9BLASTN svgBLASTP svg
NC_015065:16231716231720800945693Acidobacterium sp. MP5ACTX9 plasmid pACIX902, complete sequence2e-0765.9BLASTN svgBLASTP svg
NC_012779:3176820*3176820323178054961Edwardsiella ictaluri 93-146, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_002506:82240182240184494222542Vibrio cholerae O1 biovar eltor str. N16961 chromosome II, complete3e-0661.9BLASTN svgBLASTP svg