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Query: NC_008258:3224721:3234852 Shigella flexneri 5 str. 8401, complete genome

Start: 3234852, End: 3235568, Length: 717

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004741:3240909:3251041325104132520781038Shigella flexneri 2a str. 2457T, complete genome2e-129461
NC_012759:3143455:3153585315358531547721188Escherichia coli BW2952 chromosome, complete genomehypothetical protein3e-126451
NC_000913:3256307:3266437326643732676241188Escherichia coli K12, complete genomehypothetical protein3e-126451
AC_000091:3258377:3268270326827032694571188Escherichia coli W3110 DNA, complete genomehypothetical protein3e-126451
NC_010473:3354052:3364182336418233653691188Escherichia coli str. K-12 substr. DH10B, complete genomehypothetical protein3e-126451
NC_012947:630757:6379876379876390901104Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completehypothetical protein1e-125449
NC_012967:3191319:3201449320144932025521104Escherichia coli B str. REL606 chromosome, complete genomehypothetical protein1e-125449
NC_009800:3307123:3317253331725333183561104Escherichia coli HS, complete genome7e-126449
NC_002695:3994970:4008044400804440092311188Escherichia coli O157:H7 str. Sakai, complete genomehypothetical protein1e-125448
NC_011415:3523364:3536438353643835376251188Escherichia coli SE11 chromosome, complete genomehypothetical protein3e-124444
NC_013941:3884725:3897799389779938989861188Escherichia coli O55:H7 str. CB9615 chromosome, complete genomehypothetical protein6e-124443
NC_010468:613812:6210426210426221451104Escherichia coli ATCC 8739, complete genome4e-124443
CU928160:3344746:3354876335487633560631188Escherichia coli IAI1 chromosome, complete genomeconserved hypothetical protein4e-124443
NC_011741:3344746:3354876335487633560631188Escherichia coli IAI1 chromosome, complete genomehypothetical protein4e-124443
NC_010498:3488513:3498643349864334998301188Escherichia coli SMS-3-5, complete genomehypothetical protein8e-122436
NC_011751:3710786:3723861372386137250481188Escherichia coli UMN026 chromosome, complete genomehypothetical protein1e-120432
NC_011750:3768692:3781766378176637829531188Escherichia coli IAI39 chromosome, complete genomehypothetical protein7e-120429
NC_009801:3595001:3603292360329236044791188Escherichia coli E24377A, complete genomehypothetical protein8e-120429
CP002185:3475991:3486119348611934873061188Escherichia coli W, complete genomehypothetical protein1e-119428
CP002516:613462:6187676187676199541188Escherichia coli KO11, complete genomehypothetical protein1e-119428
NC_016902:613462:6187676187676199541188Escherichia coli KO11FL chromosome, complete genomehypothetical protein1e-119428
NC_011748:3608917:3621991362199136231781188Escherichia coli 55989, complete genomehypothetical protein2e-118425
CU928145:3608917:3621991362199136231781188Escherichia coli 55989 chromosome, complete genomeconserved hypothetical protein2e-118425
NC_010658:3014371:301754130175413018326786Shigella boydii CDC 3083-94, complete genome2e-99362
NC_007613:2981829:299169329916932992484792Shigella boydii Sb227, complete genomehypothetical protein6e-45180